Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549

Zhong, Xiaoyong; Wang, None Li-bo; Dongzhi, Sun

doi:10.1007/s11655-011-0670-x

Cited by 25 publications

(14 citation statements)

References 10 publications

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“…An in vitro study in human colon cancer cells (HT‐29) further revealed that ethanolic extracts of I. obliquus reduced the levels of CDK2 and CDK4, increased the expression of p53, p21, and p27, and arrested the proliferation of the cancer cells at the G 1 phase (Lee, Kim, & Kim, ). Similarly, the exposure of human lung adenocarcinoma cell line (A549 cell line) to inotodiol extract from I. obliquus reduced the expression of Ki‐67 and arrested the proliferation of the cells at the S phase in a dose‐dependent manner (Zhong, Wang, & Sun, ). In addition, the exposure of human gastric BGC2823 cell line to 80 mg/L of I. obliquus extract enhanced caspase‐3 and Bax expression and reduced the expression of Bcl‐2 (Zhong, Sun, Gao, et al, ).…”

Section: Inhibitory Effect Of I Obliquus Extracts On Tumor Growth Anmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Inhibitory Effect Of I Obliquus Extracts On Tumor Growth Anmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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“…Traditional medicines derived from medicinal mushrooms are increasingly being used to treat a wide variety of clinical conditions (Youn et al, 2009) and anticancer studies of active ingredients extracted from mushrooms have become a research hotspot in the recent years (Zhong et al, 2011). Indeed, approximately 700 species of medicinal mushrooms have been found to inhibit the growth of different kinds of cancers (Lemiezek et al, 2011).…”

Section: Mushroomsmentioning

confidence: 99%

“…In recent years, more than 20 different kinds of bioactive components have been found in I. obliquus, including triterpenoids, polyphenols, steroids, b-glucan, peptides, and polysaccharides, suggesting a high medicinal value and good prospects for market development (Hu et al, 2009;Song et al, 2013). Triterpenoids such as inotodiol, lanosterol, and trametenolic acid are considered the main antitumor ingredients being able to induce growth inhibition, cell cycle arrest, and apoptosis in different cancer cells; however, the exact molecular mechanisms by which these effects occur are still not well understood (Chung et al, 2010;Du et al, 2011;Nomura et al, 2008;Youn et al, 2009;Zhong et al, 2011). Polysaccharides from I. obliquus can indirectly be involved in anticancer processes mainly via stimulating the immune system (Lee et al, 2009;Song et al, 2013).…”

Section: Mushroomsmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants. Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years. Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA (http://herba.folklore.ee/), containing altogether more than 30 000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.

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“…34 Recent literature has extensively documented antioxidant, antitumor, and hypoglycemic activity. [35][36][37][38][39] The agent is used in Japan for a variety of benign and malignant conditions. Sandbath treatment.…”

Section: 33mentioning

confidence: 99%

Evidence That Naturopathic Therapy Including Cordyceps sinensis Prolongs Survival of Patients With Hepatocellular Carcinoma

Niwa¹,

Matsuura²,

Murakami³

et al. 2012

Integr Cancer Ther

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Hypothesis. Naturopathic treatment will benefit patients with hepatocellular carcinoma (HCC). Study design. Retrospective analysis of case series of HCC patients treated with naturopathic agents. Methods. HCC was diagnosed by dynamic computed tomography (CT) imaging and α-fetoprotein (AFP) or PIVKA II, or by histology. Tumor staging was determined by CT. A modified Childs-Pugh scoring was used to assess liver disease. Patients were treated with orally administered combinations of 12 naturopathic agents. Patients were monitored clinically and by CT tumor imaging, serial tumor markers, and liver function tests. Results. Patient characteristics: 101 patients with HCC (67 men and 34 women, age 67.2 ± 8.8 years) were treated for a median of 13.4 months (range 0.8-100.8). Of these 84% had cirrhosis, 63% had hepatitis C virus, 18% had hepatitis B virus, 1% had both, and 9% had metastatic disease. Median modified Childs-Pugh score was 6 (range 3-13). Barcelona Clinic Liver Cancer tumor stages of 0, A, B, C, and D were found in 36%, 25%, 20%, 14%, and 6%, respectively. Median AFP was 40 (range 0-311,000). Median PIVKA II was 59 (0-378,000). Previous treatment was included none (27%), resection with relapse (20%), transarterial chemoembolization (50%), radiofrequency ablation (28%), percutaneous ethanol injection therapy (15%), chemotherapy (14%). Outcomes: Initial treatment was with 2.6 ± 0.8 agents (range 2-4). Overall, patients were treated with 3.7 ± 1.2 agents (range 2-7). There was a significant correlation between number of agents administered and survival (P < .0001). Patients treated with ≥4 agents survived significantly longer than patients treated with ≤3 agents (40.2 vs 6.4 months, P < .0001). This difference could not be attributed to statistically significant differences in severity of liver disease or tumor stage, delay in treatment, previous treatment, concurrent nondrug treatment, or censoring effects. The greatest effect was seen in patients treated with at least 4 agents that included Cordyceps sinensis. This prolonged survival was without toxic side effects and appeared to potentiate the survival benefit of conventional therapy. Conclusion. Treatment of HCC with a regimen of ≥4 agents prepared from natural products was associated with prolonged survival in a substantial portion of patients. The data provide level II evidence for the efficacy of naturopathic therapy in HCC.

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Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549

Abstract: Inotodiol can inhibit proliferation and induce the apoptosis of A549 cells, and its molecular mechanism may be associated with the up-regulating expression of p53 and bax proteins and down-regulating expression of Bcl-2 protein, which arrested A549 cells in S phase.

Cited by 25 publications

References 10 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Evidence That Naturopathic Therapy Including Cordyceps sinensis Prolongs Survival of Patients With Hepatocellular Carcinoma

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