Effects of increased intracellular Ca2+ on cyclic nucleotides production by liver tissue

Anghileri, L. J.; Heidbreder, M

doi:10.1007/bf01922183

Experientia

1977

DOI: 10.1007/bf01922183

|View full text |Cite

Effects of increased intracellular Ca2+ on cyclic nucleotides production by liver tissue

L. J. Anghileri

M Heidbreder

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1980

1990

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent report on the effect of glucagon and dibutyryl cAMP on hepatocytes claimed that the observations supported the idea that cAMP causes efflux of Ca from mitochondria [6]. During hepatointoxication the rise in cAMP was postulated to modulate the rise of intracellular Ca 2 § [1].…”

mentioning

confidence: 95%

New evidence for the role of cyclic AMP in the release of mitochondrial calcium

Juzu

Holdsworth

1980

J. Membrain Biol.

View full text Add to dashboard Cite

mentioning

confidence: 95%

New evidence for the role of cyclic AMP in the release of mitochondrial calcium

Juzu

Holdsworth

1980

J. Membrain Biol.

View full text Add to dashboard Cite

“…Elevated levels of cytosolic Ca2+ (1,2) and Ca2+-binding proteins (3)(4)(5)(6) are present in transformed cells and may be responsible for their uncontrolled proliferation and sometimes increased motility. Therefore, we analyzed for the presence of parvalbumin and structurally related Ca2+-binding proteins three human epidermoid carcinoma cell lines [LICR(Lond-HN 1, -HN 2, and -HN 6], known to express different modes of motility (7)(8)(9).…”

mentioning

confidence: 99%

Calcium-binding proteins in human carcinoma cell lines.

Pfyffer¹,

Haemmerli²,

Heizmann³

1984

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Elevated levels of Ca2+-binding proteins are reported in transformed cells and thought to be involved in their uncontrolled proliferation and often increased motility.Therefore, three cell-lines [LICR(Lond)-HN 1, -HN 2, and -HN 6] derived from human carcinomas displaying various degrees of locomotive activity were investigated for the presence of parvalbumin and related Ca2+-binding proteins. By applying different immunohistochemical methods in conjunction with a monospecific anti-parvalbumin antiserum, an intense staining was seen in cells displaying translocative motility. Often in these cells, an association with filamentous structures located in the nuclear region was observed. Unique Ca2 -binding proteins, absent from comparable normal tissue, were found in the malignant cell lines when analyzed by two-dimensional polyacrylamide gel electrophoresis and high-performance liquid chromatography. From these tumor cells a protein (Mr, 12,000; pI, 4.8) was isolated that crossreacted with antiparvalbumin antiserum. Peptide maps of this protein revealed a further structural homology to parvalbumin (Mr,12,000; pl, 4.9). In analogy to muscle, where there is evidence for a regulatory role of parvalbumin in the contraction-relaxation cycle, we speculate that this protein is tumor-associated and connected to the motile behavior of carcinoma cells.

show abstract

Increased content of calmodulin in morris hepatoma 5123 t.c.(h)

Wei

Hickie

1981

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effects of increased intracellular Ca2+ on cyclic nucleotides production by liver tissue

Cited by 4 publications

References 8 publications

New evidence for the role of cyclic AMP in the release of mitochondrial calcium

New evidence for the role of cyclic AMP in the release of mitochondrial calcium

Calcium-binding proteins in human carcinoma cell lines.

Increased content of calmodulin in morris hepatoma 5123 t.c.(h)

Contact Info

Product

Resources

About