Effects of insulin-like growth factor 1 on pathologic processes in the cuprizone model of multiple sclerosis

Fedorishin, D.; Сорокина, И. В.; Толстикова, Т. Г.; Akulov, Andrey E.; Glazacheva, Valentina; Nemirovich-Danchenko, Nikolay M.; Khodanovich, M. Yu.; Yarnykh, Vasily L.

doi:10.1088/1742-6596/886/1/012005

Cited by 2 publications

(1 citation statement)

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“…IGF-1 is involved in the regulation of the immune system, oligodenerocyte proliferation, and survival (El-Tamawy et al 2016 ). Fedorishin et al ( 2017 ) evaluated the effect of IGF-1 on demyelination and reported that IGF-1 treatment reduce the clinical deficits, size, and number of lesion.…”

Section: Discussionmentioning

confidence: 99%

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Nageeb

Hashim

Fawzy

2018

Egypt J Neurol Psychiatry Neurosurg

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BackgroundMultiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients.MethodsThis study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale.ResultsThere was no significant difference between patients and controls regarding serum IGF-1 levels (P = 0.19). However, low serum levels of IGF-1 have significantly greater odds for fatigue (P = 0.002) and cognitive impairment (P < 0.001). Also, serum IGF-1 levels have a significant negative correlation with MFIS (r = − 0.701 and P < 0.001) and a significant positive correlation with MoCA scale (r = + 0.84 and P < 0.001).ConclusionsThe results, specifically that low levels of serum IGF-1 was associated with cognitive impairment and fatigue in MS, suggest that IGF-I may be involved in the pathogenesis of cognitive deficits and fatigue in MS disease.

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Section: Discussionmentioning

confidence: 99%