Effects of Interleukin Families Polymorphisms on Systemic Lupus Erythematosus: Focus on Interleukin-1

Moossavi, Maryam; Shojaee, Majid; Mollashahi, Arezoo; Poodineh, Jafar; Moossavi, Seyedeh Zahra; Alaei, Maryam; Ibrahimi, Mostafa; Mohammadoo‐Khorasani, Milad

doi:10.5812/gct.69365

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2022

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“…Cytokines are soluble factors released from immune cells like monocytes, macrophages, and dendritic cells and play a fundamental role in the differentiation, maturation, and functional regulation of different immune cells 8 . Disturbance in cytokines production has been identified in SLE both in vivo and in vitro 9 .…”

Section: Introductionmentioning

confidence: 99%

Il-17f Gene Polymorphism (7488t/C, Rs763780) in Egyptian Patients With Sle

El-Sherbini

AbdAlRaouf²,

El‐Masry³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.

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Section: Introductionmentioning

confidence: 99%