Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials of Sargassum spp.

Un, Sovannary; Quan, Nguyen Van; Anh, La Hoang; Lam, Vu Quang; Takami, Akiyoshi; Khanh, Tran Dang; Xuan, Tran Dang

doi:10.3390/molecules27072307

Cited by 8 publications

(9 citation statements)

References 49 publications

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“…For example, GBR treated with B2 (75 mM salinity for 4 days) can be applied to produce a fermented functional beverage known as kombucha, which has become increasingly popular because of its health benefits [ 63 ]. On the other hand, considering the impacts of human digestion on targeted products, their bioaccessibility and bioavailability during the digestion process should be thoroughly examined in future studies [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Hasan

Quan

Anh

et al. 2023

Foods

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This is the first investigation, conducted in a completely randomized design (CRD), to determine the effects of different salinity levels (75 and 150 mM) and germination periods (3, 4, and 5 days) on momilactone and phenolic accumulations in germinated brown rice (GBR) var. Koshihikari. Particularly, the identification of bioactive compounds was confirmed using electrospray ionization-mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy (1H and 13C). Momilactone A (MA) and momilactone B (MB) amounts were determined by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry (UPLC–ESI-MS), whereas other compounds were quantified by spectrophotometry and high-performance liquid chromatography (HPLC). Accordingly, GBR under B2 treatment (75 mM salinity for 4 days) showed the greatest total phenolic and flavonoid contents (14.50 mg gallic acid and 11.06 mg rutin equivalents, respectively, per g dry weight). GBR treated with B2 also accumulated the highest quantities of MA, MB, ρ-coumaric, ferulic, cinnamic, salicylic acids, and tricin (18.94, 41.00, 93.77, 139.03, 46.05, 596.26, and 107.63 µg/g DW, respectively), which were consistent with the strongest antiradical activities in DPPH and ABTS assays (IC50 = 1.58 and 1.78 mg/mL, respectively). These findings have implications for promoting the value of GBR consumption and rice-based products that benefit human health.

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Section: Resultsmentioning

confidence: 99%

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Hasan

Quan

Anh

et al. 2023

Foods

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“…However, the use of phytochemicals with α-amylase inhibition with cytotoxic activity is well established. 53–55 Our group is also currently working on understanding the mechanisms for compounds 5e , 5f and 5y with regards to their anticancer properties, and further assess if these properties might open up the scope for their utility as anticancer or antidiabetic agents via α-amylase inhibition.…”

Section: Resultsmentioning

confidence: 99%

“…However, the use of phytochemicals with α-amylase inhibition with cytotoxic activity is well established. [53][54][55] Our group is also currently working on understanding the mechanisms for compounds…”

Section: Synthetics Exhibit Anticancer Potential Corroborated By a De...mentioning

confidence: 99%

Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: anin silicoandin vitroapproach

et al. 2023

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“…To develop them for medical and pharmaceutical purposes as well as practical applications, multiple rigorous confirmation steps are necessary. Specifically, the bioaccessibility and bioavailability of natural compounds can be influenced by human digestion, necessitating scrutiny in forthcoming research (Un et al, 2022). Furthermore, the safety of these substances must undergo careful consideration and comprehensive assessment (Teschke and Xuan, 2020).…”

Section: Perspectives On Further Exploration Of Momilactones For Huma...mentioning

confidence: 99%

Biological roles of momilactones: achievements, challenges, and promising approaches to exploit their beneficial properties

Anh,

Khanh,

Xuan

2023

Front. Nat. Prod.

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Momilactones are defined as every lactone derived from rice husk. To date, these compounds can only be naturally found in rice (Oryza lineage) and moss (Pseudoleskeella papillosa and Hypnum plumaeforme). Their basic structure refers to the (9β-H)-pimarane skeleton bearing a γ-butyrolactone. In this review, the beneficial properties of momilactones, especially momilactones A (MA) and B (MB), including allelopathy, antimicrobials, antioxidants, anti-chronic diseases, anti-inflammation, and anticancer, are highlighted. Additionally, the signaling roles of momilactones in the response of host plants against environmental stresses are discussed, raising the question of whether momilactones act as novel phytohormones that require further comprehensive clarification. In another aspect, we come up with promising approaches to the future exploitation of these valuable compounds based on the current knowledge of their bioactivity mechanisms, biosynthetic pathways, and isolation protocols. However, momilactone biosynthetic processes remain elusive. Moreover, challenges in researching these compounds are mainly due to difficulties in isolation procedures and the lack of commercial sources, which have been least improved over the last half-century. Accordingly, we propose promising strategies to address these present problems and promote the effectiveness of further research, including: i) to improve the efficiency of momilactone extraction and isolation from plant sources; ii) to increase momilactone production applying synthetic models; iii) to generate crops that accumulate greater momilactone contents through genetic engineering approaches; iv) to discover new applications that combine momilactones with other prospective substances for enhancing targeted biological properties and preventing undesirable impacts; and v) to employ smart farming for optimizing the application of momilactones, monitoring their levels, and promoting sustainable agriculture. This paper may provide valuable insights for future strategies, focusing on the exploitation of momilactones for human health-beneficial purposes and the development of green agriculture aligned with sustainable development targets.

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Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials of Sargassum spp.

Cited by 8 publications

References 49 publications

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: anin silicoandin vitroapproach

Biological roles of momilactones: achievements, challenges, and promising approaches to exploit their beneficial properties

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