Effects of Interleukin-17A on the Early Stages of Arterial Thrombosis in Mice

Park, Youngseon; Shim, Yeseul; Kwon, Il; Lee, Heow Won; Nam, Hyo Suk; Choi, Hyun-Jung; Heo, Ji Hoe

doi:10.3349/ymj.2022.63.7.632

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Platelets can express the IL-17A receptor (IL-17RA) ( 271 ). Earlier studies have described that IL-17A induces platelet aggregation and activation, regulates the release of NETs to enhance neutrophil infiltration, and promotes deep vein thrombosis ( 229 ). As anticipated, IL-17A monotherapy was found to inhibit platelet activation and neutrophil activity in a mouse model ( 230 ).…”

Section: Treatment Of Dvt Via Netsmentioning

confidence: 99%

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Yao,

Ma,

et al. 2023

Front. Immunol.

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Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate. To date, its underlying mechanisms are not fully understood, and patients usually present with clinical symptoms only after the formation of the thrombus. Thus, it is essential to understand the underlying mechanisms of deep vein thrombosis for an early diagnosis and treatment of DVT. In recent years, many studies have concluded that Neutrophil Extracellular Traps (NETs) are closely associated with DVT. These are released by neutrophils and, in addition to trapping pathogens, can mediate the formation of deep vein thrombi, thereby blocking blood vessels and leading to the development of disease. Therefore, this paper describes the occurrence and development of NETs and discusses the mechanism of action of NETs on deep vein thrombosis. It aims to provide a direction for improved diagnosis and treatment of deep vein thrombosis in the near future.

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Section: Treatment Of Dvt Via Netsmentioning

confidence: 99%

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Yao,

Ma,

et al. 2023

Front. Immunol.

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“…However, recent studies suggest that leukocytes and inflammation contribute to thrombosis. 1 2 The formation of intravascular thrombi plays a protective role against bacterial infection by immobilizing bacteria and, thus, restricting their invasion of the tissue. 3 Therefore, thrombosis and inflammation are mutually reinforcing processes.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Recruitment in Arterial Thrombus and Characteristics of Stroke Patients with Neutrophil-Rich Thrombus

Cha

Lee

et al. 2022

Yonsei Med J

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Purpose Neutrophils contribute to thrombosis. However, there is limited information on the temporal course of neutrophil recruitment in thrombosis, the contribution of neutrophils to thrombus growth, and the characteristics of stroke patients with neutrophil-rich thrombi. Materials and Methods After inducing carotid artery thrombosis in Institute of Cancer Research mice using ferric chloride, aged thrombi were produced by ligating the distal portion of the carotid artery in mice for 0.5, 1, 2, 3, 6, or 24 h. For thrombus analysis in stroke patients, we used registry data and thrombi that were obtained during intra-arterial thrombectomy. Immunohistochemistry was performed to determine thrombus composition. Results In the thrombi of 70 mice, Ly6G positive cell counts (neutrophils) and histone H3-positive cell counts increased in a time-dependent manner (both p <0.001). Ly6G-positive cell count was strongly correlated with histone H3-positive cell counts (r=0.910, p <0.001), but not with thrombus size ( p =0.320). In 75 stroke patients, atrial fibrillation and cardioembolism were more frequent in the higher neutrophil group (32/37, 86.5%) than in the lower neutrophil group (19/38, 50%) ( p =0.002). The median erythrocyte fraction was higher [52.0 (interquartile range 39.9–57.8)] in the higher neutrophil group than in the lower neutrophil group [40.3 (interquartile range 23.5–53.2)]. The fraction of neutrophils was positively correlated with that of erythrocytes (R=0.35, p =0.002). Conclusion Neutrophils were recruited and increased in arterial thrombosis in a time-dependent manner; however, they were not associated with the growth of formed thrombi. Neutrophil fractions in the thrombi of stroke patients appeared to be associated with atrial fibrillation and erythrocyte fraction.

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Do interleukin-17 and interleukin-23 inhibitors alter the coagulation parameters in psoriasis patients?: A retrospective study

Ünal,

Yüksek,

Öğüt

et al. 2024

Arch Dermatol Res

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Effects of Interleukin-17A on the Early Stages of Arterial Thrombosis in Mice

Cited by 3 publications

References 40 publications

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Neutrophil Recruitment in Arterial Thrombus and Characteristics of Stroke Patients with Neutrophil-Rich Thrombus

Do interleukin-17 and interleukin-23 inhibitors alter the coagulation parameters in psoriasis patients?: A retrospective study

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