Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics

Jung, Jesse J.; Soh, Yu Qiang; Sha, Patricia; Yu, Sophia; Durbin, Mary K; Hoang, Quan V.

doi:10.1016/j.ajo.2020.07.005

Cited by 12 publications

(15 citation statements)

References 50 publications

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“…Small amount of VD changes has been reported for 1 D of astigmatism increase. 30 Signal strength can affect accurate data analysis. 31 In fact, for accurate data analysis, RTVue (Optovue, Fremont, CA) recommends $45 in the signal strength index for macular patterns and $35 for retinal scanning, on a scale from 0 to 100.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography Evaluation of Peripapillary Microvascular Changes After Rhegmatogenous Retinal Detachment Repair

Bonfiglio

Ortisi

Nebbioso³

et al. 2021

Retina

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Purpose: To evaluate the radial peripapillary capillary plexus (RPCP) vessel density (VD) and the retinal nerve fiber layer (RNFL) thickness in eyes successfully treated with pars plana vitrectomy for primary rhegmatogenous retinal detachment.Methods: In this cross-sectional multicenter clinical study, eyes with a minimum 12month follow-up were reexamined. The RPCP VD and RNFL thickness in the rhegmatogenous retinal detachment subfields of the affected eye (study group) were compared with the corresponding areas of the healthy fellow eyes (control group).Results: Fifty-three eyes were included in the study. A significantly lower RPCP VD and RNFL thickness were observed in those subfields affected by rhegmatogenous retinal detachment compared with those of the control group (P , 0.001). No statistically significant differences were observed between undetached subfields in the study group and their corresponding images in the control group. In the study group, a significant correlation was found between RPCP VD and RNFL thickness in subfields with detached retina (r = 0.393, P , 0.001) and undetached retina (r = 0.321, P , 0.001).Conclusion: Radial peripapillary capillary plexus VD changes were found in the subfields of detached retina successfully treated with pars plana vitrectomy and they correlated with RNFL thinning. These data suggest a coexistence of neuronal and microvascular damage in patients affected by rhegmatogenous retinal detachment.

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Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography Evaluation of Peripapillary Microvascular Changes After Rhegmatogenous Retinal Detachment Repair

Bonfiglio

Ortisi

Nebbioso³

et al. 2021

Retina

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show abstract

“…Previous studies found that averaging OCTA images could improve vessel clarity that might enhance accurate acquisition of OCTA metrics. 13,25 Uji et al 26 reported that averaging three OCTA frames resulted in signi cant improvement, while averaging ve frames could result in almost identical ndings. Clinically, automated averaging of several OCTA metrics for an overall result is not available from any proprietary software.…”

Section: Discussionmentioning

confidence: 99%

“…Most built-in auto-focus systems are limited to correct spherical defocus. Jung et al 13 found that vessel length density (VD) could be reduced by 0.5mm −1 per diopter of induced with-the-rule astigmatism.…”

Section: Introductionmentioning

confidence: 99%

Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Lam

Lau

Wong

et al. 2021

Preprint

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ObjectiveTo compare fixation deviation and stability with soft contact lens correction and device built-in auto-focus system during optical coherence tomography angiography (OCTA).MethodsThis observational study measured OCTA metrics first with contact lens correction, followed by removal of contact lenses, using the device auto-focus system at a University Optometry Clinic, Hong Kong. All participants were habitual soft contact lens wearers with either low or high myopia. OCTA measurements were obtained using a spectral domain OCTA. Fixation deviation was distance (in pixels) of the fovea to the center of the OCTA measurement grid. Fixation stability was test-retest repeatability (TRR) and coefficient of variation (CV) of fixation deviation from three consecutive OCTA measurements. OCTA metrics included vessel length density (VD), perfusion density (PD), and foveal avascular zone (FAZ) area. Averaged OCTA metrics were calculated from three measurements and compared between the two correction methods.ResultsThe mean ± SD spherical equivalent of 74 eyes from 74 myopes measured was -1.94D ± 0.75D in low myopes (n=37) and -7.97D ± 1.31D in high myopes (n=37). When corrected with contact lenses, visual acuities of high myopes (median [IQR], -0.06 [0.08] logMAR) and low myopes (0.02 ± 0.08 logMAR) were similar (P = 0.060), and with similar fixation deviation (5.0 ± 2.2 pixels vs 5.3 [3.6] pixels; P = 0.689). High myopes had poorer fixation stability than low myopes (TRR: 10.2 pixels vs 7.5 pixels; CV: 65% vs 54%, respectively). The worst fixation stability occurred when high myopes were corrected using the auto-focus system (TRR: 12.5 pixels, CV: 72%). The difference in VD and PD was within 1mm-1 and 1%, respectively. The FAZ area was similar.Conclusions High myopes had more stable fixation when corrected when wearing contact lenses. Subjects with good contact lens corrected visual acuity should wear their contact lenses during OCTA measurements.

