The difficulties of tobacco waste management during production provide the context for the research. Tobacco waste, including stems, stalks, and other by-products, can be a significant environmental problem, even though sustainable methods are essential. Tobacco waste reuse is an area that needs further research. Thus, this study will examine how GHP, worker salaries, and biotech innovation relate. The study, which used a quantitative approach, was conducted in Gatak District, Sukoharjo Regency, Central Java, involving 50 active tobacco farm workers selected through simple random sampling. Data were collected through surveys, questionnaires, and in-depth interviews and analyzed using linear and multinomial logit regression. The findings indicate that age, education, experience, waste sorting, waste processing, field school participation, and biotechnology training significantly influence worker wages and the likelihood of innovation in biotechnological applications. The study highlights the importance of education, training, and effective waste management practices in promoting sustainable innovation in the tobacco industry.