Effects of inorganic and organic copper supplemented to first-calf cows on cow reproduction and calf health and performance.

Muehlenbein, Erick; Brink, Dennis R.; Deutscher, Gene H.; Carlson, Michael P.; Johnson, A.B.

doi:10.2527/2001.7971650x

Cited by 62 publications

(70 citation statements)

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“…Based on these results, one could hypothesize that transplacental transfer of Cu, or the ability of the developing foetus to exploit Cu from the mother organism, is partly limited. This is however in contrast with results suggesting that organ Cu concentrations of calves during gestation and early after calving are higher than those of their mothers (Gooneratne and Christensen 1989;Illek and Such˘1993;Muehlenbein et al 2001). The lower blood Cu concentrations of calves compared with their mothers may be due to the fact that in newborn calves ceruroplasmin, the main form of Cu transport in blood, is not produced to a sufficient extent (Roy 1980;Underwood and Suttle 1999).…”

Section: Discussionmentioning

confidence: 73%

“…Despite the fact that according to our results, Cu, compared with Zn, is not cumulated in colostrum to any significant extent, the results pointing to a trend towards correlation between colostral and blood Cu concentration of calves at the end of the period of colostral nutrition suggest that colostrum is an important source of Cu for calves. A prominent upward trend in Cu concentration of calves in the first month after calving has been described by Muehlenbein et al (2001), too.…”

Section: Discussionmentioning

confidence: 88%

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Microelements in Colostrum and Blood of Cows and their Calves during Colostral Nutrition

Pavlata¹,

Pechová²,

Dvořák³

2004

Acta Vet. Brno

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The goal of the study was to use evaluation of blood and colostrum selenium (Se), copper (Cu) and zinc (Zn) concentrations of cows and the same blood concentrations of calves during the period of colostral nutrition to study differences in the metabolism of the different microelements in the mother and its young. Blood was collected from 12 cows and their calves before first intake of colostrum on the calving day and then at the end of the period of colostral nutrition to determine Se, Cu and Zn concentrations. First colostrum was collected from all cows. Se concentration was determined from whole blood and colostrum samples using hydride technique AAS. Cu and Zn concentrations were determined from colostrum and blood serum using flame AAS.The cows under examination were shown to have average concentrations of Se of 0.87 ± 0.30 and 0.47 ± 0.15 µmol·l -1 in whole blood and colostrum respectively, of Cu 8.95 ± 1.95 and 5.37 ± 1.80 µmol·l -1 in blood serum and colostrum respectively, and of Zn 11.62 ± 2.35 and 416.76 ± 120.07 µmol·l -1 in blood serum and colostrum respectively. Blood of calves before the first intake of colostrum was characterized by a significantly higher (p < 0.001) mean concentration of Zn (25.88 ± 8.79 µmol·l -1 ) and a significantly lower (p < 0.001) concentration of Cu (3.23 ± 1.08 µmol·l -1 ) compared with the mothers. Blood Se concentration of the calves (0.91 ± 0.26 µmol·l -1 ) was not significantly different from blood Se concentration of the cows. A significant increase (p < 0.001) in blood Cu concentration of the calves to 7.53 ± 1.98 µmol·l -1 and an insignificant increase in the mean Zn and Se concentrations to 26.40 ± 6.58 µmol·l -1 and 0.93 ± 0.32 µmol·l -1 respectively occurred during colostral nutrition. Correlation analysis showed a significant correlation (p < 0.01) between blood Se concentrations of the mothers and their newborn calves (r = 0.72). No significant correlation was found between Cu and Zn concentrations of cows and their calves. No significant relation between blood and colostrum concentrations of the different microelements of cows was found either.We have shown major differences as to the parameters of the micromineral metabolism under examination at the level of the mother/young relationship. While the calf organism can accumulate Zn throughout the intrauterine development and Zn is cumulated in cow colostrum, too, serum Cu concentrations of newborn calves are significantly lower compared with the mothers and colostrum Cu concentrations reach just about 60% of serum Cu concentrations of the cows. Although blood Cu concentration of calves increases throughout the period of colostral nutrition, it does not reach the level of serum Cu concentration of the mother by the end of the period. The Se status of newborn calves is similar to that of the mother cows and just like with Cu, Se is not cumulated in colostrum to any significant extent.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Microelements in Colostrum and Blood of Cows and their Calves during Colostral Nutrition

Pavlata¹,

Pechová²,

Dvořák³

2004

Acta Vet. Brno

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“…reported that control calves had higher secondary antibody response to pig erythrocytes than copper, molybdenum and iron supplemented calves. Muehlenbein et al (2001) reported that administration of copper had no effect on incidence of neonatal diseases. In the present study, no significant differences were detected in incidence of neonatal diseases and days of treatment due to administration of iron and copper.…”

