Effects of intermittent theta-burst transcranial magnetic stimulation on post-traumatic stress disorder symptoms: A randomized controlled trial

Yuan, Huiling; Liu, Bin; Li, Fengzhan; Jin, Yinchuan; Zheng, Shi; Ma, Zhujing; Wu, Zhongying; Chen, Chen; Zhang, Liang; Gu, Yanan; Gao, Xing; Yang, Qun

doi:10.1016/j.psychres.2023.115533

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Six narrative reviews, two systematic reviews, six meta-analyses, one Master-level dissertation, three book chapters, one commentary, and one preprint were also kept out of this work. Overall, 31 studies met the inclusion criteria for the data extraction process and, thus, were included in this systematic review [ 26 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…Further, at the 3-month follow-up, the intrusion and hyperarousal PTSD sub-symptoms showed a slight shift back to the baseline, whereas avoidance and negative alterations in cognition and mood continued to improve [ 66 ]. Interestingly, Yuan et al [ 79 ] compared the efficacy of high-frequency rTMS with that of iTBS on seventy-five civilians reporting highly severe PTSD symptoms (i.e., PCL scores ≥ 50). Intervention was characterized by fifteen sessions of sham-controlled 10 Hz rTMS or iTBS targeting the right dlPFC.…”

Section: Resultsmentioning

confidence: 99%

“…Intervention was characterized by fifteen sessions of sham-controlled 10 Hz rTMS or iTBS targeting the right dlPFC. A significant group-by-time interaction was observed, indicating that both the 10 Hz rTMS and iTBS groups showed faster and greater reductions in their overall PTSD symptoms’ severity compared to the sham at the end of the treatment and the 1-month follow-up [ 79 ]. Nevertheless, no significant group differences between the 10 Hz rTMS and iTBS groups were detected in terms of efficacy [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

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Novel Approaches for the Treatment of Post-Traumatic Stress Disorder: A Systematic Review of Non-Invasive Brain Stimulation Interventions and Insights from Clinical Trials

Saccenti,

Lodi,

Moro

et al. 2024

Brain Sciences

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First-line treatments for post-traumatic stress disorder (PTSD) encompass a wide range of pharmacotherapies and psychotherapies. However, many patients fail to respond to such interventions, highlighting the need for novel approaches. Due to its ability to modulate cortical activity, non-invasive brain stimulation (NIBS) could represent a valuable therapeutic tool. Therefore, the aim of this systematic review is to summarize and discuss the existing evidence on the ameliorative effects of NIBS on PTSD and comorbid anxiety and depressive symptoms. Our goal is also to debate the effectiveness of an integrated approach characterized by the combination of NIBS and psychotherapy. This search was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines in the PubMed, PsycINFO, PsycARTICLES, PSYINDEX, MEDLINE, and ERIC databases. Overall, 31 studies met the eligibility criteria, yielding a total of 26 clinical trials employing transcranial magnetic stimulation (TMS) and 5 making use of transcranial direct-current stimulation (tDCS). From these studies, it emerged that NIBS consistently reduced overall PTSD symptoms’ severity as well as comorbid anxiety and depressive symptoms. Moreover, we speculate that combining NIBS with prolonged exposure or cognitive processing therapy might represent a promising therapeutic approach for consistently ameliorating subjects’ clinical conditions.

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