Effects of Intra-Uterine Spirals and Hormones on the Uterine Histology of the Ovariectomized Goat

Abstract

Studies on the mechanism of action on intra-uterine foreign bodies are gaining importance in the field of reproductive biology. Doyle & Margolis (1963, 1964a, b) found in the rat that, following ovulation and fertilization, implantation did not occur in the threaded uterine horn due to a hostile uterine environment and interference with the normal decidual reaction. Buch, Shukla & Hawk (1964) showed that in the Surti water buffalo an intra-uterine polyethylene loop prevented ovulation. In cows, Hawk, Conley, Brinsfield & Righter (1964) observed that the loop acted as a contraceptive device within 3 days of breeding, possibly by interfering with one or more of the following processes: fertilization, cleavage, ovum transport and corpus luteum formation.The action of ovarian hormones on the histology of the uterus following ovariectomy has been studied by many workers. Among them, Cleveland (1941) studied the ovariectomized monkey and both Bell, Casida & Darlow (1941) and Ryle (1962) the ovariectomized ewe. Distinct morphological changes due to treatment with ovarian hormones in these species have been established. Oestrogens bring about cell proliferation and the combination of oestrogen and progesterone produces a secretory phase of the endometrium.A trial was performed with seven goats ovariectomized during anoestrus in order to observe the effects of intra-uterine polyethylene spirals, a combination of oestradiol-17\g=b\ and progesterone and their interactions on the histology of the goat uterus.

Inhibition by Aspirin and Indomethacin of Uterine Hypertrophy Induced by an Iud

“…The presence of an IUD in one horn of the uterus in rats (Parr & Segal, 1966;Parr, 1969;Saksena, Lau & Castracane, 1974), rabbits (Ledger & Bickley, 1966), hamsters (Saksena et al, 1974), and goats (Janakiraman, Shukla, Gadgil & Buch, 1966) has been shown to cause an increase in the weight ofthat horn when compared with that of the control horn. It has been suggested that such an increase in weight and uniform growth is due to chronic inflammation even though administration of hydrocortisone failed to suppress such a response (Parr & Segal, 1966).…”

The Role of Inflammation in the Uterine Weight Increase Caused by an Iud

“…An IUD in one horn of the uterus in rats (Parr & Segal, 1966), rabbits (Ledger & Bickley, 1966) and goats (Janakiraman, Shykla, Gadgil & Buch, 1966) caused an increase in the weight of that horn when compared to the control horn. An IUD probably also increased the weight of the human uterus (Dickin¬ son & Smith, 1913; Grafenberg, 1931;Israel & Davis, 1966).…”