Effects of <i>T'ai Chi</i> on Chronic Systemic Inflammation

You, Tongjian; Ogawa, Elisa

doi:10.1089/acm.2019.0136

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Several studies indicate that increased levels of oxidative stress and inflammatory biomarkers are common among persons with depression [ 69 , 70 ]. Our findings are consistent with a prior systematic review examining the effect of Tai Chi on inflammatory markers [ 71 ], with mixed results found after the intervention. In this study, we observed increases in IL-6 (ES = 0.59) and IL-10 (ES = 0.61) though these did not reach statistical significance due to the sample size, while no significant changes in TNF- α or BDNF were found (all p values >0.05).…”

Section: Discussionsupporting

confidence: 92%

The Feasibility of Tai Chi Exercise as a Beneficial Mind-Body Intervention in a Group of Community-Dwelling Stroke Survivors with Symptoms of Depression

Taylor-Piliae

Morrison

Hsu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Depression is prevalent among one-third to two-thirds of acute and chronic stroke survivors. Despite the availability of pharmacotherapies and/or psychotherapies, depression persists, even for 5–10 years after stroke, reflecting limited treatment responses and/or adherence to this conventional care. Mind-body interventions are commonly used among adults to ameliorate depressive symptoms. Thus, the feasibility of Tai Chi, alongside conventional care, to manage poststroke depression was investigated using a single-group pre-post intervention design. Recruitment and retention, intervention adherence, safety, acceptability, and fidelity were assessed. Symptoms of depression, anxiety, and stress were assessed using standardized questionnaires, objective sleep was assessed via a research-grade triaxial accelerometer, and blood samples were taken to measure oxidative stress, inflammatory markers, and a neurotrophic growth factor using commercially available kits per manufacturer’s protocol. Pre-post intervention changes were assessed using paired t-tests. We enrolled stroke survivors (N = 11, mean age = 69.7 ± 9.3) reporting depression symptoms. After the intervention, we observed significant reductions in symptoms of depression (−5.3 ± 5.9, p = 0.01 ), anxiety (−2.2 ± 2.4, p = 0.01 ), and stress (−4.6 ± 4.8, p = 0.01 ), along with better sleep efficiency (+1.8 ± 1.8, p = 0.01 ), less wakefulness after sleep onset (−9.3 ± 11.6, p = 0.04 ), and less time awake (−9.3 ± 11.6, p = 0.04 ). There was a 36% decrease in oxidative stress ( p = 0.02 ), though no significant changes in the other biomarkers were found (all p values >0.05). Tai Chi exercise is a feasible intervention that can be used alongside conventional care to manage poststroke depression, aid in reducing symptoms of anxiety and stress, and improve sleep.

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Section: Discussionsupporting

confidence: 92%

The Feasibility of Tai Chi Exercise as a Beneficial Mind-Body Intervention in a Group of Community-Dwelling Stroke Survivors with Symptoms of Depression

Taylor-Piliae

Morrison

Hsu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Our findings are comparable with similar studies that assessed the effect of mind-body therapies using mixed interventions including meditation, Yoga and TQ [33,66]. Prior reviews that examined the effect of TQ on immunity and inflammation have reported no strong evidence of a favorable effect of TQ on inflammation [67] and the immune system [68] and insufficient evidence to support the clinical application of TQ to reduce infection [68,69]. These earlier reviews included fewer RCTs, and non-RCT studies, and a less comprehensive literature search which limits the conclusions made.…”

Section: Discussionsupporting

confidence: 85%

The Effects of Tai Chi and Qigong on Immune Responses: A Systematic Review and Meta-Analysis

Bae

Lamoury

et al. 2020

Medicines

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Background: Effective preventative health interventions are essential to maintain well-being among healthcare professionals and the public, especially during times of health crises. Several studies have suggested that Tai Chi and Qigong (TQ) have positive impacts on the immune system and its response to inflammation. The aim of this review is to evaluate the current evidence of the effects of TQ on these parameters. Methods: Electronic searches were conducted on databases (Medline, PubMed, Embase and ScienceDirect). Searches were performed using the following keywords: “Tai Chi or Qigong” and “immune system, immune function, immunity, Immun*, inflammation and cytokines”. Studies published as full-text randomized controlled trials (RCTs) in English were included. Estimates of change in the levels of immune cells and inflammatory biomarkers were pooled using a random-effects meta-analysis where randomised comparisons were available for TQ versus active controls and TQ versus non-active controls. Results: Nineteen RCTs were selected for review with a total of 1686 participants and a range of 32 to 252 participants within the studies. Overall, a random-effects meta-analysis found that, compared with control conditions, TQ has a significant small effect of increasing the levels of immune cells (SMD, 0.28; 95% CI, 0.13 to 0.43, p = 0.00), I2 = 45%, but not a significant effect on reducing the levels of inflammation (SMD, −0.15; 95% CI, −0.39 to 0.09, p = 0.21), I2 = 85%, as measured by the systemic inflammation biomarker C-reactive protein (CRP) and cell mediated biomarker cytokines. This difference in results is due to the bidirectional regulation of cytokines. An overall risk of bias assessment found three RCTs with a low risk of bias, six RCTs with some concerns of bias, and ten RCTs with a high risk of bias. Conclusions: Current evidence indicates that practising TQ has a physiologic impact on immune system functioning and inflammatory responses. Rigorous studies are needed to guide clinical guidelines and harness the power of TQ to promote health and wellbeing.

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“…In addition, there is some evidence that tai chi alters DNA methylation to slow age‐related methylation losses or gains, suggesting it may impart beneficial epigenetic changes (Ren et al, 2012). Further studies have shown that tai chi impacts inflammatory markers involved in aging (Muñoz‐Vergara et al, 2023; You & Ogawa, 2019; You et al, 2020). In a three‐arm RCT of cognitive behavioral therapy vs. tai chi chih vs. sleep seminar, those in the tai chi arm had statistically significant reductions in proinflammatory cytokines and proinflammatory gene expression, as well as reduced activity of proinflammatory transcription factors (NF‐kB and activator protein 1) (Irwin et al, 2015).…”

Section: Mind–body Therapies Are Promising Approaches To Frailty Prev...mentioning

confidence: 99%

Holistic frailty prevention: The promise of movement‐based mind–body therapies

Loewenthal,

Berning,

Wayne

et al. 2023

Aging Cell

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Aging is characterized by fundamental cellular and molecular hallmarks that result in physiologic decline of most body systems. This may culminate in frailty, a state of decreased reserve. Because frailty is a state of multisystem dysregulation, multimodal interventions may be necessary to mitigate and prevent progression rather than interventions targeting a single system. Movement‐based mind–body therapies, such as tai chi and yoga, are promising multimodal strategies for frailty prevention and treatment given their inherent multicomponent nature. In this review, we summarize the links between hallmarks of aging and frailty and how tai chi and yoga may impact these hallmarks. We review trial evidence for the impact of tai chi and yoga on frailty in older populations and discuss opportunities for future research.

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Effects of T'ai Chi on Chronic Systemic Inflammation

Cited by 6 publications

References 13 publications

The Feasibility of Tai Chi Exercise as a Beneficial Mind-Body Intervention in a Group of Community-Dwelling Stroke Survivors with Symptoms of Depression

The Feasibility of Tai Chi Exercise as a Beneficial Mind-Body Intervention in a Group of Community-Dwelling Stroke Survivors with Symptoms of Depression

The Effects of Tai Chi and Qigong on Immune Responses: A Systematic Review and Meta-Analysis

Holistic frailty prevention: The promise of movement‐based mind–body therapies

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