Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

Zhong, Rui; Li, Zhuan; Chen, Qingling; Zhang, Hanyu; Zhang, Xinyue; Lin, Weihong

doi:10.1186/s12888-022-04154-0

Cited by 4 publications

References 48 publications

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Dysregulation of the Suprachiasmatic Nucleus Disturbs the Circadian Rhythm and Aggravates Epileptic Seizures by Inducing Hippocampal GABAergic Dysfunction in C57BL/6 Mice

Liang,

Zhao

et al. 2024

Journal of Pineal Research

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The interplay between circadian rhythms and epilepsy has gained increasing attention. The suprachiasmatic nucleus (SCN), which acts as the master circadian pacemaker, regulates physiological and behavioral rhythms through its complex neural networks. However, the exact role of the SCN and its Bmal1 gene in the development of epilepsy remains unclear. In this study, we utilized a lithium–pilocarpine model to induce epilepsy in mice and simulated circadian disturbances by creating lesions in the SCN and specifically knocking out the Bmal1 gene in the SCN neurons. We observed that the pilocarpine‐induced epileptic mice experienced increased daytime seizure frequency, irregular oscillations in core body temperature, and circadian gene alterations in both the SCN and the hippocampus. Additionally, there was enhanced activation of GABAergic projections from the SCN to the hippocampus. Notably, SCN lesions intensified seizure activity, concomitant with hippocampal neuronal damage and GABAergic signaling impairment. Further analyses using the Gene Expression Omnibus database and gene set enrichment analysis indicated reduced Bmal1 expression in patients with medial temporal lobe epilepsy, potentially affecting GABA receptor pathways. Targeted deletion of Bmal1 in SCN neurons exacerbated seizures and pathology in epilepsy, as well as diminished hippocampal GABAergic efficacy. These results underscore the crucial role of the SCN in modulating circadian rhythms and GABAergic function in the hippocampus, aggravating the severity of seizures. This study provides significant insights into how circadian rhythm disturbances can influence neuronal dysfunction and epilepsy, highlighting the therapeutic potential of targeting SCN and the Bmal1 gene within it in epilepsy management.

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Dysregulation of the Suprachiasmatic Nucleus Disturbs the Circadian Rhythm and Aggravates Epileptic Seizures by Inducing Hippocampal GABAergic Dysfunction in C57BL/6 Mice

Liang,

Zhao

et al. 2024

Journal of Pineal Research

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Relationships between students' stress, anxiety and depression and; parents' obsessive‒compulsive disorder

Rezvanpour,

Ganjeh,

Rafiei

et al. 2024

Preprint

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Background According to the World Health Organization, stress disorders, anxiety and depression are among the most common mental disorders in the adolescent age group. These disorders have a lot of negative effects on the educational process, social relations and mental and physical health of teenagers. Currently, among mental disorders, the impact of parental depression and anxiety on children's depression and anxiety is known and accepted, but studies conducted on the impact of other parental mental disorders on children's health are limited. Obsessive compulsive disorder is an important mental disorder due to its prevalence and associated disabilities, and patients with obsessive compulsive disorder have an adverse effect on the quality of life of their relatives. Therefore, this study was conducted with the aim of investigating the relationships between parents' obsessive‒compulsive disorder and students' stress, anxiety, and depression. Methods In this descriptive-analytical and cross-sectional study, 378 students aged 12 to 15 years from Arak city and their parents were selected by simple random cluster sampling. The data were collected via two standard questionnaires, the Maudsley Obsession Scale and the Stress, Anxiety and Depression Questionnaire (DASS-21), and were analyzed via SPSS 26 software. Results According to the findings of this research, the prevalence rates of stress, anxiety and depression at mild to very severe levels among the students were 32%, 40.7% and 36.3%, respectively. The percentage of obsessive-compulsive disorder in the parents of the study was 14.5%. There was a positive and significant relationship between students' stress and anxiety and parents' obsessive‒compulsive disorder (p = 0.0001), but no significant relationship was observed between depression and parents' obsessive‒compulsive disorder (p = 0.181). Conclusions The presence of obsessive‒compulsive disorder in parents was associated with greater stress and anxiety in students, and the presence of obsessive‒compulsive disorder in parents increased the severity of these disorders; however, the presence of obsessive‒compulsive disorder in parents was not related to students' depression. Trial registration: Arak University of Medical Sciences. ID: IR.ARAKMU.REC.1402.207

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Drug-resistant epilepsy: Current concepts, pathogenesis, risk factors, outcomes of surgical treatment

Tibekina,

Al-Sahli,

Flud

2024

Acta biomedica scientifica

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Despite the wide choice of antiepileptic drugs (AEDs), a third of patients remain resistant to the effects of modern AEDs. Drug-resistant epilepsy (DRE) is characterized by the inability to control seizures in a patient when using at least two adequate AED regimens at an effective daily dose as monotherapy or in combination. In this case, the mechanisms responsible for drug resistance are mainly either increased excretion of AEDs by transporters from epileptogenic tissue (the multidrug transporter hypothesis) or a decrease in the sensitivity of drug receptors in epileptogenic brain tissue. It is assumed that there are other mechanisms, but they remain understudied. A number of factors are associated with the risk of DRE developing in patients with diagnosed epilepsy, including genetic, iatrogenic, brain malformations, and others. Patients with DRE have a higher probability of developing psychopathological disorders (depression, anxiety, psychosis), the proportion of which is significantly higher than in the general population. They have a 10-fold increased risk of death due to injury, cognitive decline, and sudden unexpected death in epilepsy (SUDEP). The priority treatment method for DRE is surgery. Early identification of DRE is critical for identifying potential treatment alternatives and determining whether a patient is a surgical candidate. Analysis of data from clinical and instrumental research of operated patients with DRE in the early and late postoperative period will allow us to identify factors of unfavorable outcome and to increase the effectiveness of treatment for this category of patients.The aim was to study and to summarize literature data on the pathogenesis and risk factors of drug resistance to antiepileptic drugs in patients with epilepsy, justifying the need for timely identification of drug resistance and referral of patients with drugresistant epilepsy to specialized centers for possible surgical treatment.

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Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

Cited by 4 publications

References 48 publications

Dysregulation of the Suprachiasmatic Nucleus Disturbs the Circadian Rhythm and Aggravates Epileptic Seizures by Inducing Hippocampal GABAergic Dysfunction in C57BL/6 Mice

Dysregulation of the Suprachiasmatic Nucleus Disturbs the Circadian Rhythm and Aggravates Epileptic Seizures by Inducing Hippocampal GABAergic Dysfunction in C57BL/6 Mice

Relationships between students' stress, anxiety and depression and; parents' obsessive‒compulsive disorder

Drug-resistant epilepsy: Current concepts, pathogenesis, risk factors, outcomes of surgical treatment

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