Effects of Interferon-α on Depressive-Like Behavior and Brain Neurochemistry in Rats Housed in Standard and Overcrowding Conditions

Loginova, N. A.; Loseva, E. V.; Sarkisova, K. Yu.; Kudrin, V. S.

doi:10.1134/s0022093023060108

Cited by 1 publication

(2 citation statements)

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“…Although several previous studies have reported that overcrowding induces changes in 5-HT [61,62], TNF-a [63], SOD [64], and MDA [65,66] levels, further study with control nonstressed animals are required to provide more convincing evidence on the role of AKE as antidepressant by modulating the brain neurotransmitters, pro-inflammatory cytokines, and antioxidant signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

“…This fact limits the conclusion drawn from the brain neurotransmitter, pro-inflammatory cytokine, and oxidative stress markers, as it cannot be discerned as to whether overcrowding causes changes to these parameters and whether AKE treatments reversed them. Although several previous studies have reported that overcrowding induces changes in 5-HT [61,62], TNF-a [63], SOD [64], and MDA [65,66] levels, further study with control non-stressed animals are required to provide more convincing evidence on the role of AKE as anti-depressant by modulating the brain neurotransmitters, pro-inflammatory cytokines, and antioxidant signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

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Angelica keiskeileaves extract attenuates psychosocial stress in overcrowding-subjected rats

Siswanto

2024

Preprint

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Angelica keiskei is currently used as a popular functional food with various beneficial effects, including antioxidant, anti-obesity, anti-tumor, anti-diabetic, and anti-bacterial. A recent in vitro study reported that A. keiskei inhibits monoamine oxidases (MAOs), suggesting the antidepressant property of A. keiskei. However, in vivo studies on laboratory animals subjected to psychosocial stress have not been conducted. In this study, the effects of an A. keiskei leaves extract (AKE) on rats undergoing chronic social overcrowding stress were explored. Six-month-old male and female Wistar rats were housed in groups of three in 12 x 12 x 18 cm cages (overcrowding) for twenty-eight days. Both male and female rats were divided into two groups (N = 10); control group received oral distilled water, whilst the other group (treatment group) received 20 mg/kgBW/day of AKE supplementation. The results showed that AKE-treated rats exhibited lower anxiety- and depressive-related behaviors than that of control stressed rats. AKE significantly decreased corticosterone and increased testosterone and estrogen levels in stressed rats. Additionally, brain tissue MDA and TNF-alpha levels were reduced, while brain neurotransmitter 5-HT and antioxidant SOD levels were elevated by the AKE. These findings suggest, for the first time, that AKE could alleviate overcrowding stress-induced behavioral, neuroendocrine, antioxidant, and inflammatory dysfunctions. A. keiskei leaves extract could potentially be used as an agonist to reduce stress and depression.

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