Effects of intestinal flora on polycystic ovary syndrome

Liu, Jiayue; Liu, Ying; Li, Xiaoliang

doi:10.3389/fendo.2023.1151723

Cited by 7 publications

(8 citation statements)

References 94 publications

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“…Referring to the second issue, it has been shown that a decrease in HDL-C may be induced by increased expression of pro-inflammatory cytokines, i.e., those of the tumor necrosis factor-alpha (TNF-α) family [ 41 , 42 ]. Therefore, inflammatory diseases and an altered reproductive tract microbiome (as seen in endometriosis, pelvic inflammatory disease, or obesity-induced inflammation) and gut microbiota disturbances with many pro-inflammatory cytokines are taken into account as cofactors of ovary dysfunction [ 43 , 44 , 45 ]. With regard to the third issue, epigenetic studies have revealed that low HDL-C was the only metabolic marker significantly associated with epigenetic age acceleration (EAA) in mothers [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples

Wasilewski,

Wasilewska,

Łukaszewicz-Zając

et al. 2023

JCM

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Subfertility is a global health issue, and as many as 30% of cases are attributed to unexplained reasons. A hypercaloric, high-fat diet stimulates the expansion of pro-inflammatory gut microbiota with a consequent rise in circulating lipopolysaccharides. Adverse gut microbiota remodeling can exacerbate insulin resistance, while sex and thyroid hormones may influence the variability in gut microbiota. This cross-sectional study included 150 participants and was designed to determine a biochemical, nutritional-related pattern that may distinguish subfertile from fertile individuals and couples. A panel of 28 biomarkers was assessed. Four biochemical phenotypes of unexplained subfertility were found, including two metabolic and two immune, when assessed using binary logistic regression models. Two phenotypes were distinguished in women: cardio-metabolic with atherogenic dyslipidemia (LowHDL-cholesterol: OR = 10.9; p < 0.05) and autoimmune thyroid disorder (Highanti-thyroid-peroxidase: OR = 5.5; p < 0.05) and two in men: hepato-metabolic with elevated liver injury enzymes (HighHOMA-IR: OR = 6.1; p < 0.05) and immune type-2 response (HighIgE: OR = 6.4; p < 0.05). The chances of a couple’s subfertility rose with the number of laboratory components of metabolic syndrome in the couple (OR = 1.7; p < 0.05) and if at least one partner had an elevated total IgE level (>100 kU/L) (OR = 6.5; p < 0.05). This study found that unexplained subfertility may be accompanied by mutually overlapping immune and metabolic dysregulations in individuals and couples. We propose one-time laboratory diagnostics taking into account the lipid profile, insulin resistance, anti-thyroid-peroxidase, and total IgE in both males and females with unexplained subfertility. This may allow for a one-time assessment of targeted medical and nutritional interventions and help optimize patients’ health. The gut–organ axes related to subfertility are discussed in the context of the obtained results.

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Section: Discussionmentioning

confidence: 99%

Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples

Wasilewski,

Wasilewska,

Łukaszewicz-Zając

et al. 2023

JCM

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“…The correlation between GM and hormones regulation was also found to affect PCOS disease [40]. PCOS is a common endocrine disorder in women of reproductive age and its clinical features are mainly oligo-ovulation or anovulation, hyperandrogenemia and insulin resistance.…”

Section: Role Of the Gut Microbiome-estrogen Axis In Gynecological Di...mentioning

confidence: 90%

Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments

Martinelli,

Nannini,

Cianchi

et al. 2023

Microorganisms

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Fecal microbiota transplantation (FMT) is a procedure that involves transferring fecal bacteria from a healthy donor to a patients’ intestines to restore gut–immunity homeostasis. While FMT was primarily supposed to treat gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome—and especially Clostridium difficile infection (currently the only used as clinical treatment)—recent research has suggested that it may also become a potential treatment for gynecological disorders, including endometriosis and polycystic ovary syndrome (PCOS). On the contrary, vaginal microbiota transplantation (VMT) is a newer and less commonly used procedure than the FMT approach, and its potential applications are still being explored. It involves direct grafting of the entire vaginal microbiota of healthy women into the vaginal tract of patients to easily rebuild the local microbiota environment, restoring vaginal eubiosis and relieving symptoms. Like FMT, VMT is thought to have potential in treating different microbiota-related conditions. In fact, many gynecological disorders, such as bacterial vaginosis and vulvovaginal candidiasis, are thought to be caused by an imbalance in the vaginal microbiota. In this review, we will summarize the development, current challenges, and future perspectives of microbiota transplant, with the aim of exploring new strategies for its employment as a promising avenue for treating a broad range of gynecological diseases.

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“…The intestinal flora is related to the pathophysiological mechanisms of PCOS, including hyperandrogenism, insulin resistance, obesity, etc. [42,43] . By comparing the results obtained from PCOS animal models compared to the control group, it was found that hyperandrogenism causes a decrease in the species and number of bacteria in the large intestine of mice and can significantly change the intestinal flora, and the change in the intestinal flora can regulate the serum testosterone level [41,[44][45][46][47] .…”

Section: Intestinal Flora and Pcosmentioning

confidence: 99%

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

Rajabi,

Babaie,

Sadeghzadeh Oskouei

et al. 2023

Reproductive and Developmental Medicine

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Polycystic ovary syndrome (PCOS), a common endocrine disorder with metabolic and reproductive consequences, affects a significant percentage of women of reproductive age. Because of its complexity and impact on the quality of life, PCOS requires timely diagnosis and screening for complications. The most common clinical manifestations of PCOS are hirsutism, hyperandrogenism, acne, irregular cycles, amenorrhea, and anovulation. Although PCOS has different clinical manifestations in women, hyperandrogenism, and anovulation are the most common symptoms. A good medical history, examination, blood tests, and ultrasound findings facilitate the diagnosis of PCOS. Novel treatments have also undergone clinical trials to improve the symptoms of PCOS. However, comprehensive review articles investigating the different communities of this disease are limited, and this review aimed to collect data on the different etiologies of PCOS along with the latest diagnostic methods and the most common and up-to-date treatments for this disease.

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Effects of intestinal flora on polycystic ovary syndrome

Cited by 7 publications

References 94 publications

Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples

Subfertility as Overlapping of Nutritional, Endocrine, Immune, and Cardiometabolic Dysregulations—A Study Focused on Biochemical Endophenotypes of Subfertile Couples

Microbiota Transplant and Gynecological Disorders: The Bridge between Present and Future Treatments

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

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