Section: Discussionmentioning

confidence: 99%

Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

et al. 2008

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The objective of the present study was to examine the effects of parenteral administration of iron and copper on hematological parameters, weight gain, and health of neonatal dairy calves in the period when iron and copper deficiency could be existed. Twenty-four Holstein calves were used for the experiment and randomly assigned to four different treatments. Treatments consisted of (1) control (no injections of Fe and Cu), (2) test 1 (1000 mg Fe as fe-dextran was injected to each calf at day 2 of age), (3) test 2 (160 mg Cu as methionine-copper complex was injected to each calf at day 14 of age), and (4) test 3 (Fe and Cu were injected to each calf as mentioned previously). Blood samples were collected from all of the calves within 24-48 hours after birth and at 7, 14, 21 and 28 days of age for measuring hematological parameters and within 24-48 hours after birth and at 14, 21 and 28 days of age for the determination of iron, copper, TIBC concentrations, and AST activity. Anti-coagulated blood was analyzed shortly after collection for: number of red blood cell (RBC), hemoglobin (Hb), heamatocrit (HCT), total leukocyte count (WBC), Platelet (Plt), MCH, MCV, MCHC, and differential leukocyte counts. The amounts of iron, copper, TIBC, and AST were measured in serum. Group had significant effects on the amounts of HCT, RBC, hemoglobin, MCV, neutrophil, weekly weight gain, and daily gain during each week (p < 0.05). Sampling time had significant effects on the amounts of RBC, MCV, MCH, MCHC, WBC, neutrophil, lymphocyte, monocyte, platelet, fibrinogen, copper, TIBC, AST, weight, weekly gain and, daily gain during each week (p < 0.05). significant interactions between sampling time and group were seen for HCT, RBC, hemoglobin, MCV, platelet, total protein, fibrinogen, iron, and TIBC (p < 0.05). Improved RBC parameters and MCV were seen in calves of group 4 (test 3) in comparing with control group. Total and daily gains were also significantly improved in test groups in comparing with control group (p < 0.05). No significant difference was seen for the days of treatment between groups.

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“…But Zn levels were insufficient for the late pregnancy and early lactation periods. This is probably so because large quantities of Zn are used up by the developing foetus and because high concentrations of Zn are present also in colostrum and milk (Muehlenbein et al, 2001;Kracmar et al, 2003;Pavlata et al, 2004b). It seems that in the last stage of pregnancy and around calving, dams lose more Zn than they ingest, their Zn reserves are depleted and Zn plasma concentrations decrease.…”

Section: Discussionmentioning

confidence: 99%

Differences in the occurrence of selenium, copper and zinc deficiencies in dairy cows, calves, heifers and bulls

Pavlata¹,

Podhorský²,

Pechová³

et al. 2005

Vet. Med. - Czech

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This study was conducted to evaluate the mineral status of various bovine categories reared on the same farm, and to monitor the quality of their mineral nutrition in this way. Blood samples were collected on 20 farms in various regions of the CzechRepublicto diagnose the selenium (Se), copper (Cu) and zinc (Zn) status of dairy cows, calves, heifers and bulls. Blood samples were collected from 5 dairy cows and their calves, 5 heifers and, whenever possible, also from 5 bullocks (10 farms). To assess the Cu and Zn status of the cattle, blood serum concentrations of the elements were determined by flame AAS. The Se status assessment was based on the glutathione peroxidase (GSH-Px) activity in whole blood. Dairy cows and calves showed the higher GSH-Px activity in comparison with heifers and bulls (P < 0.001). Overall mean GSH-Px activity in the blood of dairy cows, calves, heifers and bulls was 720.47 ± 174.47 µkat/l, 688.34 ± 204.12 µkat/l, 555.69 ± 318.36 µkat/l and 516.17 ± 214.70 µkat/l, respectively. Se deficiency was diagnosed in 23% of the examined dairy cows (20% herds), 31% calves (25% herds), 51% heifers (50% herds) and in 58% of bulls (50% herds). Dairy cows showed lower Zn and higher Cu concentrations in comparison with the other categories (P < 0.001). Mean Zn concentrations in blood serum of dairy cows, calves, heifers and bulls were 12.21 ± 3.19 µmol/l, 18.91 ± 5.78 µmol/l, 17.80 ± 2.76 µmol/l and 16.69 ± 3.08 µmol/l, respectively. Zn deficiency was diagnosed in 41% of the examined dairy cows (45% herds) and 13% of bulls (10% herds). None of the calf or heifer herds was classified as Zn deficient when Zn deficiency was found in only 9% of calves and 1% of the examined heifers. Mean Cu concentrations in blood serum of dairy cows, calves, heifers and bulls were 13.62 ± 2.62 µmol/l, 10.18 ± 3.22 µmol/l, 10.96 ± 2.52 µmol/l and 11.18 ± 2.40 µmol/l, respectively. Cu deficiency was diagnosed in 28% of the examined dairy cows (20% herds), 70% of calves (80% herds), 65% of heifers (75% herds) and 70% of bulls (60% herds). Deficiency of at least one of the microelements monitored was diagnosed on all investigated farms.

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Effects of inorganic and organic copper supplemented to first-calf cows on cow reproduction and calf health and performance.

Cited by 62 publications

References 0 publications

Microelements in Colostrum and Blood of Cows and their Calves during Colostral Nutrition

Microelements in Colostrum and Blood of Cows and their Calves during Colostral Nutrition

Effects of parenteral supply of iron and copper on hematology, weight gain, and health in neonatal dairy calves

Differences in the occurrence of selenium, copper and zinc deficiencies in dairy cows, calves, heifers and bulls

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