Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Liu, Huijun; Zhang, Xiaoqiang; Chen, Caidong; Du, Sheng; Dong, Ying

doi:10.1016/j.ecoenv.2015.07.010

Cited by 71 publications

(34 citation statements)

References 48 publications

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“…These results indicated that [C 8 mim]Br had toxic effects on the growth S. costatum at high concentrations. Similar results have also been described for the Baltic algae Oocystis submarina treated with [C 6 mim]BF 4 (Latała et al, 2005), and Scenedesmus obliquus treated with [C 8 mim]Cl (Liu et al, 2015). The growth of O. submarina and S. obliquus could be recovered by increasing exposure time at low concentrations, but not at high concentrations of ILs.…”

Section: Growth Inhibition Of S Costatum By [C 8 Mim]brsupporting

confidence: 85%

“…In this study, the 24, 48, 72 and 96 h EC 50 values were 24.4, 17.9, 39.7, 39.9 mg L À 1 , respectively, which suggested that the toxicity of [C 8 mim]Br increased first and then decreased with increasing exposure time, reaching its maximum toxicity at 48 h. The maximum toxic effects of [C 8 mim]Cl was also presented at 48 h against S. obliquus, while it was more toxic to S. obliquus than [C 8 mim]Br (Liu et al, 2015). Previous reports indicated that an exposure time of 48 h is the most sensitive for algal growth inhibition tests, and its sensitivity is 0.25 log units greater than those of the 72 and 96 h of exposure (Fu et al, 2015).…”

Section: Growth Inhibition Of S Costatum By [C 8 Mim]brmentioning

confidence: 74%

See 1 more Smart Citation

Growth inhibition and oxidative stress induced by 1-octyl-3-methylimidazolium bromide on the marine diatom Skeletonema costatum

Deng

Cheng

et al. 2016

Ecotoxicology and Environmental Safety

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Section: Growth Inhibition Of S Costatum By [C 8 Mim]brsupporting

confidence: 85%

Section: Growth Inhibition Of S Costatum By [C 8 Mim]brmentioning

confidence: 74%

Growth inhibition and oxidative stress induced by 1-octyl-3-methylimidazolium bromide on the marine diatom Skeletonema costatum

Deng

Cheng

et al. 2016

Ecotoxicology and Environmental Safety

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“…As depicted, [Amim]Cl, [Emim]Cl, and [Bmim]Cl had little impact on the cell membrane integrity, as the PI uptake of cells in the presence of these ILs was identical to that in the absence of IL (3%). Liu et al observed that the effect of IL ([ C n mim]Cl, n ≥ 8) on the cellular membrane permeability of Scenedesmus obliquus increased with chain length, and IL with longer alkyl chain lengths tended to possess stronger lipophilicity, which increased the chance of contact with the lipid bilayer and hydrophobic proteins of the membrane [39]. However, no such relationship was found in our study.…”

Section: Resultscontrasting

confidence: 72%

Mechanistic insights into the effect of imidazolium ionic liquid on lipid production by Geotrichum fermentans

Liu

Zong

Linhardt

et al. 2016

Biotechnol Biofuels

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BackgroundIonic liquid (IL) pretreatment has emerged as a promising technique that enables complete utilization of lignocellulosic biomass for biofuel production. However, imidazolium IL has recently been shown to exhibit inhibitory effect on cell growth and product formation of industrial microbes, such as oleaginous microorganisms. To date, the mechanism of this inhibition remains largely unknown.ResultsIn this study, the feasibility of [Bmim][OAc]-pretreated rice straw hydrolysate as a substrate for microbial lipid production by Geotrichum fermentans, also known as Trichosporon fermentans, was evaluated. The residual [Bmim][OAc] present in the hydrolysate caused a reduction in biomass and lipid content (43.6 and 28.1%, respectively) of G. fermentans, compared with those of the control (7.8 g/L and 52.6%, respectively). Seven imidazolium ILs, [Emim][DEP], [Emim]Cl, [Amim]Cl, [Bmim]Cl, [Bzmim]Cl, [Emim][OAc], and [Bmim][OAc], capable of efficient pretreatment of lignocellulosic biomass were tested for their effects on the cell growth and lipid accumulation of G. fermentans to better understand the impact of imidazolium IL on the lipid production. All the ILs tested inhibited the cell growth and lipid accumulation. In addition, both the cation and the anion of IL contributed to IL toxicity. The side chain of IL cations showed a clear impact on toxicity. On examining IL anions, [OAc]− was found to be more toxic than those of [DEP]− and Cl−. IL exhibited its toxicity by inhibiting sugar consumption and key enzyme (malic enzyme and ATP-citrate lyase) activities of G. fermentans. Cell membrane permeability was also altered to different extents in the presence of various ILs. Scanning electron microscopy revealed that IL induces fibrous structure on the surface of G. fermentans cell, which might represent an adaptive mechanism of the yeast to IL.ConclusionsThis work gives some mechanistic insights into the impact of imidazolium IL on the cell growth and lipid accumulation of oleaginous yeast, which is important for IL integration in lignocellulosic biofuel production, especially for microbial lipid production.Electronic supplementary materialThe online version of this article (doi:10.1186/s13068-016-0682-z) contains supplementary material, which is available to authorized users.

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“…The resultss uggest variable entrance into the cells through the phospholipidb ilayer of the membrane owing to differences in the lypophilicities of the ILs and the composition and/or specificity of the composition of the membrane in terms of membrane receptors, proteins, cholesterol, or fatty acids. The effect of 1-alkyl-3-imidazolium-basedI Ls on the ultrastructure of Scenedesmus obliquus has been evaluated by Liu et al, [157] and the obtained results show an increase in the inhibition of growth rate with an increase in the concentration of the IL, an increase in the lengthofthe alkyl chain, and an increase in the exposure time. Studies conducted to assess the effectso ft he selectedI Ls on the permeability of the cellular membrane demonstrate that the cell wall of the green algae becomes wavy and separated from the cell membrane.…”

Section: Aquatic Toxicitymentioning

confidence: 99%

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

et al. 2017

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This Review aims to integrate the most recent and pertinent data available on the (bio)degradability and toxicity of ionic liquids for global and critical analysis and on the conscious use of these compounds on a large scale thereafter. The integrated data will enable focus on the recognition of toxicophores and on the way the community has been dealing with them, with the aim to obtain greener and safer ionic liquids. Also, an update of the most recent biotic and abiotic methods developed to overcome some of these challenging issues will be presented. The review structure aims to present a potential sequence of events that can occur upon discharging ionic liquids into the environment and the potential long-term consequences.

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Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus

Cited by 71 publications

References 48 publications

Growth inhibition and oxidative stress induced by 1-octyl-3-methylimidazolium bromide on the marine diatom Skeletonema costatum

Growth inhibition and oxidative stress induced by 1-octyl-3-methylimidazolium bromide on the marine diatom Skeletonema costatum

Mechanistic insights into the effect of imidazolium ionic liquid on lipid production by Geotrichum fermentans

Environmental Impact of Ionic Liquids: Recent Advances in (Eco)toxicology and (Bio)degradability

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