Effects of Intra-Amygdalar Administration of GABAA Receptor Agonists and Antagonists on the Behavior of Active and Passive Rabbits in Emotionally Negative Situations

Differential Effect of Unilateral Amygdalar GABA<sub>A</sub> Receptor Agonist Injection on Low- and High-Anxiety Rats

“…Moreover, there literature data demonstrate lateralization of the effect anxiolytic drug on brain activity [42]- [44]. Earlier, in the experiments on rabbits we also observe the inequality of the effect of the GABA A receptor agonist upon introduction into the right and left amygdala, however, in contrast to rats, muscimol causes higher effect upon introduction in the right amygdala in passive rabbits, decreasing percent of freezing on loud sound [30]. Probably, the differences between the results of the current study and the literature data are due to differences in experimental conditions and the animals used.…”

Effects of Administration of an Agonist and an Antagonist of GABAA Receptors into the Basolateral Nucleus of the Amygdala on the Expression and Extinction of Fear in Rats with Different Freezing Durations

“…Substances were given sequentially into the right and left amygdala. Following to published data [Moghaddam et al, 2008;Rysakova and Pavlova, 2012;Laurent and Westbrook, 2008], muscimol hydrobromide (Sigma) was given at a dose of 0.1 μg/0.5 μl and bicuculline methiodide (Sigma) at the dose of 0.07 μg/0.5 μl, and physiological saline in a volume of 0.5 μl. The muscimol dose was the mean of published values for producing the anxiolytic effect and the minimum dose of bicuculline for obtaining the anxiogenic effect.…”

“…We have previously obtained data on the unequal infl uences of administration of GABA A receptor agonists and antagonists into the basolateral amygdala on behavior and autonomic expression of anxiety and fear in active and passive rabbits, identifi ed on the basis of movement and exploratory activity in the open fi eld and dark-light box [Rysakova and Pavlova, 2012;Pavlova and Rysakova, 2013]. Published data both support the relationship between the GABAergic system of the amygdala and differences in the manifestations of anxiety and fear [Kash et al, 1999;Lehner et al, 2010;Tasan et al, 2011] and refute it [Sienkiewicz-Jarosz et al, 2003].…”