Effects of Internally Administered N-[5-( 4-Aminophenoxy)Pentyl]Phthalimide on Wool Follicles and Skin of Sheep

Chapman, Ralph E.; Rigby, R. D. G.

doi:10.1071/bi9800183

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…Inhibition of mitotic activity in the follicle bulbs in response to mEGF treatment occurred during the first 2-3 days. This was more gradual than that which occurred after administration of depilatory doses of N-[5-(4-aminophenoxy)pentyl]phthalimide (Chapman and Rigby 1980), cyclophosphamide (Reis and Chapman 1974) or mimosine (Reis et al 1975), which inhibited mitotic activity within the first day, but was faster than after dosing with dexamethasone trimethylacetate which caused cessation in about 5 days (Chapman et at. 1982).…”

Section: Discussionmentioning

confidence: 99%

“…The increase in epidermal thickness which occurred in response to mEGF infusion was more pronounced and usually more prolonged than with other compounds previously tested. These latter responses ranged from a moderate and fairly prolonged thickening with N-[5-(4-aminophenoxy)pentyl]phthalimide (Chapman and Rigby 1980) and p-aminophenol (A. M. Downes, personal communication), to an inital decrease followed by a moderate increase with cyclophosphamide (Reis and Chapman 1974) and cortisol (Chapman and Bassett 1970). No changes in epidermal thickness were observed in response to dexamethasone trimethylacetate (Chapman et at.…”

Section: Discussionmentioning

confidence: 99%

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Morphological Changes in the Skin and Wool Fibres of Merino Sheep Infused with Mouse Epidermal Growth Factor

Hollis¹,

Chapman²,

Panaretto³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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Intravenous infusion of 4.5-4.7 mg of mouse epidermal growth factor (mEGF) into nine castrated male Merino sheep for 26 h resulted in complete casting of the fleeces 6-8 days later. The morphological changes which occurred in the skin were studied in skin samples taken before infusion and at intervals between 1 h and 42 days after the infusion had begun. Wool fibres from the shed fleeces were examined with the scanning electron microscope. Increased cell proliferation occurred in the epidermis and sebaceous glands, whereas the wool follicles regressed. Transient dermal haemorrhages occurred during the first 3 h of infusion. The fibre and inner root sheath in the keratogenous zone of 30-40% of the follicles were partially disrupted within the first 6 h of mEGF infusion; catagen began in all follicle bulbs within 24 h. Fibre and inner root sheath production, although markedly reduced, continued in about 60% of follicles which had partially regressed, but production ceased in the remainder in which tapered ends formed on the fibres prior to shedding. Follicles began to regenerate asynchronously 4-8 days after the beginning of infusion and completed their development during the next 3 weeks. The follicle regression and fleece casting induced by mEGF infusion, and subsequent follicle regeneration were completed more rapidly than observed previously with other depilatory agents, and, except for prolonged epidermal thickening, there was no lasting cutaneous abnormality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morphological Changes in the Skin and Wool Fibres of Merino Sheep Infused with Mouse Epidermal Growth Factor

Hollis¹,

Chapman²,

Panaretto³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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“…Doses of selenocystine and selenomethionine that permitted survival of the sheep were insufficient to either stop wool growth or weaken fibres. The presence of large numbers of autophagic vacuoles in follicle bulb cells after dosing sheep with a variety of compounds is associated with subsequent regression of follicles and casting of the fleece (Chapman 1980;Chapman and Rigby 1980). The finding of numerous autophagic vaculoles in follicle bulb cells of sheep given the higher doses of selenocystine thus indicates potential depilatory activity, which cannot be observed due to the toxicity of these doses.…”

Section: Discussionmentioning

confidence: 99%

“…3). Such a finding is indicative of impending regression of wool follicles (Chapman 1980;Chapman and Rigby 1980). Also, a few autophagic vacuoles were seen in most bulb cells before the death of the sheep that received O' 092 mmol kg-o .…”

Section: Selenium-containing Amino Acidsmentioning

confidence: 99%

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Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Reis¹,

Tunks²,

Rigby³

et al. 1983

Aust. Jnl. Of Bio. Sci.

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Sheep were given intravenous infusions of ethionine together with cycloleucine or reduced glutathione, in attempts to prevent the inhibition of wool growth by ethionine. Other sheep were given cycloleucine alone to measure effects on wool growth. Twenty-two compounds related to cystine, methionine, ethionine, lysine, phenylalanine and tyrosine were given as intravenous infusions to sheep to investigate their potential as depilatory agents. Nineteen of these compounds were also tested in mice during their first cycle of hair growth. The concurrent administration of cycloleucine with ethionine prevented the weakening of wool fibres caused by ethionine, but reduced glutathione was ineffective. Cycloleucine weakened wool fibres, as judged subjectively, and caused a small reduction in fibre diameter. Selenocystine and selenomethionine caused some hair loss in mice but selenocystine was also toxic. Both seleno-amino acids were toxic for sheep; selenocystine was lethal at 0·025 mmol kg-o . 75 and selenomethionine at 0·09 mmol kg-O . 75 • Doses that permitted survival of sheep did not have depilatory effects. However, the presence of autophagic vacuoles in the cytoplasm of follicle bulb cells of sheep indicated that a toxic dose of selenocystine had potential depilatory activity. Other compounds investigated did not induce loss of wool or hair. Some compounds, notably 3-methylthiopropionic acid and S-(2-aminoethyl)-L-cysteine, were toxic to mice but not sheep. The methionine analogue, methoxinine (O-methyl-DL-homoserine), caused a substantial reduction in the strength of wool fibres and a prolonged alteration of the crimp pattern. It is suggested tentatively that cycloleucine inhibits methionine adenosyltransferase and thereby reduces or prevents the formation of S-adenosylethionine. The failure of various compounds related to methionine and ethionine to have any depilatory activity in sheep supports the view that ethionine influences wool growth via the formation of S-adenosylethionine.

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Non-human Hair

Chapman¹

1990

Hair and Hair Diseases

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Effects of Internally Administered N-[5-( 4-Aminophenoxy)Pentyl]Phthalimide on Wool Follicles and Skin of Sheep

Cited by 8 publications

References 11 publications

Morphological Changes in the Skin and Wool Fibres of Merino Sheep Infused with Mouse Epidermal Growth Factor

Morphological Changes in the Skin and Wool Fibres of Merino Sheep Infused with Mouse Epidermal Growth Factor

Investigation of Some Amino Acid Analogues and Metabolites as Inhibitors of Wool and Hair Growth

Non-human Hair

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