Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats

Tomofuji, Takaaki; Ekuni, Daisuke; Sanbe, Toshihiro; Azuma, Tetsuji; Tamaki, Naofumi; Irie, Koichiro; Maruyama, Takayuki; Yamamoto, Tatsuo; Watanabe, Tatsuo; Miyauchi, Mutsumi; Takata, Takashi

doi:10.1080/00016350902794818

Cited by 26 publications

(35 citation statements)

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“…It has been reported that GGT blood levels were positively associated with attachment level in alcoholic persons, but not in non-alcoholic persons [24]. On the other hand, there are some reports about a relationship between periodontal diseases and liver disease [25, 26]. The present data appear to support such reports.…”

Section: Discussionsupporting

confidence: 86%

Effects of periodontal treatment on the medical status of patients with type 2 diabetes mellitus: a pilot study

et al. 2017

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BackgroundStudies have demonstrated that periodontal disease is associated with the development of systemic complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this pilot study was to investigate which markers among various systemic disease parameters are affected by periodontal treatment in patients with T2DM.MethodsTwelve patients with T2DM were given oral hygiene instructions and subsequent subgingival scaling and root planing. The periodontal status was recorded, and blood and urine samples were taken to measure various parameters of glucose control and systemic status at baseline and 1 month following the periodontal treatment. Serum concentrations of tumor necrosis factor-α and high-sensitivity C-reactive protein were measured by enzyme-linked immunosorbent assay.ResultsAfter the periodontal treatment, the glycated hemoglobin value was significantly improved. The levels of urinary N-acetyl-β-D-glucosaminidase and albumin, which are markers of renal dysfunction, also decreased significantly after treatment. Among the parameters measured in serum, the γ-glutamyl transpeptidase level, which is usually interpreted as a marker of liver dysfunction, was significantly reduced. The serum concentrations of tumor necrosis factor-α and high-sensitivity C-reactive protein were also significantly reduced by periodontal treatment.ConclusionWithin the limitations of this pilot study, periodontal treatment may be effective not only in improving metabolic control, but also in reducing the risk of diabetic kidney and liver disease in patients with T2DM.

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Section: Discussionsupporting

confidence: 86%

Effects of periodontal treatment on the medical status of patients with type 2 diabetes mellitus: a pilot study

et al. 2017

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“…Oxidative stress may cause direct damage to cells and tissues, as well as stimulating production of proinflammatory cytokines . Decreasing GSH/GSSG ratio is an indicator of local alterations in gingival redox balance as well as increasing circulating oxidative stress . In this study ligature placement for lower incisors resulted in a decrease trend in the GSH/GSSG ratio (Fig.…”

Section: Discussionmentioning

confidence: 58%

“…In another study, induced‐periodontitis in rats determined oxidative damage of the liver . These observations support the possibility that periodontal disease could promote hepatic oxidative damage by increasing oxidative stress, respectively MDA and reduce GSH …”

Section: Discussionmentioning

confidence: 59%

“…In the current literature, the association between periodontal disease and liver injury has been lately reported . Several papers have demonstrated that the presence of hepatic inflammation after ligature induced periodontitis around molars .…”

Section: Discussionmentioning

confidence: 99%

“…The impact of periodontitis on general health is still unclear. It is implied that polymorphonuclear leukocytes produce reactive oxygen species (ROS) as host defense against bacterial pathogens . Excessive production of ROS has negative consequences to oxidative/anti‐oxidative balance and determines an excessive production of lipid peroxide .…”

Section: Introductionmentioning

confidence: 99%

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Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Meşter

Ciobanu

Taulescu

et al. 2019

Journal of Periodontology

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Background The aim was to assess the effects of periodontal disease in promoting liver fibrosis in a rat model of ligature‐induced periodontitis. Methods Twenty‐four Wistar rats were divided into four groups: control (CTRL), experimental periodontitis group at day 7 (PER7), at day 14 (PER14), at day 21 (PER21). Experimental periodontitis was induced by the placement of a silk ligature around mandibular incisors. The following parameters were assessed: gingival index, tooth mobility; liver status, and portal vein caliber by ultrasound examination; bone retraction, bone mineral density (BMD), bone volume/tissue volume (BV/TV) by micro‐CT analysis; aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT); oxidative stress (malondialdehyde [MDA], reduced glutathione/oxidative glutathione ratio [GSH/GSSG]), and matrix metalloproteinase‐8 (MMP‐8) levels; and histopathological evaluation of periodontal and liver tissues. Results Periodontal parameters showed the development of periodontitis in experimental groups. Micro‐CT results indicates an increase of bone retraction and BMD values and a decrease of BV/TV value in PER groups. Liver fibrosis could not be diagnosed with ultrasound examination in any of the groups. Elevated levels of ASAT and ALAT in PER groups compared with CTRL group were found. MDA have indicated elevated levels and a decrease of GSH/GSSG ratio in PER group compared with the CTRL group. Levels of MMP‐8 have indicated high values in PER21 compared with the other groups. Histological analysis of the periodontal and liver tissues sustains the link between periodontal and hepatic injury. Conclusion This study demonstrates a positive correlation between periodontal lesions and liver disease. Periodontitis may be an independent risk factor for liver fibrosis.

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Dentistry Through Life

Gawor¹,

Niemiec

2021

The Veterinary Dental Patient

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Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats

Abstract: Toothbrushing promoted healing of periodontal lesions, decreased serum lipopolysaccharide concentration and suppressed liver injury in a rat periodontitis model.

Cited by 26 publications

References 19 publications

Effects of periodontal treatment on the medical status of patients with type 2 diabetes mellitus: a pilot study

Effects of periodontal treatment on the medical status of patients with type 2 diabetes mellitus: a pilot study

Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats

Dentistry Through Life

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