Effects of Induction of Parturition in Ewes with Dexamethasone or Oestrogen on Concentrations of Immunoglobulins in Colostrum, and Absorption of Immunoglobulins by Lambs

Dawe, Sharon; Husband, A J; Langford, Cheryl

doi:10.1071/bi9820223

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…Comparison of the colostral IgG levels among the groups showed significant differences between GR II and GR III at 48 hours, which was not clinically important. In contrast to the results of the present study, some researchers (11,15) have determined that IP reduces the colostral IgG levels. At parturition, the colostral IgG level was highest in GR IV, but the increase was not significant.…”

Section: Discussioncontrasting

confidence: 99%

“…Hormonal alterations following IP may negatively affect the colostral IgG level (10,11,23). IP with 10, 17.5 and 25 mg doses of dexamethasone at the 142nd-145th days of gestation causes a decrease in the colostral IgG levels in ewes (15). In goats, IP with a PGF 2α analog resulted in higher colostral IgG levels in the control group than in the induced group, because prolactin reached its peak level 24 hours before parturition, stimulated lactogenesis and terminated the transfer of IgG to mammary secretions (11).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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SummaryObjective: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. Materials and methods: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA. Results: A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II. Conclusion and clinical relevance: Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for IP.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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“…hormones (Dawe, Husband, & Langford, 1982;Green, Hunter, & Mann, 2005). The oestrogen receptor (ER), androgen receptor (AR) and progesterone nuclear receptor (PGR) are all members of the nuclear receptor family (Patel et al, 2015;Tsai & O'Malley, 1994).…”

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confidence: 99%

Expression of oestrogen receptor, androgen receptor and progesterone nuclear receptor in sheep uterus during the oestrous cycle

Duan

Xiao

et al. 2019

Reprod Domestic Animals

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Oestrogen, androgen and progesterone are involved in the regulation of uterine physiological functions, with the participation of the following proteins: oestrogen receptor (ER), androgen receptor (AR) and progesterone nuclear receptor (PGR). In this study, we used immunohistochemistry to detect the localization of ERα, ERβ, AR and PGR in sheep uterus. Additionally, we used real‐time polymerase chain reaction (RT‐qPCR) and Western blot technique to analyse their expression profiles at different stages of sheep oestrous cycle in the endometrium and myometrium. Immunohistochemical analysis showed that ERα, ERβ, AR and PGR were present in sheep uterus in oestrus, mainly in the uterine luminal epithelium, stroma, gland and myometrium. Real‐time polymerase chain reaction results showed that in the endometrium, ERα expression level was highest in oestrus. ERβ and PGR, instead, were highly expressed in pro‐oestrus. In the myometrium, ERα was highly expressed in both oestrus and pro‐oestrus, and ERβ was highly expressed in oestrus and dioestrus. Progesterone nuclear receptor expression was highest in oestrus, followed by metoestrus. In the endometrium, both receptors ERα and ERβ were abundant in pro‐oestrus, while the maximum AR protein content was found in oestrus. At this stage of the oestrous cycle, PGR protein concentration in the myometrium was significantly lower than those observed in other stages. These results suggest that these receptors are important for sheep reproductive function, as their expression at mRNA and protein levels exhibits particular time‐ and tissue‐specific profiles along the oestrous cycle.

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“…In addition to endogenous hormones, exogenous hormones can also affect colostrum yield and composition (Dawe et al, 1982;Field et al, 1989). It has been reported that sows chemically induced to farrow trended toward the production of less colostrum and that the colostrum contained less fat (Farmer and Quesnel, 2009;Jackson et al, 1995;Milon et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Quantifying the effect of lactogenic antibody on porcine epidemic diarrhea virus infection in neonatal piglets

Poonsuk

Zhang

Chen

et al. 2016

Veterinary Microbiology

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The contribution of lactogenic antibody to the protection of piglets against porcine epidemic diarrhea virus (PEDV) was evaluated. Pregnant multiparous sows and their litters were allocated to one of 3 treatment groups: Group 1-6 serum antibody-negative sows and a subset (n=11) of their piglets. Group 2-8 serum antibody-positive sows and their 91 piglets. Piglets were orally inoculated with PEDV at 4 (Group 1) or 2 (Group 2) days of age. Group 3-2 PEDV serum antibody-negative sows and 22 piglets, provided a baseline for piglet survivability and growth rate. Piglets were monitored daily for clinical signs, body weight, and body temperature through day post-inoculation (DPI) 12 (Groups 2 and 3) or 14 (Group 1). Serum and mammary secretions were tested for PEDV IgG, IgA, and virus-neutralizing antibody. Feces were tested by PEDV real-time, reverse transcriptase PCR (rRT-PCR). Piglets on sows without (Group 1) or with (Group 2) anti-PEDV antibody showed significantly different responses to PEDV infection in virus shedding (p<0.05), thermoregulation (p<0.05), growth rate (p<0.05), and survivability (p<0.0001). Specifically, Group 1 piglets shed more virus on DPIs 1 to 5, were hypothermic at all sampling points except DPIs 9, 11, and 12, gained weight more slowly, and exhibited lower survivability than Group 2 piglets. Within Group 2 litters, significant differences were found in virus shedding (p<0.05), and body temperature (p<0.05), but not in piglet survival rate. The number of sows and litters in Group 2 was insufficient to derive the relationship between specific levels of lactogenic antibody (FFN, IgA, and IgG) and the amelioration of clinical effects. However, when combined with previous PEDV literature, it can be concluded that the optimal protection to piglets will be provided by dams able to deliver sufficient lactogenic immunity, both humoral and cellular, to their offspring.

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Effects of Induction of Parturition in Ewes with Dexamethasone or Oestrogen on Concentrations of Immunoglobulins in Colostrum, and Absorption of Immunoglobulins by Lambs

Cited by 13 publications

References 16 publications

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Expression of oestrogen receptor, androgen receptor and progesterone nuclear receptor in sheep uterus during the oestrous cycle

Quantifying the effect of lactogenic antibody on porcine epidemic diarrhea virus infection in neonatal piglets

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