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“…This could be due to the protocol using an average from three OCTA measurements. Previous studies found that averaging OCTA images could improve vessel clarity that might enhance accurate acquisition of OCTA metrics 13 , 25 . Uji et al 26 reported that averaging three OCTA frames resulted in significant improvement, while averaging five frames could result in almost identical findings.…”

Section: Discussionmentioning

confidence: 99%

“…Most built-in auto-focus systems are limited to correct spherical defocus. Jung et al 13 found that vessel length density (VD) could be reduced by 0.5 mm −1 per diopter of induced with-the-rule astigmatism.…”

Section: Introductionmentioning

confidence: 99%

Fixation stability and deviation in optical coherence tomography angiography using soft contact lens correction in myopes

Lam

Lau

Wong

et al. 2021

Sci Rep

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To compare fixation deviation and stability with soft contact lens correction and device built-in auto-focus system during optical coherence tomography angiography (OCTA). This observational study measured OCTA metrics first with contact lens correction, followed by removal of contact lenses, using the device auto-focus system at a University Optometry Clinic, Hong Kong. All participants were habitual soft contact lens wearers with either low or high myopia. OCTA measurements were obtained using a spectral domain OCTA. Fixation deviation was distance (in pixels) of the fovea to the center of the OCTA measurement grid. Fixation stability was test–retest repeatability (TRR) and coefficient of variation (CV) of fixation deviation from three consecutive OCTA measurements. OCTA metrics included vessel length density (VD), perfusion density (PD), and foveal avascular zone (FAZ) area. Averaged OCTA metrics were calculated from three measurements and compared between the two correction methods. The mean ± SD spherical equivalent of 74 eyes from 74 myopes measured was − 1.94D ± 0.75D in low myopes (n = 37) and − 7.97D ± 1.31D in high myopes (n = 37). When corrected with contact lenses, visual acuities of high myopes (median [IQR], − 0.06 [0.08] logMAR) and low myopes (− 0.02 ± 0.08 logMAR) were similar (P = 0.060), and with similar fixation deviation (5.0 ± 2.2 pixels vs 5.3 [3.6] pixels; P = 0.689). High myopes had poorer fixation stability than low myopes (TRR: 10.2 pixels vs 7.5 pixels; CV: 65% vs 54%, respectively). The worst fixation stability occurred when high myopes were corrected using the auto-focus system (TRR: 12.5 pixels, CV: 72%). The difference in VD and PD was within 1 mm−1 and 1%, respectively. The FAZ area was similar. Difference in OCTA metrics was small in each refractive group (< 1 mm−1 in VD, and < 2% in PD). High myopes had more stable fixation when corrected when wearing contact lenses. Subjects with good contact lens corrected visual acuity should wear their contact lenses during OCTA measurements.

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Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics

Cited by 12 publications

References 50 publications

Optical Coherence Tomography Angiography Evaluation of Peripapillary Microvascular Changes After Rhegmatogenous Retinal Detachment Repair

Optical Coherence Tomography Angiography Evaluation of Peripapillary Microvascular Changes After Rhegmatogenous Retinal Detachment Repair

Fixation Stability and Deviation in Optical Coherence Tomography Angiography Using Soft Contact Lens Correction in Myopes

Fixation stability and deviation in optical coherence tomography angiography using soft contact lens correction in myopes

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