Effects of inhaled fluticasone propionate on CTLA‐4‐positive CD4+CD25+ cells in induced sputum in mild asthmatics

Abstract

The percentage of airway CTLA-4+CD4+CD25+ cells increased after FP treatment, coincident with improvements in airway inflammation and hyperresponsiveness.Whether improved asthma assessments are related to the increase in CTLA-4+CD4+CD25+ cells and thus improved regulation of T-cell tolerance and differentiation will require a larger sample size to determine. The normalization of CTLA-4+CD4+CD25+ cells in asthma may contribute to the management of this disease.

Respirology year‐in‐review 2008: Basic science

“…The effect of inhaled steroids on these suppressor cells was tested in a 14-day, placebo controlled trial of 11 mild asthmatics given inhaled fluticasone. 17 Fluticasone increased the number of CTLA-4+CD4+CD25+ cells in sputum. While bronchial hyper-responsiveness and sputum eosinophilia also improved with fluticasone, these improvements did not correlate with the increase in CTLA-4+CD4+CD25+ cells.…”

“…Cytotoxic T‐lymphocyte antigen (CTLA)‐4 is a marker of activated T cells. The effect of inhaled steroids on these suppressor cells was tested in a 14‐day, placebo controlled trial of 11 mild asthmatics given inhaled fluticasone 17 . Fluticasone increased the number of CTLA‐4+CD4+CD25+ cells in sputum.…”

Role of Regulatory T cells in Airway Inflammation in Asthma

“…A randomized double-blind, cross-over, placebo control trial investigated whether treatment with ICS (Fluticasone propionate, GSK, Japan) could increase the population of sputum CTLA4 + Tregs, decrease sputum eosinophils, and increase interleukin (IL)-10 ( Figure 6) [41]. The effect of ICS on Foxp3 + Tregs has not yet been investigated in patients with asthma.…”

“…* p<0.05 versus pre-treatment. B) Comparison of changes in IL-10, TGF-β1 and IL-13 levels of sputum supernatants between ICS and placebo [41]. Data were expressed as mean (SEM).…”

Elevated circulating cytotoxic T lymphocyte‐associated antigen‐4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease

“…1,2 Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the immunoglobulin gene superfamily and plays an important role in the downregulation of the T-cell response, T-cell homeostasis and maintenance of peripheral tolerance. 3 However, no data are available concerning the potentially important relationship between COPD and CTLA-4. This study aimed to investigate the relationships between serum levels of soluble CTLA-4 in COPD patients and lung function and inflammation.…”