Effects of Inspiratory Muscle Training on Autonomic Activity, Endothelial Vasodilator Function, and N-Terminal Pro-brain Natriuretic Peptide Levels in Chronic Heart Failure

Laoutaris, Ioannis D.; Dritsas, Athanasios; Brown, Margaret D.; Manginas, Athanassios; Kallistratos, Manolis S.; Chaidaroglou, Antigoni; Degiannis, Dimitrios; Alivizatos, Peter A.; Cokkinos, Dennis V.

doi:10.1097/01.hcr.0000314203.09676.b9

Cited by 58 publications

(96 citation statements)

References 29 publications

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“…The time elapsed to task failure is defi ned as the inspiratory endurance time [8••]. In their studies with CHF patients, Laoutaris et al [9][10][11] have assessed inspiratory muscle endurance by asking subjects to maintain PI max over time (from residual volume to total lung capacity) to obtain sustained maximal inspiratory pressure, expressed as the area under the pressure-time curve.…”

Section: Inspiratory Muscle Testingmentioning

confidence: 99%

Respiratory muscle function and exercise intolerance in heart failure

Ribeiro

Chiappa²,

Neder³

et al. 2009

Curr Heart Fail Rep

106

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Inspiratory muscle weakness (IMW) is prevalent in patients with chronic heart failure (CHF) caused by left ventricular systolic dysfunction, which contributes to reduced exercise capacity and the presence of dyspnea during daily activities. Inspiratory muscle strength (estimated by maximal inspiratory pressure) has independent prognostic value in CHF. Overall, the results of trials with inspiratory muscle training (IMT) indicate that this intervention improves exercise capacity and quality of life, particularly in patients with CHF and IMW. Some benefit from IMT may be accounted for by the attenuation of the inspiratory muscle metaboreflex. Moreover, IMT results in improved cardiovascular responses to exercise and to those obtained with standard aerobic training. These findings suggest that routine screening for IMW is advisable in patients with CHF, and specific IMT and/or aerobic training are of practical value in the management of these patients.

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Section: Inspiratory Muscle Testingmentioning

confidence: 99%

Respiratory muscle function and exercise intolerance in heart failure

Ribeiro

Chiappa²,

Neder³

et al. 2009

Curr Heart Fail Rep

106

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“…Consequently, respiratory muscle has been the target of a substantial number of respiratory muscle training trials in patients with CHF [15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Respiratory muscle training induces changes in measurements of respiratory muscle function such as PI max .…”

Section: Introductionmentioning

confidence: 99%

Biological variation, reference change value (RCV) and minimal important difference (MID) of inspiratory muscle strength (PImax) in patients with stable chronic heart failure

et al. 2015

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“…In a non-randomized trial, Laoutaris et al 32 compared high intensity versus low intensity IMT in patients with CHF. The high-intensity training regimen involved repetitive efforts at 60% PImax until exhaustion, whereas the low intensity group trained at 15% of PImax with only six inspiratory efforts.…”

Section: Weeksmentioning

confidence: 99%

Treinamento muscular inspiratório em pacientes com insuficiência cardíaca: metanálise de estudos randomizados

Plentz¹,

Sbruzzi²,

Ribeiro³

et al. 2012

Arq. Bras. Cardiol.

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Patients with chronic heart failure (CHF) may have lower inspiratory muscle strength and endurance, which may contribute to exercise intolerance. Inspiratory muscle training (IMT) can have beneficial effects on these patients. Thus, the aim of this study was to systematically review the effects of IMT compared to control groups (placebo-IMT or another intervention) in patients with CHF. A search of databases (MEDLINE, Cochrane CENTRAL and PEDro) and references of published studies, from 1960 to 2011, was conducted. Randomized trials comparing IMT to control groups in the treatment of patients with CHF were included. The GRADE approach was used to determine the quality of evidence for each outcome. Of 119 articles identified, 7 studies were included. IMT increased the distance walked in the six-minute walk test [69 m (95% CI: 7.21 to 130.79)] (very low evidence) and maximal static inspiratory pressure [23.36 cmH20 (95% CI: 11.71 to 35.02)] (low evidence) compared to control groups. However, IMT provides a significant improvement in peak oxygen consumption only in the studies that performed IMT for 12 weeks against no inspiratory load in patients with inspiratory muscle weakness [3.02 ml/kg/min-1 (95% CI: 0.43 to 5.61)]. IMT improves functional capacity and inspiratory muscle strength thereby deserving consideration as an additional intervention in patients with CHF. Larger and better-designed studies, however, are needed to clarify the potential benefit of IMT in this patient population.

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Effects of Inspiratory Muscle Training on Autonomic Activity, Endothelial Vasodilator Function, and N-Terminal Pro-brain Natriuretic Peptide Levels in Chronic Heart Failure

Abstract: Improvement in dyspnea and exercise tolerance after IMT were not associated with changes in markers of HRV, endothelial function, and NT-proBNP in patients with mild to moderate chronic heart failure. Further studies on the effects of IMT in advanced heart failure would be worthwhile.

Cited by 58 publications

References 29 publications

Respiratory muscle function and exercise intolerance in heart failure

Respiratory muscle function and exercise intolerance in heart failure

Biological variation, reference change value (RCV) and minimal important difference (MID) of inspiratory muscle strength (PImax) in patients with stable chronic heart failure

Treinamento muscular inspiratório em pacientes com insuficiência cardíaca: metanálise de estudos randomizados

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