Effects of IL-22 on cardiovascular diseases

Che, Yang; Su, Zhaoliang; Xia, Lin

doi:10.1016/j.intimp.2020.106277

Cited by 20 publications

(8 citation statements)

References 92 publications

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“…The function of IL-22 in atherosclerosis is largely unknown, although evidence suggests that IL-22 is involved in vascular remodeling by promoting pro-inflammatory chemokines and antimicrobial peptide secretion as well as increasing VSMC migration and proliferation ( Figure 1 ) ( 159 , 160 ). In addition, IL-22 regulates adhesion molecule expression by ECs such as ICAM1 and VCAM1 as well as the production of chemokine ligands that have been implicated in adhesion, migration and recruitment of monocytes in atherogenesis ( Figure 1 ) ( 103 – 105 ) ( Table 3 ).…”

Section: Cytokinesmentioning

confidence: 99%

Inflammatory Mediators in Atherosclerotic Vascular Remodeling

Evans

Yerly

Vorst

et al. 2022

Front. Cardiovasc. Med.

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Atherosclerotic vascular disease remains the most common cause of ischemia, myocardial infarction, and stroke. Vascular function is determined by structural and functional properties of the arterial vessel wall, which consists of three layers, namely the adventitia, media, and intima. Key cells in shaping the vascular wall architecture and warranting proper vessel function are vascular smooth muscle cells in the arterial media and endothelial cells lining the intima. Pathological alterations of this vessel wall architecture called vascular remodeling can lead to insufficient vascular function and subsequent ischemia and organ damage. One major pathomechanism driving this detrimental vascular remodeling is atherosclerosis, which is initiated by endothelial dysfunction allowing the accumulation of intimal lipids and leukocytes. Inflammatory mediators such as cytokines, chemokines, and modified lipids further drive vascular remodeling ultimately leading to thrombus formation and/or vessel occlusion which can cause major cardiovascular events. Although it is clear that vascular wall remodeling is an elementary mechanism of atherosclerotic vascular disease, the diverse underlying pathomechanisms and its consequences are still insufficiently understood.

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Section: Cytokinesmentioning

confidence: 99%

Inflammatory Mediators in Atherosclerotic Vascular Remodeling

Evans

Yerly

Vorst

et al. 2022

Front. Cardiovasc. Med.

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“…This difference may be caused by the difference inreceptor R1. The binding of SRC homologous phosphatase 2 (Shp2) to Tyr-251 phosphorylation residues and the activation of IL-22R1 on Tyr-301 are necessary for the activation of STAT3 (39,44). Moreover, the phosphorylation of STAT3 is essential for IL-22 to exert its effects on epithelial cells (45).…”

Section: Characteristics Of Th22 Cellsmentioning

confidence: 99%

Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

et al. 2021

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Upon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets. Th22 cells secrete certain cytokines such as IL-22, IL-13 and TNF-α, but not others, such as IL-17, IL-4, or interferon-γ (IFN-γ), and they express chemokine receptors CCR4, CCR6 and CCR10. Th22 cells were initially found to play a role in skin inflammatory diseases, but recent studies have demonstrated their involvement in the development of various autoimmune diseases. Here, we review research advances in the origin, characteristics and effector mechanisms of Th22 cells, with an emphasis on the role of Th22 cells and their main effector cytokine IL-22 in the pathogenesis of autoimmune diseases. The findings presented here may facilitate the development of new therapeutic strategies for targeting these diseases.

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“…Generally, innate immune cells respond directly to local environment and quickly modulate surrounding epithelial host defense in the early state, while T cells induce strong and sustained immune responders in the late state. ILCs were supposed as the main producer of IL-22 in mucosa, while Th cells were believed as the primary sources of IL-22 in epithelial tissues ( 64 ). ILCs initiated inflammatory response rapidly after stimulation by IL-23 in psoriatic mice ( 65 ).…”

Section: Biological Activities Of Th22 Cells and Il-22 In The Skinmentioning

confidence: 99%

The Role of T Helper 22 Cells in Dermatological Disorders

Pan

Wang

et al. 2022

Front. Immunol.

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T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway.

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Effects of IL-22 on cardiovascular diseases

Cited by 20 publications

References 92 publications

Inflammatory Mediators in Atherosclerotic Vascular Remodeling

Inflammatory Mediators in Atherosclerotic Vascular Remodeling

Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

The Role of T Helper 22 Cells in Dermatological Disorders

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