Effects of Insulin‐Like Growth Factor 1 on Neutrophil and Monocyte Functions in Normal and Septic States

Balteskard, Lise; Unneberg, Kjetil; Halvorsen, Dag S.; Hansen, John‐Bjarne; Revhaug, Arthur

doi:10.1177/0148607198022003127

Cited by 23 publications

(18 citation statements)

References 44 publications

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“…From these findings, it was suggested that IGF-I expression in AMC may be linked to the state of cell activation. IGF-I has been shown to enhance phagocytic activity of neutrophils in vitro when they were challenged with E coli [54] . It was demonstrated by Inoue et al [55] that IGF-I increased the killing capacity and phagocytosis of peritoneal macrophages when they were activated by E coli.…”

Section: Nature Of Amcmentioning

confidence: 99%

From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain

Kaur

Dheen

Ling

2007

Acta Pharmacologica Sinica

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Amoeboid microglial cells (AMC) in the developing brain are active macrophages. The macrophagic nature of these cells has been demonstrated by many methods, such as the localization of various hydrolytic enzymes and the presence of complement type 3 surface receptors in them. More importantly is the direct visualization of these cells engaged in the phagocytosis of degenerating cells at the ultrastructural level. Further evidence of them being active macrophages is the avid internalization of tracers administered by the intravenous or intraperitoneal routes in developing rats. The potential involvement of AMC in immune functions is supported by the induced expression of major histocompatibility complex class I and II antigens on them when challenged by lipopolysaccharide or interferon-γ. Immunosuppressive drugs, such as glucocorticoids and immune function-enhancing drugs like melatonin, affect the expression of surface receptors and antigens and the release of cytokines by AMC. Recent studies in our laboratory have shown the expression of insulin-like growth factors, endothelins, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and N-methyl-D-asparate receptors. This along with the release of chemokines, such as stromal derived factor-1a and monocyte chemoattractant protein-1, suggests multiple functional roles of AMC in early brain development.

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Section: Nature Of Amcmentioning

confidence: 99%

From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain

Kaur

Dheen

Ling

2007

Acta Pharmacologica Sinica

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“…Table 2 WBC and circulating leukocyte subpopulations determined by FACScan analysis of blood drawn from sham-operated mice (LAP), saline-treated septic mice (CLP), and septic mice treated with either GH (CLP/GH), IGF-I (CLP/IGF), or a combination of GH and IGF-I (CLP/G + I) In contrast to GH we observed an immunomodulatory effect of IGF-I. As for GH, an immunomodulatory effect of this peptide was proposed but data about an IGF-I-induced immunomodulation during systemic inflammation are limited [8,9,12,17,[26][27][28]41,42]. In general it was noticed that IGF-I promoted the proliferation and differentiation of myeloid lineage cells and lymphocyte precursor cells, augmented PMN bactericidal capacity and migration, and enhanced in vitro cytokine production [12,15,[26][27][28]41,42].…”

Section: Discussionmentioning

confidence: 83%

“…Dosages of GH ranging between 0.05 and 5 mg/ kg/day have been used and were effective in inducing a physiological response in humans and experimental animals [13,[18][19][20]. Concerning IGF-I these dosages range between 1 and 24 mg/kg/day [17,16,[21][22][23]. We therefore decided to use a moderate dosage of GH and IGF-I respectively that ensures a physiologic response.…”

Section: Drug Administrationmentioning

confidence: 99%

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Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I)

Schmitz

Kobbe

Lendemanns

et al. 2008

Growth Hormone & IGF Research

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“…Additionally, weaning is associated with an increase in somatotropin concentration and a decrease in the concentration of insulin-like growth factors 1 and 2 (IGF-1 and IGF-II) (Matteri et al 2000, Kojima et al 2008). Higher IGF-1 concentrations are correlated with greater microbicidal capacity (Balteskard et al 1998). Thus, the increase of corticosteroid serum levels (Liu et al 1999) is related to an inhibition of apoptosis and a more efϐicient elimination of apoptotic PMNLs by macrophages.…”

Section: Discussionmentioning

confidence: 99%

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

et al. 2012

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Pesq. Vet. Bras. 32(8) The weaning period of piglets is characterized by physiological alterations, such as decreased weight gain, increased reactive oxygen species (ROS) and increased serum cortisol levels with possible effects on the immune response. The effect of parenteral administration of vitamins A, D and E on production performance, oxidative metabolism, and the function of polymorphonuclear leukocytes (PMNLs) was assessed in piglets during the weaning period. The sample was comprised of 20 male piglets that were given an injectable ADE vitamin combination (135,000 IU vitamin A, 40,000 IU vitamin D and 40mg vitamin E/ animal) at 20 and 40 days of age. Weight gain, concentration of reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and the microbicidal and phagocytic activity of PMNLs were assessed. No difference was observed in the average piglet weight during the study; however, a greater percentage of weight gain was observed after weaning in the treated group. The concentrations of GSH and SOD did not differ between groups, although lipid peroxidation was greater in the control group at 60 days of age. The investigated variables of oxidative metabolism were correlated as follows: -0.41 for GSH and MDA, -0.54 for GSH and SOD and 0.34 for MDA and SOD. The intensity of intracellular ROS production, the percentage of ROS-producing PMNLs and the intensity of phagocytosis by PMNLs did not differ between treatment groups. Administration of the injectable ADE combination improved the percentage of weight gain between 20 and 40 days of age, decreased oxidative stress at 60 days of age and did not inϐluence the function of PMNLs in piglets.INDEX TERMS: Immune response, weaning, piglets, GSH, MSD and SOD. lógicas como menor ganho de peso, aumento na produção de espécies reativas de oxigênio (EROs) e aumento na concentração plasmática de cortisol com possíveis implicações para a resposta imune. Foi avaliado o efeito da administração parenteral das vitaminas A, D e E sobre o desempenho produtivo, o metabolismo oxidativo e a função de leucócitos polimorfonucleares (PMNLs) em suínos durante esta fase de crescimento. Foram utilizados 20 leitões, machos, com 20 dias de idade que receberam ADE injetável (135.000 UI vitamina A, 40.000 UI vitamina D e 40mg vitamina E/animal), aos 20 e 40 dias de idade. Foi determinado o ganho de peso e as concentrações de glutationa reduzida (GSH), malondialdeído (MDA) e superóxido dismutase (SOD) e a

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Effects of Insulin‐Like Growth Factor 1 on Neutrophil and Monocyte Functions in Normal and Septic States

Abstract: IGF-1 serves as a priming agent for biologic functions of leukocytes.

Cited by 23 publications

References 44 publications

From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain

From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain

Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I)

Parenteral administration of vitamins A, D and E on the oxidative metabolism and function of polymorphonuclear leukocytes in swine

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