Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits

Sepici-Dinçel, Aylin; Açıkgöz, Şereften; Çevi̇k, Cemal; Şengelen, Meltem; Yeşilada, Erdem

doi:10.1016/j.jep.2006.10.015

Cited by 99 publications

(65 citation statements)

References 29 publications

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“…In diabetes mellitus, hyperglycemia can simply inactivate antioxidant enzymes such as SOD, CAT and GPX by glycating these proteins and induces oxidative stress which in turn causes lipid peroxidation (Vincent et al, 2004;Kaleem et al, 2006). Decreased antioxidant enzymes levels and enhanced lipids peroxidation have been well documented in alloxan-induced diabetes (Sepici-Dincel et al, 2007;Oyedemi et al, 2011;Monavar et al, 2010). In the enzymatic antioxidant defense system, SOD is one of the important enzymes and scavenges the superoxide radicals by converting them to H 2 O 2 and molecular oxygen.…”

Section: Effect On Liver Dysfunction Indicesmentioning

confidence: 99%

Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

et al. 2015

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Hyperglycemia exerts toxic effects on the pancreatic β-cells. This study investigated the hypothesis that the antidiabetic drugs glibenclamide and metformin, in combination with hydroxychloroquine (HCQ) offer additional protection for the pancreas against oxidative stress and produce hepatoprotective effect in alloxan-induced diabetic rats. Diabetes was induced in male Long-Evans rats by a single dose of alloxan (120 mg/kg; i.p.). Different groups of diabetic animals were treated with glibenclamide (10 mg/70 kg, i.p.), metformin (850 mg/70 kg, i.p.), HCQ (300 mg/70 kg, i.p.) and combination of both glibenclamide and metformin with HCQ, separately for a period of 28 days. Diabetic rats had significantly elevated levels of serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), while catalase (CAT) and superoxide dismutase (SOD) activity were significantly reduced. Glibenclamide and metformin produced no significant effects on antioxidant enzymes but both showed significant (p<0.05) result in reducing SGOT and SGPT level in diabetic rats. In contrast, the combination of glibenclamide or metformin with HCQ showed better effect on up-regulation of CAT and SOD activity and down-regulation of SGOT and SGPT activity in comparison with the antidiabetic drug alone. These findings suggest that, HCQ potentiates the effect of glibenclamide and metformin to protect pancreas against oxidative stress and produce hepatoprotective effect in diabetic rats.

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Section: Effect On Liver Dysfunction Indicesmentioning

confidence: 99%

Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

et al. 2015

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“…For example, Allium cepa (garden onion) and Momordica charantia (bitter melon) have hypoglycemic effects (13,17,24) and improved insulin action in rats fed a high-fat diet (17), while the medicinal plant, Galega officialis, led to discovery and synthesis of metformin, the well-known hypoglycemic medication (64). Essential (volatile) oils of herbs and medicinal plants have long been known to have antimicrobial, antifungal, and antioxidant properties (10,60), as well as exerting hypoglycemic effects in animal models of type 1 diabetes (54,55), type 2 diabetes (Zucker fatty rats), and insulin resistance (59). Thus, it appears that essential oils offer therapeutic potential for the treatment of insulin resistance, although their mechanism of action remains unknown.…”

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confidence: 99%

Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle

Alkhateeb

Bonen

2010

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In diabetes an increase in oxidative stress arises due to compromise in natural antioxidant mechanisms and an increase in oxygen free radical production (El-Demerdash et al, 2005). Any compound-natural or synthetic-with antioxidant activity might totally or partly alleviate the oxidative damage (Sepici-Dincel et al, 2007). SOD and CAT are the two major scavenging enzymes that remove radicals in vivo.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

Al–Fartosy

2015

American Journal of Biochemistry and Biotechnology

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Lycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found to be non-toxic at 1000 mg kg −1 , as no deaths or hazardous signs were recorded during treatment or the observation period (24 and 72 h) in either control or treated groups of mice. In GLBF (500 mg kg −1 ), the onset was 4 h, the peak effect was 6 h but the effect waned at 24 h. In the chronic study, repeated administration (once a day for 21 days) of the glibenclamide and GLBF caused a significant reduction in the serum glucose level as compared to the diabetic control group. GLBF (500 mg kg −1 ) treatment prevented a decrease in the body weight of the diabetic rats. Moreover, the results revealed that GLBF (500 mg kg −1 ) treatment for 21 days significantly (p<0.01) reduced the levels of lipid profile, lipid peroxidation, improving kidney and liver functions, enhanced insulin level and increased the levels of enzymatic and non-enzymatic antioxidants. The findings in this study suggest that polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) possess good pharmacological activities, which might be helpful in controls the blood glucose level, improves body weight, lipid metabolism and prevents diabetic complications associated with lipid peroxidation and also maintains the antioxidant enzymatic and nonenzymatic in experimental diabetic rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus.

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Effects of in vivo antioxidant enzyme activities of myrtle oil in normoglycaemic and alloxan diabetic rabbits

Cited by 99 publications

References 29 publications

Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

Antidiabetics in combination with hydroxychloroquine improve antioxidant and hepatoprotective activities in alloxan-induced diabetic rats

Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle

Protective Effect of Galactomannan Extracted from Iraqi <i>Lycium barbarum</i> L. Fruits against Alloxan-Induced Diabetes in Rats

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