1979
DOI: 10.1128/aac.16.6.781
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Effects of Interferon and Adenine Arabinoside Treatment of Hepatitis B Virus Infection on Cellular Immune Responses

Abstract: Fifteen patients with chronic hepatitis B were treated with adenine arabinoside (Ara-A) or human leukocyte interferon (HLI). Cellular immune response to hepatitis B virus surface antigen and antigens prepared from herpes simplex virus, varicella zoster virus, and cytomegalovirus was measured by a lymphocyte blast transfornation assay and an assay for interferon production. Measurements were made before, during, and after antiviral treatment. Unlike patients convalescing from acute hepatitis B, only 2 of 15 pat… Show more

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Cited by 25 publications
(3 citation statements)
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“…Attempts in the early 1980 s to block HBV replication using inhibitors of viral DNA synthesis were generally unsuccessful because of the poor efficacy and/or toxicity of available drugs, for example, as found with adenosine arabinoside [8][9][10][11][12][13][14][15]. Moreover, with the lack at that time of tissue culture and in vitro systems for virus growth or viral polymerase expression, which were suitable for high throughput screening, antiviral compound libraries could not be tested against HBV.…”
Section: Introductionmentioning
confidence: 96%
“…Attempts in the early 1980 s to block HBV replication using inhibitors of viral DNA synthesis were generally unsuccessful because of the poor efficacy and/or toxicity of available drugs, for example, as found with adenosine arabinoside [8][9][10][11][12][13][14][15]. Moreover, with the lack at that time of tissue culture and in vitro systems for virus growth or viral polymerase expression, which were suitable for high throughput screening, antiviral compound libraries could not be tested against HBV.…”
Section: Introductionmentioning
confidence: 96%
“…In chronic hepatitis B, ara-A, administered alone or in combination with interferon, inhibits viral replication and in some patients brings about a disappearance of Dane particles from blood [29,30] and liver [30]. However, ara-A produces side effects, such as gastrointestinal and neurological disturbances, which can necessitate discontinuation of the therapy [33]; it also cause a marked lymphocytopenia which may affect the outcome of the treatment since succesful antiviral therapy appears to require the cooperation of the host immune response [34]. Selective concentration of ara-A or ara-AMP into hepatocytes, as achieved by coupling ara-AMP to GSA, should reduce the side effects and improve the efficacy of the treatment.…”
Section: [Methyl-3h/thymidinementioning
confidence: 99%
“…In the beginning, we thought that the patient's NK cells were refractory to interferon since (1) circulating NK levels were not elevated after 44 days of treatment (Table 4) and (2) there was no consistent immediate elevation of NK activity 5 h to seven days after a dose of interferon (Table 5). However, circulating NK levels rose after about three months of therapy and 100 million units of interferon (periods A-C, Tables 1 and 4).…”
Section: Discussionmentioning
confidence: 99%