Effects of intrabursal administration of botulinum toxin type B on lameness in horses with degenerative injury to the podotrochlear apparatus

Gutierrez‐Nibeyro, Santiago D.; Santos, Magda Guadalupe dos; White, Nathaniel A.; Brown, James A.; Adams, Martha; McKnight, Alexia L.; Schaeffer, David J.

doi:10.2460/ajvr.75.3.282

Cited by 6 publications

(3 citation statements)

References 49 publications

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“…Perineural anaesthesia of the digital nerves, intra‐articular analgesia of the distal interphalangeal (DIP) joint or intrabursal analgesia of the navicular bursa are used to identify the origin of foot pain (Turner, ). Administration of corticosteroid and hyaluronate into synovial cavities, including the navicular bursa, is sometimes used in the treatment of chronic palmar foot pain (Dabareiner et al., ; Bell et al., ; Boyce et al., ; Gutierrez‐Nibeyro et al., ).…”

Section: Introductionmentioning

confidence: 99%

Ex VivoAssessment of an Ultrasound-Guided Injection Technique of the Navicular Bursa in the Horse

Perrin

Diguet

Cantet

et al. 2015

Anat. Histol. Embryol.

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Synovitis of the navicular bursa is common in performance horses. The objective of this study was to describe an ultrasound-guided technique to inject a distended navicular bursa and to evaluate its feasibility for use by a clinician not trained in the technique. Twenty distal limbs of horses of various breeds and sizes were used. To produce synovial distension, the navicular bursa of each limb was injected with contrast medium using a lateral approach and radiography was performed to confirm that the contrast medium was distending the bursa. The digit was positioned with the distal interphalangeal joint in hyperextension. A microconvex ultrasound probe was placed in the hollow of the pastern, palmar to the middle phalanx and the region was assessed in a transverse plane slightly oblique to the horizontal plane. The ultrasound probe was rotated to visualize both the lateral and medial recesses and to select which side was more distended to inject. A 21G 0.8 × 50 mm needle was inserted abaxially to the probe in the plane of the ultrasound beam into the proximal recess of this navicular bursa and a methylene blue solution was injected. Following injection, dissection was performed to assess whether the navicular bursa had been successfully injected. This ultrasound-guided technique was reliably performed with a success rate of 68%. The success of injection is influenced by hyperextension of the foot, quality of ultrasound images and degree of distension of the bursa.

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Section: Introductionmentioning

confidence: 99%

Ex VivoAssessment of an Ultrasound-Guided Injection Technique of the Navicular Bursa in the Horse

Perrin

Diguet

Cantet

et al. 2015

Anat. Histol. Embryol.

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“…However, a total lameness-free condition was not achieved. Multiple injections or higher BoNT-B doses/concentrations/volumes may be needed to optimize the analgesic effect before the clinical application can be recommended in horses [ 39 ].…”

Section: Therapeutic Applications In Veterinary Medicinementioning

confidence: 99%

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Turin,

Piccione,

Crosa

et al. 2023

Veterinary Sciences

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Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds for the treatment of several different syndromes involving peripheral and central nervous systems, and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the study of BoNTs is rapidly developing and identifying newly produced BoNT variants. Efforts should be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes lies in its ability to reach a specific cell type while bypassing other cells, thus having mild or no side effects. In this paper the recent developments in BoNTs are reviewed with the aim of analyzing the current knowledge on BoNTs’ biological mechanisms of action, immunogenicity, formulations, and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and identifying the gaps to be filled in order to address research priorities.

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“…However, a total lameness-free condition was not achieved. Multiple injections or higher BoNT-B doses/concentrations/volumes may be needed to optimize the analgesic effect before clinical application can be recommended in horses [38].…”

Section: Horsementioning

confidence: 99%

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Turin,

Piccione,

Crosa

et al. 2023

Preprint

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Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds for the treatment of several different syndromes involving peripheral and central nervous systems, and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the studies of BoNTs are rapidly developing and identifying newly produced BoNT variants. Efforts should be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes lies on its ability to reach a specific cell type bypassing other cells, thus having mild or no side effects. In this paper the recent developments on BoNTs are reviewed with the aim to analyze the current knowledge on BoNTs biological mechanisms of action, immunogenicity, formulations, and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and identifying the gaps to be filled in order to address research priorities.

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Effects of intrabursal administration of botulinum toxin type B on lameness in horses with degenerative injury to the podotrochlear apparatus

Abstract: Intrabursal injection of BTXB temporarily alleviated chronic lameness in horses with degenerative injury to the PA, without causing serious short-term adverse effects. Further investigation into the potential use of BTXB in horses affected by degenerative injury to the PA is warranted.

Cited by 6 publications

References 49 publications

Ex VivoAssessment of an Ultrasound-Guided Injection Technique of the Navicular Bursa in the Horse

Ex VivoAssessment of an Ultrasound-Guided Injection Technique of the Navicular Bursa in the Horse

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

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