Effects of inhaled nitric oxide on hemostasis in healthy adults treated with heparin: a randomized, controlled, blinded crossover study

Goldstein, Brahm; Baldassarre, James; Young, Jodi N.

doi:10.1186/1477-9560-10-1

Cited by 11 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They share a common triprenyl isoindolinone core unit. Among them, SMTP-7 (see Figure 1 ) has shown the best fibrinolytic effect [ 7 , 9 ]. Most attractively, it was effective in treating thrombotic stroke in primates [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway

Yin

et al. 2017

Marine Drugs

View full text Add to dashboard Cite

Many fungi in the Stachybotrys genus can produce various isoindolinone derivatives. These compounds are formed by a spontaneous reaction between a phthalic aldehyde precursor and an ammonium ion or amino compounds. In this study, we suggested the isoindolinone biosynthetic gene cluster in Stachybotrys by genome mining based on three reported core genes. Remarkably, there is an additional nitrate reductase (NR) gene copy in the proposed cluster. NR is the rate-limiting enzyme of nitrate reduction. Accordingly, this cluster was speculated to play a role in the balance of ammonium ion concentration in Stachybotrys. Ammonium ions can be replaced by different amino compounds to create structural diversity in the biosynthetic process of isoindolinone. We tested a rational supply of amino compounds ((±)-3-amino-2-piperidinone, glycine, and l-threonine) in the culture of an isoindolinone high-producing marine fungus, Stachybotrys longispora FG216. As a result, we obtained four new kinds of isoindolinone derivatives (FGFC4–GFC7) by this method. Furthermore, high yields of FGFC4–FGFC7 confirmed the outstanding production capacity of FG216. Among the four new isoindolinone derivatives, FGFC6 and FGFC7 showed promising fibrinolytic activities. The knowledge of biosynthesis pathways may be an important attribute for the discovery of novel bioactive marine natural products.

show abstract

Section: Introductionmentioning

confidence: 99%

Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway

Yin

et al. 2017

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Strokes have also been reported following viper bites presumably due to a similar mechanism [ 12 , 13 ]. There is one case report of a patient who developed ischemic stroke after a hump-nosed viper bite [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction associated with thrombotic microangiopathy following a hump-nosed viper bite: a case report

2017

View full text Add to dashboard Cite

BackgroundHump-nosed viper bite is the commonest cause of venomous snakebite in Sri Lanka. Despite initially being considered a moderately venomous snake more recent reports have revealed that it could cause significant systemic envenoming leading to coagulopathy and acute kidney injury. However, myocardial infarction was not reported except for a single case, which occurred immediately after the snakebite.Case presentationA 50-year-old previously healthy Sri Lankan woman had a hump-nosed viper bite with no evidence of systemic envenoming during initial hospital stay. Five days later she presented with bite site cellulitis with hemorrhagic blisters, acute kidney injury, and evidence of microangiopathic hemolytic anemia and thrombocytopenia with normal coagulation studies. She was managed with supportive care that included intravenously administered antibiotics, blood transfusions, and hemodialysis; both her microangiopathic hemolytic anemia and thrombocytopenia improved without any specific intervention. On day 10 she developed: a non-ST elevation myocardial infarction complicated with acute left ventricular failure evidenced by acute shortness of breath with desaturation despite adequate ultrafiltration; new onset lateral lead T inversions in electrocardiogram; raised troponin I titer; and hypokinetic segments on echocardiogram. She was managed with low molecular weight heparin and antiplatelet drugs, which were later discontinued due to upper gastrointestinal bleeding. Her hospital stay was further complicated by hospital-acquired pneumonia and deep vein thrombosis involving her ileofemoral vein. She died on day 33 from the snakebite.ConclusionsMyocardial infarction after snakebites is rarely reported. This is the first case report of a patient developing a myocardial infarction during the recovery phase of thrombotic microangiopathy following a hump-nosed viper bite. The possibility of thrombotic risk related to thrombotic microangiopathy following hump-nosed viper bite is an area that is poorly studied; it needs further attention.

show abstract

“…Inhaled NO in healthy males did not alter hemostasis significantly, as measured by the activated partial thromboplastin time (aPTT) and the bleeding time [16]. However, inhalation of NO in animals resulted in prolongation of the bleeding time [17], and the inhibition of NO synthesis shortened the prolonged bleeding time in uremic rats [18].…”

Section: No and Pro-coagulant Factorsmentioning

confidence: 97%

Nitric Oxide, Coagulation and Cancer

Derman¹,

Kwaan²,

Elbatarny

et al. 2015

Nitric Oxide and Cancer: Pathogenesis and Therapy

View full text Add to dashboard Cite

Nitric Oxide (NO) is a well-known potent and rapid vasodilator and inhibitor of coagulation. Synthesized from an L-arginine precursor, NO is produced via the Nitric Oxide Synthase enzyme which is expressed constitutively in endothelial cells. Nitric oxide has a wide range of biological properties that maintain vascular homeostasis and protection of the vessel from injurious consequences. The decreased production of NO in pathological states causes deleterious effects, creating an endothelial dysfunction state with a wide variety of subsequent diverse biological effects. There is now evidence of the link between hypoxia and/or reduction of NO availability and coagulopathies. NO is also a modulator of various cancerrelated events and has anti-tumor properties. Cancer is a known hypercoagulable state and hypoxia is a typical feature of the tumor micro-environment. Cancer patients-particularly those with advanced or metastatic states-are at higher risk of developing venous and arterial thromboembolic events. The dichotomous nature of nitric oxide with regard to its tumorigenic and tumoricidal properties are at present under intense investigation. The transcendent field of nanotechnology has moved into the realm of NO donor therapy, though currently there are no commercially available carriers of NO. While nanotechnology is not quite at the translational research stage, it poses the greatest potential for storage and site-specific delivery of high concentrations of NO to tumors. In this chapter, we review the effects of NO on various hemostatic elements, the pro-tumoral and anti-tumoral effects of NO and finally shed some light on the link between NO, cancer and coagulopathies. Keywords

show abstract

Effects of inhaled nitric oxide on hemostasis in healthy adults treated with heparin: a randomized, controlled, blinded crossover study

Cited by 11 publications

References 23 publications

Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway

Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway

Acute myocardial infarction associated with thrombotic microangiopathy following a hump-nosed viper bite: a case report

Nitric Oxide, Coagulation and Cancer

Contact Info

Product

Resources

About