Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

Kuhla, Björn; Ackern, Isabel van

doi:10.3168/jdsc.2021-0185

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…In rodents and cows, AEA administrations either increased or did not affect short-term feed intake 14 , 16 , 31 , 53 , but there are no previous studies reporting a decrease in short-term feed intake in mammals. Here we report that long-term administration of AEA decreases feed intake of cows after 4 weeks of treatment.…”

Section: Discussionmentioning

confidence: 91%

“…AEA administration to late-lactating cows 15 . However, a reduction in milk yield after intracerebroventricular injection was observed in mid- and late-lactating cows 16 .…”

Section: Discussionmentioning

confidence: 92%

“…The best-characterized endocannabinoid AEA is known to exert orexigenic effects. Peripheral and central administration of AEA increases short-term feed intake of mid- and late-lactating cows 14 – 16 . Furthermore, AEA is involved in the regulation of fat metabolism.…”

Section: Introductionmentioning

confidence: 99%

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The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

Schwerdtfeger,

Sauerwein,

Albrecht

et al. 2023

Sci Rep

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The aim of the study was to investigate the effect of N-arachidonoylethanolamide (AEA), an endocannabinoid with orexigenic characteristics, on plasma endocannabinoid concentrations, feed intake, energy balance, lipomobilisation, and hepatic lipid metabolism of early-lactating dairy cows. The experiment involved 10 pairs of Holstein half-sibling cows (end of 2nd–3rd pregnancy). Half-sibs of each pair were randomly assigned to either AEA (n = 10) or control (CON) group (n = 10). From day 1 to 30 postpartum, the AEA group received 5 intraperitoneal injections per week of 3 µg/kg body weight AEA and the CON group 0.9% NaCl. In week 1–3 postpartum, AEA administration had no effect on dry matter intake, body weight, or lipomobilisation, but increased plasma triglyceride concentration on d 21 p.p. and mRNA abundances of genes related to hepatic triglyceride synthesis. In week 4 postpartum, the AEA group showed reduced feed intake and whole-body carbohydrate oxidation, but increased whole-body fat oxidation and hepatic lipid accumulation, likely as a result of a counter-regulatory leptin increase. In conclusion, the present study shows a tissue-specific AEA insensitivity and may point to a leptin-controlled regulation of the ECS in early-lactation.

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Section: Discussionmentioning

confidence: 91%

“…AEA administration to late-lactating cows 15 . However, a reduction in milk yield after intracerebroventricular injection was observed in mid- and late-lactating cows 16 .…”

Section: Discussionmentioning

confidence: 92%

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The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

Schwerdtfeger,

Sauerwein,

Albrecht

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

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The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

Schwerdtfeger¹,

Sauerwein

Albrecht³

et al. 2023

Preprint

Self Cite

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The endocannabinoid system (ECS) is involved in the regulation of fat and energy metabolism, but knowledge about its influence in early lactation of cows is scarce. The aim of the study was to investigate the effect of N-arachidonoylethanolamide (AEA), an endocannabinoid with orexigenic characteristics, on plasma endocannabinoid concentrations, feed intake, energy balance, lipomobilisation, and hepatic lipid metabolism of early-lactating dairy cows. The experiment involved 10 pairs of Holstein half-sibling cows (end of 2nd -3rd pregnancy). Half-sibs of each pair were randomly assigned to either AEA (n = 10) or control (CON) group (n = 10). The AEA group received repeated intraperitoneal injections of 3 µg/kg body weight AEA and the CON group 0.9% NaCl. In week 1 to 3 postpartum, AEA administration had no effect on dry matter intake, body weight, or lipomobilisation, but affected plasma triglyceride concentration and mRNA abundances of genes related to hepatic triglyceride synthesis. In week 4 postpartum, the AEA group showed reduced feed intake and whole-body carbohydrate oxidation, but increased whole-body fat oxidation and hepatic lipid accumulation, likely as a result of a counter-regulatory leptin increase. In conclusion, the present study shows a tissue-specific AEA insensitivity and may point to a leptin-controlled regulation of the ECS in early-lactation.

show abstract

Effects of intracerebroventricular anandamide administration on feed intake and milk yield of dairy cows

Cited by 2 publications

References 17 publications

The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows

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