Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter

Saito, Motoaki; Weiß, Robert M.; Latifpour, Jamshid

doi:10.1046/j.1442-2042.1999.00074.x

Cited by 4 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is seen despite reduced responses to exogenous ET-1, which has been reported with vascular rings from humans with insulin resistance or diabetes [148] and in subjects with type 2 diabetes [149]. Increased tissue levels of ET-1 receptors have also been described in arteries from humans with type 2 diabetes [150,151]. This finding suggests that the downregulated response to ET-1 is due to changes in other downstream components of the receptor signaling cascade.…”

Section: Vascular Origins Of Impaired Insulin Actionmentioning

confidence: 52%

Interactions of Endothelin and Insulin: Expanding Parameters of Insulin Resistance

Strawbridge¹,

Elmendorf²,

Mather

2006

CDR

View full text Add to dashboard Cite

Since the discovery of endothelin peptides in the mid-1980s by Yanigasawa and colleagues, accumulating evidence demonstrates that these peptides may function beyond vasoconstriction. Strong epidemiologic associations between insulin resistance and increased endothelin levels or activity have been found, and these associations have prompted studies investigating the interactions of endothelin with insulin. In this review we explore the evidence for such interactions at multiple levels of physiology, ranging from effects on tissue perfusion through modulation of vascular tone to subcellular interactions of endothelin signaling with insulin signaling. The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed.

show abstract

Section: Vascular Origins Of Impaired Insulin Actionmentioning

confidence: 52%

Interactions of Endothelin and Insulin: Expanding Parameters of Insulin Resistance

Strawbridge¹,

Elmendorf²,

Mather

2006

CDR

View full text Add to dashboard Cite

show abstract

“…Up to nowadays, it was shown in rabbit, human and canine urinary tract that ET-1 produces significant contractile responses of smooth muscle in bladder dome, trigone, and urethra (Langenstroer et al 1997, Okamoto-Koizumi et al 1999, Wada et al 2000, and immunohistochemistry studies in dogs located ET-1 to epithelial elements of these organs (Langenstroer et al 1997). ET A receptors were found in rabbit and rat ureter by binding studies (Latifpour et al 1995, Nakamura et al 1997, and there are proofs that these receptors are upregulated in diabetes (Saito et al 1999) and after ligation of ureter (Feldman et al 2000). Although in a study on isolated human ureter contractile effect of Vol.…”

Section: Introductionmentioning

confidence: 99%

Contractile Effects of Endothelins on Isolated Human Ureter

Janković

Janković²,

Stojanović³

et al. 2011

Physiol Res

View full text Add to dashboard Cite

The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10-11 M - 5.05x10-8 M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ETA receptors BQ123 and selective antagonist of ETB receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA2=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA2=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ETA and ETB receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ETA and ETB receptors.

show abstract

Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes

Yono

Pouresmail

Takahashi

et al. 2005

Naunyn Schmied Arch Pharmacol

View full text Add to dashboard Cite

To examine the differences between spontaneous and streptozotocin (STZ)-induced diabetes, four parallel studies were performed; three studies of diabetes-prone BB (BBDP/Wor) rats maintained for 8, 16, and 32 weeks and one study of STZ-injected diabetes-resistant BB (BBDR/Wor) rats maintained for 32 weeks. Each diabetic study has three groups of rats: a control group; a euglycemic group, which received sufficient amounts of insulin; and a hyperglycemic group, which received a suboptimal dose of insulin. The extent of tissue weight changes was generally shown to be less dramatic in the euglycemic diabetic than in the hyperglycemic diabetic rats. STZ-induced diabetes increased the bladder weight more dramatically (up to 3-fold) than did spontaneous diabetes (up to 2-fold). Furthermore, a significant decrease in the size of the adrenal gland (20%) and testis (10%) is observed only with spontaneous diabetes, whereas a significant decrease in the size of the ventral prostate (30%) is observed only with STZ-induced diabetes, although the serum testosterone levels are similar in both groups. Our data demonstrate that there are differences in the effect of insulin treatment on the tissue size of the genitourinary tract between spontaneously developed and streptozotocin-induced diabetes in BB rats.

show abstract

Effects of insulin treatment on diabetes‐induced alterations in endothelin receptors in rat ureter

Cited by 4 publications

References 23 publications

Interactions of Endothelin and Insulin: Expanding Parameters of Insulin Resistance

Interactions of Endothelin and Insulin: Expanding Parameters of Insulin Resistance

Contractile Effects of Endothelins on Isolated Human Ureter

Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes

Contact Info

Product

Resources

About