Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen

Du, Mingyuan; Wang, Yunlong; Liu, Zhijian; Wang, Leilei; Cao, Zhengguo; Zhang, Chen; Hao, Yunru; He, Hong

doi:10.1007/s10753-018-00951-6

Cited by 29 publications

(16 citation statements)

References 49 publications

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“…[55][56][57][58] IL-1β upregulates MMP-9 expression in various cell types involved in periodontal inflammation, including osteoblasts, osteoclasts, neutrophils, and cementoblasts. 59,60 In addition, IL-1β stimulated the production of other MMPs, e.g., MMP-1 and/or MMP-3, in human periodontal ligament cells and gingival fibroblast cells. [61][62][63] The receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) system regulates osteoclastogenesis.…”

Section: The Role Of Il-1β In Periodontitismentioning

confidence: 99%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

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Section: The Role Of Il-1β In Periodontitismentioning

confidence: 99%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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“…The important role that MMP-9 plays in reactive processes including inflammation and wound repair explains why the enzyme is constitutively expressed only by a few cell types, such as neutrophils and macrophages [ 4 , 17 ]. Other cells (including fibroblasts, osteoblasts and epithelial, endothelial, dendritic and T cells) produce MMP-9 primarily upon stimulation with inflammatory cytokines, chemokines, or growth factors [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Among the inducers of MMP-9 expression are interleukin-1, tumor necrosis factor α, epidermal growth factor, transforming growth factor β1, vascular endothelial growth factor (VEGF) and the CXC chemokine ligand 12 (CXCL12) ( Figure 1 ) [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Mmp-9 Production or Activity Is Regulated At Multiple Levmentioning

confidence: 99%

“…In this context, it should be stressed that similarly to MMP-2, but in contrast with the other members of the family, MMP-9 has a specific collagen-binding domain in its catalytic site [ 4 , 25 , 26 ]. Through this domain, the enzyme binds and further cleaves the soluble monomers of interstitial collagens which result from ECM degradation started by MMP-1, MMP-8 or MMP-13 [ 2 , 3 , 18 ]. MMP-9 is also capable of directly digesting elastin, fibronectin or proteoglycans, which contributes to the dissolution of the interstitial matrix [ 27 , 28 , 29 ].…”

Section: Mmp-9 Production or Activity Is Regulated At Multiple Levmentioning

confidence: 99%

“…The wide spectrum of MMP-9 substrates enables the enzyme to influence several biological processes [ 4 , 7 , 12 , 13 , 18 , 23 , 30 , 31 , 32 , 33 ]. For this reason, MMP-9 production and activity are tightly regulated at the transcriptional, posttranscriptional, translational and posttranslational levels, as well as by endogenous serum or tissue inhibitors.…”

Section: Mmp-9 Production or Activity Is Regulated At Multiple Levmentioning

confidence: 99%

“…Regarding the MMP-9 gene expression, the promoter region of mmp-9 gene contains response elements for transcription factors including Activator Protein-1, Specificity protein-1 and Nuclear Factor-kappa B (NF-kB), as well as Ets-1 binding sites; this renders MMP-9 inducible by either inflammatory mediators or growth factors, as mentioned ( Figure 1 ) [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 34 , 35 , 36 ].…”

Section: Mmp-9 Production or Activity Is Regulated At Multiple Levmentioning

confidence: 99%

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The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor arose. Disseminated cancer cells retain the phenotypic features of the primary tumor, and display very poor differentiation indices and functional regulation. Upon arrival at the target organ, they replace preexisting, normal cells, thereby permanently compromising the patient’s health; the metastasis can, in turn, metastasize. The spread of cancer cells implies the degradation of the extracellular matrix by a variety of enzymes, among which the matrix metalloproteinase (MMP)-9 is particularly effective. This article reviews the available published literature concerning the important role that MMP-9 has in the metastatic process. Additionally, information is provided on therapeutic approaches aimed at counteracting, or even preventing, the development of metastasis via the use of MMP-9 antagonists.

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A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration

et al. 2022

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The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation, reactive oxygen species (ROS), and overexpression of proteinases (such as matrix metalloproteinases, MMPs). A “diagnostic” and therapeutic dual‐logic‐based hydrogel for diabetic bone regeneration is therefore developed through the design of a double‐network hydrogel consisting of phenylboronic‐acid‐crosslinked poly(vinyl alcohol) and gelatin colloids. It exhibits a “diagnostic” logic to interpret pathological cues (glucose fluctuation, ROS, MMPs) and determines when to release drug in a diabetic microenvironment and a therapeutic logic to program different cargo release to match immune‐osteo cascade for better tissue regeneration. The hydrogel is also shown to be mechanically adaptable to the local complexity at the bone defect. Furthermore, the underlying therapeutic mechanism is elucidated, whereby the logic‐based cargo release enables the regulation of macrophage polarization by remodeling the mitochondria‐related antioxidative system, resulting in enhanced osteogenesis in diabetic bone defects. This study provides critical insight into the design and biological mechanism of dual‐logic‐based tissue‐engineering strategies for diabetic bone regeneration.

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Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen

Cited by 29 publications

References 49 publications

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration

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