Effects of Indigenous Enterococci on the Intestinal Microbiota and the Behavior of Rats on Correction of Experimental Dysbiosis

Ermolenko, E. I.; Абдурасулова, И. Н.; Kotyleva, M. P.; Svirido, D. A.; Мацулевич, А. В.; Karaseva, Alena; Tarasova, E. Yu.; Sizov, V. V.; Suvorov, Alexander

doi:10.1007/s11055-018-0591-7

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The use of autoprobiotics did not reveal significant differences in the composition of the gut microbiota after administration of probiotic E. faecium L3. The advantage of autoprobiotic can be the duration of the effect of autoprobiotics, established earlier [12].…”

Section: Discussionmentioning

confidence: 99%

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The clinical effectiveness of probiotics and autoprobiotics in treatment of <i>Helicobacter pylori</i>-associated dyspepsia

Ermolenko

Молостова

Барышникова

et al. 2022

Russian Journal of Infection and Immunity

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The aim of our study was to evaluate the clinical performance of a monotherapy by Enterococcus faecium-based probiotics and indigenous autoprobiotics against H. pylori associated dyspepsia. Materials and methods. There were examined 95 patients with dyspepsia. The entire patient cohort underwent clinical evaluation including filling out the questionnaire to assess dyspepsia symptoms before and after treatment, gastric endoscopy as well as gastric multi-focal biopsy (gastric body and gastric antrum) and verification of H. pylori infection with the three clinical laboratory methods (biochemical, bacteriological and molecular detection). An antagonistic in vitro activity of probiotics against H. pylori was detected by drop plate method for probiotic strains Enterococcus faecium SF68 and Bifidobacterium bifidum (Bifiform), Enterococcus faecium L3 (Laminolact), and autoprobiotic strains combined with indigenous Enterococcus faecium. To examine an antagonistic activity of probiotics and autoprobiotics in clinical trials, we used a starter culture based on the Enterococcus faecium L3 strain and an autoprobiotic based on indigenous Enterococcus faecium. The probiotic or autoprobiotic were administered orally to patients with gastritis twice a day at dose of 50 ml (8.0 lgCFU/ml) for 20 days. H. pylori eradication was assessed by stool antigen test 1.52 months after the end of treatment. Results. Initially the H. pylori infection was confirmed with 49.4% of patients. The sensitivity of H. pylori to the probiotics was detected in 81% of individuals for indigenous Enterococci (the autoprobiotic), 76% for Laminolact, and in 62% for Bifiform. 22 patients with previous history of allergic reactions to antibiotics used in routine H. pylori eradication regimens were divided in two cohorts. One cohort (10 patients) received the autoprobiotic only, another cohort (12 patients) received only probiotic. Monotherapy with autoprobiotic resulted in 100% H. pylori eradication, single-agent therapy with probiotic led to 60% eradication of H. pylori. Dyspepsia symptoms were completely resolved in both groups of patients. Conclusion. Our research demonstrated the sensitivity of examined H. pylori strains to be similar for traditional eradication treatment agents (antibiotics) and the proposed intervention agents (probiotics and autoprobiotics). An autoprobiotic monotherapy with indigenous enterococci led to higher levels of H. pylori eradication than with E. faecium L3-based probiotic agent. Our work demonstrated advantage for application of probiotics in patients with antibiotic allergies or other obstacles for the standard eradication therapy. Nonetheless, further investigation to better understand underlying mechanisms of action, as well as larger observational and randomized studies, are necessary to determine the scope of therapeutic application for probiotics and autoprobitics to eradicate H. pylori infection.

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Section: Discussionmentioning

confidence: 99%

“…and autoprobiotics based on E. coli) in treating dysbiotic disorders caused by the use of antibacterial drugs [1,8], as well as indigenous strains of Enterococcus spp. in the treatment of intestinal pathology and neurological diseases [12].…”

Section: Introductionmentioning

confidence: 99%

The clinical effectiveness of probiotics and autoprobiotics in treatment of <i>Helicobacter pylori</i>-associated dyspepsia

Ermolenko

Молостова

Барышникова

et al. 2022

Russian Journal of Infection and Immunity

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“…Experimental studies utilizing autoprobiotics have demonstrated that in rats with antibiotic-associated dysbiosis, the administration of different indigenous strains of bacteria (such as bifidobacteria, enterococci, or a bacterial mixture) resulted in a rapid restoration of the microbiota compared to untreated animals[ 86 , 90 ]. Several clinical studies have already shown the effectiveness of autoprobiotics based on indigenous strains of Lactobacillus spp.…”

Section: What Are Autoprobiotics?mentioning

confidence: 99%

“…Several clinical studies have already shown the effectiveness of autoprobiotics based on indigenous strains of Lactobacillus spp. in restoring and stabilizing the levels of key representatives of the normal intestinal microbiota (such as Bifidobacterium spp., Lactobacillus spp., and E. coli ) in dysbiotic disorders caused by antibiotic usage[ 91 - 93 ], as well as in infection and inflammatory diseases[ 86 , 90 , 94 ]. The efficacy of monotherapy using autoprobiotics based on indigenous non-pathogenic enterococci has been demonstrated in the treatment of chronic gastritis associated with H. pylori : The eradication rate was 80%, and there was 100% relief of symptoms after a 20-d autoprobiotic treatment[ 95 ].…”

Section: What Are Autoprobiotics?mentioning

confidence: 99%

Probiotics and autoprobiotics for treatment of Helicobacter pylori infection

Baryshnikova,

Ilina,

Ermolenko

et al. 2023

World J Clin Cases

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Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.

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Evaluation of the Efficacy of Enterococcus faecium L3 as a Feed Probiotic Additive in Chicken

Suvorov

Zhao

Leontieva

et al. 2022

Probiotics & Antimicro. Prot.

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Effects of Indigenous Enterococci on the Intestinal Microbiota and the Behavior of Rats on Correction of Experimental Dysbiosis

Cited by 5 publications

References 25 publications

The clinical effectiveness of probiotics and autoprobiotics in treatment of <i>Helicobacter pylori</i>-associated dyspepsia

The clinical effectiveness of probiotics and autoprobiotics in treatment of <i>Helicobacter pylori</i>-associated dyspepsia

Probiotics and autoprobiotics for treatment of Helicobacter pylori infection

Evaluation of the Efficacy of Enterococcus faecium L3 as a Feed Probiotic Additive in Chicken

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