Effects of Inhaled Nitric Oxide and Prostaglandin E1 on Hemodynamics and Arterial Oxygenation in Patients Following Single Lung Transplantation

Triantafillou, A. N.; Pohl, Mary S.; Okayabashi, K.; Cooper, Joel D.; Patterson, G.A.; Lappas, Demetrios G.

doi:10.1213/00000539-199504001-00039

Cited by 6 publications

(1 citation statement)

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“…Recently, in an experimental model on lung ischaemia-reperfusion injury (rats), it is reported that iNO shows to be toxic in reperfusion, but proteetive at 4 hours of reperfusion (11). Alierial oxygenation improved and mPA decreased in single lung transplantation recipient patients during early postoperative iNO (33). Even though the effects of iNO on pulmonary circulation are weil demonstrated, its effects on the respiratory system mechanics and gas exchange remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Inhaled Nitric Oxide in Patients with Cystic Fibrosis During Preoperative Evaluation and During Anaesthesia for Lung Transplantation

Rocca¹,

Coccia²,

Pugliese³

et al. 1998

Eur J Pediatr Surg

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In the preoperative evaluation a significant decrease of mean pulmonary artery pressure, pulmonary vascular resistance index and intrapulmonary shunt, with an increase of PaO2/FiO2, were observed during iNO administration, compared to baseline in 100% O2. During lung transplantation a significant decrease in intrapulmonary shunt was noted. All the transplants were successfully performed without cardio-pulmonary bypass. In all procedures, after iNO administration, we observed no modification of systemic haemodynamics. In conclusion, our study confirms the pulmonary effects of iNO without any systemic effects in patients affected by cystic fibrosis during preoperative evaluation and during anaesthesia for lung transplantation.

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Section: Discussionmentioning

confidence: 99%

Inhaled Nitric Oxide in Patients with Cystic Fibrosis During Preoperative Evaluation and During Anaesthesia for Lung Transplantation

Rocca¹,

Coccia²,

Pugliese³

et al. 1998

Eur J Pediatr Surg

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Challenge in Perioperative Care Transplantation: Lung Transplant

Rocca¹,

Coccia²,

Pietropaoli³

2001

Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Perioperative anaesthetic considerations for patients undergoing lung transplantation

Singh

Bossard

1997

Can J Anaesth

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Purpose: Five thousand, two hundred and eight lung transplants were performed worldwide before April, 1996. This review will discuss lung transplantation from an historical perspective, its indications, donor and recipient selection criteria, donor lung preparation, su~cal considerations, perioperative anaesthetic management, and associated morbidity and mortality. Source: Recent literature on perioperative anaesthetic management of lung transplantation and experience from international centres including the Toronto Lung Transplant Group and the St. Louis Lung Transplant Group. Principal fiadings: Lung transplantation comprises of a family of operations, including single lung transplant, bilateral single lung transplant, lobar transplant and block heart-lung transplant. Improved donor lung preservation techniques have increased the duration of cold ischaemic time. The advent of bilateral single lung transplant has decreased the requirement for cardiopulmonary bypass, and airway complications have been reduced by adoption of~e telescoping bronchial anastomoses. Advances in perioperative monitoring (including transoesophgeai echocardiography), pulmonary vasodilators (e.g., nitric oxide and prostaglandin El), carcliopulmonary bypass and ventilatory management, and a better understanding of the pathophysiological processes during the procedure have improved perioperative anaesthetic management. Also, advances in broad spectrum antibiotics and immunosuppressant drugs have improved the outcome by better management of the complications of infection and rejection. Conclusion: Lung transplantation improves the quality of life with marginal improvement in life expectancy of the recipients. It is an expensive procedure requiring continued resources for long term management of these patients.Objectif : jusqu'en avril 1996, cinq mille, deux cent huit transplantations de poumons avaient dEj,~ Et~ effectuL~,s ,~ travers le monde. Ce survol permettra de discuter de la transpl@~tion pulmonalre darts sa perspective historique, ses indications, les crit&es de s~lection du receveur et du donneur, la preparation du poumon du donneur, les consid&ations chirurgicales, la gestion p&iol~ratoire de ranesth~sie et la mortaiit~ et la morbidit~ assod~es. Source : Les publications r&entes traitant de la gestion p&iop&atoire de la transplantation pulmonaire et de l'exl:~rience acquise par des centres intemationaux dont le Toronto Lung Transplant Group et le St.Louis Lung Transplant Group. Princlpales r: la transplantation pulmonaire englobe une famille d'interventions dont la transplantation unipulmonaire, bilat&ale simple, Iobaire et coeur-poumons en bloc. I:am61ioration des techniques de pr6servation des poumons du donneur a permis ram~lioration de la durEe de risch6mie froide. I'av~nement de la transplantation bilat~rale simple a rEduit la n~cessitE de la circulation extracorporelle et rintroduction des anastomoses t~lescopiques a permis de r~duire les complications particuli&es aux voles a~dennes. Le perfectionnement du monitorage p~nop&a...

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Effects of Inhaled Nitric Oxide and Prostaglandin E1 on Hemodynamics and Arterial Oxygenation in Patients Following Single Lung Transplantation

Cited by 6 publications

References 0 publications

Inhaled Nitric Oxide in Patients with Cystic Fibrosis During Preoperative Evaluation and During Anaesthesia for Lung Transplantation

Inhaled Nitric Oxide in Patients with Cystic Fibrosis During Preoperative Evaluation and During Anaesthesia for Lung Transplantation

Challenge in Perioperative Care Transplantation: Lung Transplant

Perioperative anaesthetic considerations for patients undergoing lung transplantation

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