Effects of immunosuppression by cyclosporine A on allogenic uterine transplant in the rat

Alternations of galectin levels after renal transplantation

“…Until now, data about the effects of immunosuppressive drugs on the expression of gals have been very scarce. A recent study demonstrated that the mRNA levels of gal-1 were decreased in the rejected uteri and were higher in the CsA-treated [30]. However, there are some investigations on the effects of statins on the expressions of gals.…”

Expression of lymphocyte coding genes in peripheral blood and lymphocyte infiltration in cardiac tissues influenced by cyclosporin A in heterotopic heart transplantation model in rats

“…T cell antigen receptor (TCR) interacts with antigen presenting cells (APC) expressing ligand MHC peptide, which leads to TCR-ζ intracellular region to phosphorylate phosphate tyrosine kinase to transmit immunological signals in T cells to induce signal transduction to activate T cells. Tyrosine phosphorylation is the initial signal necessary for T cell activation [12][13][14].…”

Custodiol-N Is Superior to Custodiol® Solution in Experimental Rat Uterus Preservation

“…Uterus transplantation (UTx) is the first and only available treatment for absolute uterine factor infertility (AUFI). Up to 7% of women suffer from AUFI [1,2], which is linked to either congenital uterine agenesis (Mayer-Rokitansky-Küster-Hauser syndrome), major congenital uterine malformation (hypoplastic uterus, fraction of bicornuate/unicornuate uterus), a surgically absent uterus, or an acquired condition (intrauterine adhesions, leiomyoma) related to uterine malfunction that causes implantation failure or defect placentation [3].…”