Effects of intraarticular injection of halopredone diacetate on the articular cartilage of rabbit knees: A comparison with methylprednisolone acetate

Ishikawa, Kôichirô; Ohira, Takashi; Sakata, Hiroaki

doi:10.1016/0041-008x(84)90179-0

Cited by 14 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One rabbit model (5% human weight) studied 2 doses (1.4 and 7 mg) given weekly and found dose-dependent cystic lesions, fissuring, and cell death and decreased proteoglycan levels. 19 Another rabbit model (4% human weight) used 7 mg MPA administered in twice-weekly injections and similarly found increased cartilage erosions, decreased GAG content, and narrowing of joint spaces associated with MPA. 2 A primate knee model (9% human weight) was used to examine 1, 2, or 6 injections of 20 mg MPA over 12 weeks and found only minor, nonsignificant, dose-dependent deleterious effects of MPA on histochemical properties of cartilage in comparison with controls.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Intra-articular Corticosteroids on Articular Cartilage

Wernecke

Braun

Dragoo

2015

Orthopaedic Journal of Sports Medicine

296

221

View full text Add to dashboard Cite

Background:Intra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s.Purpose:To review the current literature on the effects of IA corticosteroids on articular cartilage.Study Design:Systematic review.Methods:A MEDLINE and SCOPUS database search was performed, and studies were selected for basic science and clinical trial research on corticosteroids with direct outcome measures of cartilage health. Preliminary searches yielded 1929 articles, and final analysis includes 40 studies.Results:Methylprednisolone, dexamethasone, hydrocortisone, betamethasone, prednisolone, and triamcinolone were reported to display dose-dependent deleterious effects on cartilage morphology, histology, and viability in both in vitro and in vivo models. The beneficial animal in vivo effects of methylprednisolone, hydrocortisone, and triamcinolone occurred at low doses (usually <2-3 mg/dose or 8-12 mg/cumulative total dose in vivo), at which increased cell growth and recovery from damage was observed; the single human clinical trial indicated a beneficial effect of triamcinolone. However, at higher doses (>3 mg/dose or 18-24 mg/cumulative total dose in vivo), corticosteroids were associated with significant gross cartilage damage and chondrocyte toxicity. Dose and time dependency of corticosteroid chondrotoxicity was supported in the in vitro results, however, without clear dose thresholds.Conclusion:Corticosteroids have a time- and dose-dependent effect on articular cartilage, with beneficial effects occurring at low doses and durations and detrimental effects at high doses and durations. Clinically, beneficial effects are supported for IA administration, but the lowest efficacious dose should be used.

show abstract

Section: Resultsmentioning

confidence: 99%

The Effect of Intra-articular Corticosteroids on Articular Cartilage

Wernecke

Braun

Dragoo

2015

Orthopaedic Journal of Sports Medicine

296

221

View full text Add to dashboard Cite

show abstract

“…Previous studies of animal models have suggested that repeated high doses of intra-articular corticosteroids can adversely affect articular cartilage. 7,22 In human studies, possible side effects of reduced tendon mechanical properties and increased bleeding have been associated with corticosteroid injections in the treatment of acute soft tissue injuries 29 ; however, little confirmatory evidence is available in human trials or when used intra-articularly at either lower doses or frequency after acute injury. 17,42 For these reasons, the available data supported our conclusion that short-term use of intra-articular corticosteroids after ACL injury would not place the patient at increased short-or long-term risk.…”

Section: Protocolmentioning

confidence: 99%

A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The ratio between m/z 237.12696 and m/z 375.19620 was always greater than 40 for dexamethasone and less than 0. 5…”

Section: It Was Always Less Than 1 For Dexamethasone and Greater Thanmentioning

confidence: 99%

“…Glucocorticoids are indispensable anti‐inflammatory and decongestant drugs with high prevalence of use . A wider holistic view on the effect of glucocorticoids inside the body is very crucial for its optimal utilization in concurrent medication and minimization of adverse effects . The adverse effects of corticosteroids are inherent by mode of actions, such as activation of the endogenous hormone and providing pathways for natural stress responses in fight‐or‐flight conditions .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] A wider holistic view on the effect of glucocorticoids inside the body is very crucial for its optimal utilization in concurrent medication and minimization of adverse effects. [5][6][7] The adverse effects of corticosteroids are inherent by mode of actions, such as activation of the endogenous hormone and providing pathways for natural stress responses in fight-or-flight conditions. [8][9][10] Although guidelines have been published for the controlled treatment with minimal adverse effects, [11][12][13] the said monitoring is often complicated, time consuming, and incur huge costs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mass spectrometric method for distinguishing isomers of dexamethasone via fragment mass ratio: An HRMS approach

et al. 2018

View full text Add to dashboard Cite

The major challenge in identifying dexamethasone, betamethasone, and paramethasone from a mixture of these corticosteroids is difficulty in achieving an efficient separation. In this study, we aimed to develop an efficient technique to identify these co-eluting isomers based on the mass spectral patterns of them and their corresponding phase II metabolites after electrospray ionization. Fragmentation pathways in tandem mass spectrometry revealed acceptable specificity within the groups of conjugates. The method was validated using individual isomers and mixtures at various compositions. The effects of concentration and collision energies on fragmentation patterns were also studied extensively. Matrix-fortified equine urine and plasma samples were also included so that matrix effects and interferences on fragmentation ratios could be elucidated. Preliminary results using biological samples demonstrated the suitability of this analytical strategy for direct measurement from their fragmentation patterns. Possible fragmentation pathways for each isomer were proposed.

show abstract

Effects of intraarticular injection of halopredone diacetate on the articular cartilage of rabbit knees: A comparison with methylprednisolone acetate

Cited by 14 publications

References 15 publications

The Effect of Intra-articular Corticosteroids on Articular Cartilage

The Effect of Intra-articular Corticosteroids on Articular Cartilage

A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear

Mass spectrometric method for distinguishing isomers of dexamethasone via fragment mass ratio: An HRMS approach

Contact Info

Product

Resources

About