Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats

Kesner, Raymond P.; Jackson-Smith, Pamela; Henry, Clarissa A.; Amann, Kelly

doi:10.1016/0091-3057(94)00367-r

Cited by 24 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that ibogaine causes acute motor impairment in animals, even in low dosages. No studies published results on whether these effects last over time, although three of the five studies described that tremors and ataxia disappeared within 24 h. 44 , 45 , 46 This would be consistent with human studies, where these effects also disappeared within 24 h. 47 It is hypothesised that these effects on motor functioning are caused by ibogaines’ exciting effect on neurons in the inferior olivary nucleus, within the medulla oblongata. Sustained release of glutamate in neurons of the olivary nucleus triggered by ibogaine may contribute to excitotoxic degeneration of cells within the cerebellum.…”

Section: Discussionmentioning

confidence: 70%

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

et al. 2016

View full text Add to dashboard Cite

Ibogaine is a naturally occurring substance which has been increasingly used in the lay-scene to reduce craving and relapse in patients with substance use disorders (SUDs). Although human clinical trials on the safety and efficacy of ibogaine are lacking, animal studies do support the efficacy of ibogaine. In this systematic review and meta-analysis (MA), we summarise these animal findings, addressing three questions: (1) does ibogaine reduce addictive behaviour in animal models of SUDs?; (2) what are the toxic effects of ibogaine on motor functioning, cerebellum and heart rhythm?; (3) what are neuropharmacological working mechanisms of ibogaine treatment in animal models of SUDs? MA of 27 studies showed that ibogaine reduced drug self-administration, particularly during the first 24 h after administration. Ibogaine had no effect on drug-induced conditioned place preference. Ibogaine administration resulted in motor impairment in the first 24 h after supplementation, and cerebral cell loss even weeks after administration. Data on ibogaines effect on cardiac rhythm, as well as on its neuropharmacological working mechanisms are limited. Our results warrant further studies into the clinical efficacy of ibogaine in SUD patients in reducing craving and substance use, but close monitoring of the patients is recommended because of the possible toxic effects. In addition, more work is needed to unravel the neuropharmacological working mechanisms of ibogaine and to investigate its effects on heart rhythm.

show abstract

Section: Discussionmentioning

confidence: 70%

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1996). Rhythmic electrical stimulation of the inferior olive under experimental conditions prevents gain modification of the horizontal vestibulocular reflex in cats (Luebke & Robinson 1994), and ibogaine, another drug that produces tremor likely via rhythmic activation of the inferior olive (DeMontigny & Lamarre 1974), blocks spatial learning in rats (Kesner et al . 1995).…”

Section: Introductionmentioning

confidence: 99%

Acute inactivation of the inferior olive blocks associative learning

Welsh

Harvey

1998

Eur J of Neuroscience

View full text Add to dashboard Cite

Can acute inactivation of the inferior olive block associative learning? We anaesthetized the inferior olive with lidocaine while rabbits simultaneously: (i) performed conditioned nictitating membrane responses to a flashing light to which they had already been trained; and (ii) underwent their first experience with classical conditioning of the same response to a tone. Inactivation of the inferior olive immediately and reversibly abolished the performance of conditioned responses and prevented learning during rabbits' initial conditioning with a tone-conditioned stimulus. When olivary function was restored, rabbits showed no signs of having learned under olivary anaesthesia. The experiment demonstrates that an acute disruption in olivary function can block learning, in addition to severely degrading motor control. The results are interpreted to indicate the importance of the inferior olive in optimizing learning, perhaps through a general role in regulating temporal processing.

show abstract

“…In studies of an unambiguous model of associative learning, harmaline blocked classical conditioning of the rabbit nictitating membrane reflex and impaired retention of that learned reflex during its tremorogenic action (Türker & Miles 1984;Harvey & Romano 1993). Another indole alkaloid, ibogaline, produces a similar tremor via the inferior olive (DeMontigny & Lamarre 1974) and its tremor‐producing analogue, ibogaine, impairs spatial learning (Kesner et al . 1995).…”

Section: Introductionmentioning

confidence: 99%

Systemic harmaline blocks associative and motor learning by the actions of the inferior olive

Welsh

1998

Eur J of Neuroscience

View full text Add to dashboard Cite

Is there a role for the inferior olive in learning? Novel paradigms of conditioning involving tongue protrusion were developed using the rat to test whether: (a) the indole alkaloid harmaline blocks associative learning via actions within the inferior olive, and (b) the inferior olive is required for associative and motor learning. Harmaline blocked associative learning as measured by the absence of conditioned responses to a tone over six daily sessions of conditioning and the absence of retention without harmaline. Harmaline's effect on associative learning was completely blocked by prior removal of the inferior olive with 3‐acetylpyridine. Rats whose inferior olives were chronically lesioned showed normal associative learning, normal associative memory, and could learn to modify tongue protrusion via a motor learning paradigm involving response shaping. Removal of the inferior olive degraded the performance of the licking motor system by increasing the latency of conditioned tongue protrusions and by increasing the temporal variability of rhythmic licking elicited by intraoral water. The experiments raise doubt as to whether the inferior olive encodes memory in the cerebellum but demonstrate that the inferior olive is essential for the temporal precision of movement. The results indicate that harmaline's antilearning action is produced by its ability to exaggerate the normal propensity of olivary neurons to fire rhythmically, a process that must be constrained under physiological conditions for normal learning to occur. It is concluded that there may be an important role for the rhythmic activity of inferior olivary neurons in the temporal processes that underlie both motor control and learning.

show abstract

Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats

Cited by 24 publications

References 18 publications

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

Acute inactivation of the inferior olive blocks associative learning

Systemic harmaline blocks associative and motor learning by the actions of the inferior olive

Contact Info

Product

Resources

About