Effects of
            <i>Trigonella foenum graecum</i>
            (fenugreek) on rheumatoid arthritis: a systematic review

Faghfoori, Zeinab; Javadivala, Zeinab; Khalili, Yeganeh; Mahdavi, Aida Malek

doi:10.1080/08923973.2023.2202298

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…It is used as a mouthwash for oral hygiene, gum health, throat irritation, gingivitis, and dental infections. Various bioactive compounds such alkaloids, tannins, flavonoids, steroids, and triterpenoids have shown therapeutic properties in many research investigations [3,8,9]. To support the significance of present work, the bibliographic analysis has also been done.…”

Section: Introductionmentioning

confidence: 70%

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Steroids and Triterpenoids in Acacia Catechu Bark Extracts: A Comparative Study and Bibliographic Analysis

TIWARI,

TIWARI

2024

Int J Curr Pharm Sci

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Objective: Plant-derived steroids and triterpenes have been recognized for a number of health benefits. As indicated in previous research, some of the phytosterols are essential dietary substances. This study was aimed at investigating the presence or absence of these phytochemicals in various test bark extracts from Acacia catechu plant samples. Methods: For this study, thirty samples of test plants were gathered in various seasons from the research location. Six different solvents were then prepared for each sample. Then the qualitative tests of the studied parameters were done using various standardized methods. Additionally, bibliographic analysis was done to validate and co-relate the present study with earlier findings. Results: Results showed the presence of test parameters in all solvent systems except aqueous extracts, though the colour intensity (quantity) was different in all other extracts. Based on the dark-colored reaction mixture, it can be claimed that the steroid and triterpene content was relatively higher in methanolic and ethanolic extracts. The comparative bibliographic study was also validating the beneficial applications of the same. Conclusion: Possibly, this preliminary study helped to find out the medicinal significance of native flora of Guna district and also serve as the base for further investigations.

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Section: Introductionmentioning

confidence: 70%

“…Certain triterpenoids possess hemolytic and cytostatic characteristics that might lead to adverse effects, limiting their therapeutic potential. Semisynthetic derivatives of triterpenoids are being used to remedy the issue [8,9].…”

Section: Introductionmentioning

confidence: 99%

Steroids and Triterpenoids in Acacia Catechu Bark Extracts: A Comparative Study and Bibliographic Analysis

TIWARI,

TIWARI

2024

Int J Curr Pharm Sci

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“…Currently, people are paying more attention to the new medicinal potential of fenugreek. Some studies have shown that fenugreek surgery has favorable effects on rheumatoid arthritis [ 8 ]. The ethanolic extract of fenugreek has an inhibitory effect on the deleterious phenomenon of glycation, and it can be a nutraceutical against aging and associated morbidities [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic and Transcriptomic Analyses Reveal the Molecular Mechanism Underlying the Massive Accumulation of Secondary Metabolites in Fenugreek (Trigonella foenum-graecum L.) Seeds

Zhao,

Wu,

Yang

et al. 2024

Genes

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Fenugreek (Trigonella foenum-graecum L.) is a traditional medicinal plant for treating human diseases that is widely cultivated in many countries. However, the component and related metabolic pathways are still unclear. To understand the changes in expression of the component and related genes during seed development, this study employed metabolomic and transcriptomic analyses and integrative analysis to explore the metabolites and pathways involved in the growth of fenugreek. The antifungal activity of the fenugreek seeds was also analyzed. A total of 9499 metabolites were identified in the positive ion mode, and 8043 metabolites were identified in the negative ion mode. Among them, the main components were fatty acyls, prenol lipids, steroids, steroid derivatives, flavonoids, and isoflavonoids. Among these enriched pathways, the top 20 pathways were “flavone and flavonol biosynthesis”, “isoflavonoid biosynthesis”, and “flavonoid biosynthesis”. 3,7-Di-O-methylquercetin, flavonoids, pseudobaptigenin, isoflavonoids, methylecgonine, alkaloids, and derivatives were the most significantly upregulated metabolites. There were 38,137 differentially expressed genes (DEGs) identified via transcriptomic analysis. According to the KEGG pathway enrichment analysis, 147 DEGs were significantly enriched in “flavonoid biosynthesis”. Ten DEGs of the six key enzymes were found to be involved in three pathways related to flavonoid and alkaloid synthesis in fenugreek. The antifungal activity test revealed the inhibitory effect of the ethanol extract of fenugreek seeds on Alternaria tenuissima (Kunze)Wiltshire and Magnaporthe oryzae. These findings further prove that the use of botanical pesticides in fenugreek fruit has research value.

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Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

Alu'datt,

Rababah,

Al‐ali

et al. 2024

Journal of Food Science

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Despite long‐standing uses in several food and medicine traditions, the full potential of the leguminous crop fenugreek (Trigonella foenum‐graecum L.) remains to be realized in the modern diet. Not only its seeds, which are highly prized for their culinary and medicinal properties, but also its leaves and stems abound in phytochemicals with high nutritional and health promoting attributes. Fenugreek dual food‐medicine applications and reported metabolic activities include hypoglycemic, antihyperlipidemic, antioxidative, anti‐inflammatory, antiatherogenic, antihypertensive, anticarcinogenic, immunomodulatory, and antinociceptive effects, with potential organ‐protective effects at the cardiovascular, digestive, hepatic, endocrine, and central nervous system levels. Effectiveness in alleviating certain inflammatory skin conditions and dysfunctions of the reproductive system was also suggested. As a food ingredient, fenugreek can enhance the sensory, nutritional, and nutraceutical qualities of a wide variety of foods. Its high nutritive density can assist with the design of dietary items that meet the demand for novelty, variety, and healthier foods. Its seeds provide essential protective nutrients and other bioactive compounds, notably galactomannans, flavonoids, coumarins, saponins, alkaloids, and essential oils, whose health benefits, alone or in conjunction with other bioactives, are only beginning to be tapped into in the food industries. This review summarizes the current state of evidence on fenugreek potential for functional food development, focusing on the nutrients and non‐nutrient bioactive components of interest from a dietary perspective, and their applications for enhancing the functional and nutraceutical value of foods and beverages. New developments, safety, clinical evidence, presumed mechanisms of action, and future perspectives are discussed.Highlights Fenugreek seeds and leaves have long‐standing uses in the food‐medicine continuum. Fenugreek phytochemicals exert broad‐spectrum biological and pharmacological activities. They show high preventive and nutraceutical potential against common chronic diseases. Current evidence supports multiple mechanisms of action mediated by distinct bioactives. Opportunities for fenugreek‐based functional foods and nutraceuticals are expanding.

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Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review

Cited by 4 publications

References 26 publications

Steroids and Triterpenoids in Acacia Catechu Bark Extracts: A Comparative Study and Bibliographic Analysis

Steroids and Triterpenoids in Acacia Catechu Bark Extracts: A Comparative Study and Bibliographic Analysis

Metabolomic and Transcriptomic Analyses Reveal the Molecular Mechanism Underlying the Massive Accumulation of Secondary Metabolites in Fenugreek (Trigonella foenum-graecum L.) Seeds

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

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