Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

Juhn, Steven K.; Jung, Timothy T. K.; Lin, Jizhen; Rhee, Choong Kyun

doi:10.1111/j.1749-6632.1997.tb51885.x

Cited by 44 publications

(39 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4][5][6] It is generally believed that the passage of inflammatory mediators through the round window membrane into the scala tympani induced inner ear damage and SNHL. [7,8] MacArthur et al [9] suggested another point of view, that the inner ear could manifest a direct inflammatory response to COM resulting in SNHL. They demonstrated the capability of cochlear tissues to express cytokine mRNA that contributes to the inflammation and remodeling, occurring in association with middle ear disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of inner ear changes as result of chronic otitis media and its surgery

Külekçi²,

Naiboğlu³

et al. 2015

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

Objectives: This study aims to evaluate whether chronic otitis media (COM) may cause inner ear damages or middle ear surgery may improve this damage with regard to sensorineural hearing loss (SNHL) and tinnitus and dizziness-related disability. Patients and Methods:An observational prospective study was performed on a series of 65 patients (41 males, 24 females; mean age 26.4±12.6; range 11 to 62 years) who were diagnosed with COM and were scheduled for surgical intervention at the Department of Otorhinolaryngology of the Haydarpasa Numune Education and Research Hospital. Patients were divided into two subgroups as tympanoplasty and mastoidectomy group according to the surgical procedure. Standard patient work-up included otomicroscopy, pure tone audiometry and completion of the Turkish translation of Dizziness Handicap Inventory (DHI) and Tinnitus Handicap Inventory (THI) before surgery and eight weeks after surgery. Results:We found higher bone conduction thresholds in the group of patients with mastoidectomy preoperatively. There was a statistically significant difference in the mean preoperative and postoperative THI and DHI scores between the groups (p<0.05). Conclusion:Our study results suggest that a successful surgery results in improved tinnitus and vertigo symptoms in patients with COM.Keywords: Chronic otitis media; tinnitus; vertigo. ÖZ Amaç:Bu çalışmada kronik otitis media (KOM)'nın iç kulak hasarına yol açıp açmadığı veya sensörinöral işitme kaybı, tinnitus ve baş dönmesi açısından, bu hasarın orta kulak cerrahisi ile düzelip düzelmediği değerlendirildi. Hastalar ve Yöntemler:Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Kulak Burun Boğaz Kliniği'nde KOM tanısı konulan ve cerrahi planlanan 65 hasta (41 erkek, 24 kadın; ort. yaş 26.4±12.6 yıl; dağılım 11-62 yıl) serili gözlemsel prospektif bir çalışma yapıldı. Hastalar cerrahi işleme göre timpanoplasti ve mastoidektomi grubu olarak iki alt gruba ayrıldı. Standart hasta değerlendirmesi cerrahi öncesi ve cerrahiden sekiz hafta sonra uygulanan otomikroskopi, saf ses odyometrisi, Baş Dönmesi Engellilik Envanteri (DHI) ve Tinnitus Engellilik Anketinin (THI) tamamlanmasını içerdi. Bulgular:Mastoidektomili hasta grubunda ameliyat öncesi kemik yolu işitme eşikleri daha yüksek bulundu. Ameliyat öncesi ve ameliyat sonrası THI ve DHI skorları açısından gruplar arasında istatistiksel olarak anlamlı bir fark görüldü (p<0.05).Sonuç: Çalışma sonuçlarımız, KOM hastalarının tinnitus ve vertigo semptomlarının başarılı bir cerrahi ile iyileşebileceğini göstermektedir.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of inner ear changes as result of chronic otitis media and its surgery

Külekçi²,

Naiboğlu³

et al. 2015

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

show abstract

“…Most middle ear inflammatory mediators and toxins from the middle ear enter the inner ear through the round window membrane [1]. Deafness results from the spread of infection to the labyrinth and consequent endorgan damage.…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase inhibitor attenuates cochlear lateral wall damage induced by intratympanic instillation of endotoxin

