Effects of inhaled particulate matter on the central nervous system in mice

Kim, So Young; Kim, Jin Ki; Park, So Hyeon; Kim, Byeong Gon; Oh, Seung Ha; Lee, Jun Ho; Suh, Myung‐Whan; Park, Moo Kyun

doi:10.1016/j.neuro.2018.06.001

Cited by 36 publications

(25 citation statements)

References 33 publications

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“…The researchers identified inflammation in the brains of the dogs along with endothelial damage, which prompted the hypothesis that the initial inflammatory source was the respiratory tract [104]. There is now evidence from several in vivo studies that PM can stimulate inflammatory and oxidative responses in the CNS [104,105,106,107,108,109,110]. Furthermore, Hullmann et al [111] demonstrated that diesel exhaust particles accelerated the development of hallmarks of Alzheimer’s Disease in a mouse disease model.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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It has been hypothesised that environmental air pollution, especially airborne particles, is a risk factor for type 2 diabetes mellitus (T2DM) and neurodegenerative conditions. However, epidemiological evidence is inconsistent and has not been previously evaluated as part of a systematic review. Our objectives were to carry out a systematic review of the epidemiological evidence on the association between long-term exposure to ambient air pollution and T2DM and neurodegenerative diseases in adults and to identify if workplace exposures to particles are associated with an increased risk of T2DM and neurodegenerative diseases. Assessment of the quality of the evidence was carried out using the GRADE system, which considers the quality of the studies, consistency, directness, effect size, and publication bias. Available evidence indicates a consistent positive association between ambient air pollution and both T2DM and neurodegeneration risk, such as dementia and a general decline in cognition. However, corresponding evidence for workplace exposures are lacking. Further research is required to identify the link and mechanisms associated with particulate exposure and disease pathogenesis and to investigate the risks in occupational populations. Additional steps are needed to reduce air pollution levels and possibly also in the workplace environment to decrease the incidence of T2DM and cognitive decline.

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Section: Discussionmentioning

confidence: 99%

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Dimakakou

Johnston

Streftaris

et al. 2018

IJERPH

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“…Immediately after the 3 days of noise exposure, hearing thresholds in all rats were measured by recording auditory brainstem responses (ABRs) (SmartEP; Intelligent Hearing System, Miami, FL, USA) as previously described [ 12 , 13 ] (Fig. 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…RNA was extracted from the hippocampal tissues using TRI reagent® (Sigma-Aldrich, St. Louis, MO, USA) [ 12 , 13 ]. Two hippocampal tissue samples were pooled as a single sample for the total transcript array analysis to increase the quantity of the extracted RNA.…”

Section: Methodsmentioning

confidence: 99%

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Effect of acute noise trauma on the gene expression profile of the hippocampus

et al. 2020

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Background This study aimed to investigate the changes in the expression of hippocampal genes upon acute noise exposure. Methods Three-week-old Sprague–Dawley rats were assigned to control (n = 15) and noise (n = 15) groups. White noise (2–20 kHz, 115 dB sound pressure level [SPL]) was delivered for 4 h per day for 3 days to the noise group. All rats were sacrificed on the last day of noise exposure, and gene expression in the hippocampus was analyzed using a microarray. Pathway analyses were conducted for genes that showed differential expression ≥ 1.5-fold and P ≤ 0.05 compared to the control group. The genes included in the putative pathways were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Results Thirty-eight upregulated genes and 81 downregulated genes were identified. The pathway analyses revealed that upregulated genes were involved in the cellular responses to external stimuli and immune system pathways. qRT-PCR confirmed the upregulation of the involved genes. The downregulated genes were involved in neuronal systems and synapse-related pathways, and qRT-PCR confirmed the downregulation of the involved genes. Conclusions Acute noise exposure upregulated the expression of immune-related genes and downregulated the expression of neurotransmission-related genes in the hippocampus.

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“…Given the increasing epidemiological and toxicological reports relating exposure to fine and ultrafine pollution with impairment of cognitive function [116][117][118][119], one of the primary areas for future toxicological studies should be the understanding of if and how UFP, after interaction with nasal and alveolar epithelial cells, may determine the activation of adverse cellular pathways in neuronal and glial cells [120]. So far the hypotheses are mainly related to the oxidative stress/inflammation paradigm, that will then determine significant damages in cells leading to cell modification and/or to cell death [121,122].…”

Section: Future Perspectivesmentioning

confidence: 99%

Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned

Longhin

Mantecca

Gualtieri

2020

IJMS

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Air pollution is one of the world’s leading environmental causes of death. The epidemiological relationship between outdoor air pollution and the onset of health diseases associated with death is now well established. Relevant toxicological proofs are now dissecting the molecular processes that cause inflammation, reactive species generation, and DNA damage. In addition, new data are pointing out the role of airborne particulates in the modulation of genes and microRNAs potentially involved in the onset of human diseases. In the present review we collect the relevant findings on airborne particulates of one of the biggest hot spots of air pollution in Europe (i.e., the Po Valley), in the largest urban area of this region, Milan. The different aerodynamic fractions are discussed separately with a specific focus on fine and ultrafine particles that are now the main focus of several studies. Results are compared with more recent international findings. Possible future perspectives of research are proposed to create a new discussion among scientists working on the toxicological effects of airborne particles.

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Effects of inhaled particulate matter on the central nervous system in mice

Cited by 36 publications

References 33 publications

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Exposure to Environmental and Occupational Particulate Air Pollution as a Potential Contributor to Neurodegeneration and Diabetes: A Systematic Review of Epidemiological Research

Effect of acute noise trauma on the gene expression profile of the hippocampus

Fifteen Years of Airborne Particulates in Vitro Toxicology in Milano: Lessons and Perspectives Learned

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