Effects of Infectious Bursal Disease Vaccination Strains on the Immune System in Leghorn Chickens

Kulikova, L. N.; Jurajda, V.; Juranová, R.

doi:10.2754/avb200473020205

Cited by 8 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The result demonstrated highly significant size decreasing in the control group, as compared with the treatment (P < 0.01) ( Table 3). This can occur due to microscopic lesions and atrophy of the BF caused by IBDV D78 (Al-Mufarrej, 2013;Hedayati et al, 2005;Kulikova et al, 2004;Yao et al, 1998). The antibody titer against IBDV was observed in the control group, but not in the treatment group (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces

et al. 2015

View full text Add to dashboard Cite

“…The reduction in antibody responses may be due to depletion of lymphocytes by the live IBD viruses used as vaccine. Kulikova et al (2004) had already reported that chicks vaccinated with milder vaccines (milder stimulation) had higher antibody titres than those vaccinated with vaccines of more pathogenic strains. That report shows that, the more pathogenic ("hot") IBD vaccines deplete more lymphocytes (the immune cells) than the milder vaccines while present finding suggests that higher units of IBD virus in the vaccine also lead to depletion of more lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from stimulating production of antibodies, IBD virus causes destruction of the bursa of Fabricius (Muller et al, 1979). So, overstimulation of the bursa by live IBD vaccines can lead to depletion of the Blymphocytes and destruction of bursa of Fabricius which will then cause reduction in level of immune responses of chicks to IBD vaccination and to vaccinations against other diseases (Kulikova et al, 2004). The fact that the control group had the least bursa-weight/body-weight ratio and negligible antibody titre supports the observation by Kulikova et al (2004) that IBD-vaccinated chicks which had statistically insignificant BF index produced the lowest average post vaccination antibody titres.…”

Section: Discussionmentioning

confidence: 99%

Immune stimulation and antibody response of chicks to different doses/units of the Nigerian live infectious bursa disease vaccine

2021

JoSVAS

View full text Add to dashboard Cite

Vaccination failure is one of the major constraints to disease control in poultry. To investigate Infectious bursa disease (IBD)-vaccination failures (frequently/globally reported), batches of the Nigerian live-vaccine were tested for viral units before vaccinating following chick-groups: 16 doses (65,536 units), 8 doses (32,768 units), 4 doses (6,384 units), 2 doses (8,192 units), 1 dose (4,096 units), 1:2 dose (2,048 units), 1:4 dose (1,024 units), 1:8 dose (512 units), 1:16 dose (256 units) and control. Each batch gave 4,096 viral units. Mean bursa weight/body weight ratios (immune stimulation) and mean antibody titres of the chick-groups were 47.40 ±5.45 and 51.20 ±7.83; 44.25 ±7.28 & 48.00 ±9.24; 45.25 ± 4.28 and 64.00 ± 0.00; 43.00 ±7.58 and 101.60 ± 35.05; 44.60 ± 5.51 and 128.00 ± 0.00; 42.60 ± 6.23 and 268.80 ± 16.00; 40.50 ± 1.76 and 80.00 ±16.00; 31.40 ± 3.80 and 80.00 ± 27.71; 37.18 ± 4.07 and 89.60 ± 15.68 and 26.20 ± 3.31 and 19.20 ± 5.99, respectively. Half (2,048 units) of the recommended 1-dose gave optimal antibody-titre. The higher doses gave lower antibody-titres like the lower doses but immune stimulation continued to increase as doses/units increased. Both over-stimulating the immune system (too high vaccine-doses/viral-units/viral-virulence) and under-stimulation cause vaccination failure.

show abstract

“…Therefore, the disease has a significant economic impact on all areas of intensive poultry farms (2,8). From the early 1970s, numerous IBD vaccines and vaccination programs have been studied for prevention and control of IBD (9). It has been suggested that, vaccine should be prepared only from strains of virus which are of attenuated virulence or from naturally occurring strains of low virulence (10).…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Standardization of New Infectious Bursal Disease Virus for Development of a Live Vaccine

et al. 2013

View full text Add to dashboard Cite

Background and Aims: Infectious bursal disease (IBD) is an acute contagious viral disease of birds worldwide. The causative virus induces a persistent immune suppression following destroy B lymphocytes precursors in bursal lymphoid follicles. Vaccination is the main strategy for prevention of the disease in commercial poultry industry. Materials and Methods:To produce a live vaccine against the disease, an new virus strain was isolated from the affected bursa of Fabricius. Diagnostic serological tests, histopathology and molecular examinations were done for pathotyping the isolate. Results:The results indicated that the virus is a new strain and named IBD07IR. In case of developing live IBD vaccine, the bacteriology, purity, titration, reversion to virulence, bursabody index, immunosupression and efficacy tests were performed on the candidate vaccine virus seed. The live vaccine was produced following propagation of the IBDV seed in SPF embryonated eggs. The proper dose of the vaccine was found by administration of SPF chicken groups. Afterward, the laboratory trial was scaled and the clinical trials were done three times with different administration routs. Conclusion: According to serological assays and challenge, the developed live IBD vaccine induces an adequate immunity in both SPF and commercial chickens and had no adverse effects.

show abstract

Effects of Infectious Bursal Disease Vaccination Strains on the Immune System in Leghorn Chickens

Cited by 8 publications

References 12 publications

Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces

Inhibition of infectious bursal disease virus transmission using bioceramic derived from chicken feces

Immune stimulation and antibody response of chicks to different doses/units of the Nigerian live infectious bursa disease vaccine

Isolation, Characterization and Standardization of New Infectious Bursal Disease Virus for Development of a Live Vaccine

Contact Info

Product

Resources

About