Choi

Jang

Cho

et al. 2012

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

“…However, inner ear dysfunction secondary to chronic OM, including high-frequency sensorineural hearing loss or vertigo, is not uncommon (13,26,36,55,60). Although chronic middle ear inflammation is believed to cause inner ear dysfunction by entry of OM pathogen components or cytokines from the middle ear into the inner ear, the underlying mechanisms are not well understood (18,32,39,44,52,87).…”

mentioning

confidence: 99%

Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae -Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear

et al. 2007

View full text Add to dashboard Cite

Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineural hearing loss or vertigo, is not uncommon. Although chronic middle ear inflammation is believed to cause inner ear dysfunction by entry of OM pathogen components or cytokines from the middle ear into the inner ear, the underlying mechanisms are not well understood. Previously, we demonstrated that the spiral ligament fibrocyte (SLF) cell line up-regulates monocyte chemotactic protein 1 (MCP-1) expression after treatment with nontypeable Haemophilus influenzae (NTHI), one of the most common OM pathogens. We hypothesized that the SLF-derived MCP-1 plays a role in inner ear inflammation secondary to OM that is responsible for hearing loss and dizziness. Antibiotics have led to a dramatic decline in the incidence of life-threatening complications of otitis media (OM), such as meningitis or brain abscess (3). However, inner ear dysfunction secondary to chronic OM, including high-frequency sensorineural hearing loss or vertigo, is not uncommon (13,26,36,55,60). Although chronic middle ear inflammation is believed to cause inner ear dysfunction by entry of OM pathogen components or cytokines from the middle ear into the inner ear, the underlying mechanisms are not well understood (18,32,39,44,52,87).The inner ear is a sensory organ for hearing (cochlea) and equilibrium (vestibule). It consists of a variety of specialized cell types (50, 51), such as sensory hair cells, supporting cells, sulcus cells, and spiral ligament fibrocytes (SLFs), which are the most abundant cell types exposed to the perilymph. The type of inner ear cells that respond to proinflammatory signals entering the inner ear remain unknown. Considering that SLFs are one of the abundant cell types in the cochlea and that they secrete cytokines and chemokines after proinflammatory stimuli (72, 97), we hypothesized that the SLFs are major responders to such signals.Preliminary studies of human temporal bones with labyrinthitis showed the infiltration of lysozyme-positive round cells with a monomorphic nucleus into the spiral ligament (unpublished data). Also, SLF cell lines (96) showed an induction in monocyte chemotactic protein 1 (MCP-1) expression after treatment with lysate of nontypeable Haemophilus influenzae (NTHI), one of the most common OM pathogens (72). Moreover, it has previously been shown that monocytes can infiltrate cochlea exhibiting chronic middle ear inflammation or acoustic trauma (22,34,37). These results led us to focus on MCP-1 as an SLF-derived proinflammatory chemokine attracting effector cells and causing inner ear dysfunction.MCP-1, also known as the chemokine C-C motif ligand 2, is produced by various cells, including endothelial cells, smooth muscle cells, fibroblasts, and macrophages, in response to cytokines, growth factors, or bacterial components (9,46,78). It is encoded by an immediate-early gene (33) and is up-regulated by various stimuli such as bacterial lipopolysaccharide (LPS), interleukin-1 (IL-1), tumor necrosis fact...

show abstract

Effects of Inflammatory Mediators on Middle Ear Pathology and on Inner Ear Function

Cited by 44 publications

References 39 publications

Clinical evaluation of inner ear changes as result of chronic otitis media and its surgery

Clinical evaluation of inner ear changes as result of chronic otitis media and its surgery

Matrix metalloproteinase inhibitor attenuates cochlear lateral wall damage induced by intratympanic instillation of endotoxin

Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae -Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear

Contact Info

Product

Resources

About