Effects of intracerebroventricular calcitonin in the conscious rabbit

Pecile, A.; Ferri, Sergio Solbes; Braga, P. C.; Olgiati, Vincenzo R.

doi:10.1007/bf01922569

Cited by 173 publications

(26 citation statements)

References 2 publications

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“…Intracerebroventricular but not intravenous injections of CT stimulated prolactin secretion in rats (38). Furthermore, intracerebroventricular administration of CT resulted in analgesia and blocking of evoked potentials to painful stimuli, an effect which was not suppressed by the opiate antagonist naloxone (39)(40)(41). In rat brain membranes (21) and human brain homogenates, naloxone and morphine failed to inhibit`2I-CT binding.…”

Section: Discussionmentioning

confidence: 97%

Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.

Fischer¹,

Tobler²,

Kaufmann³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

174

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Immunoreactive calcitonin (CT), indistinguishable from human CT-(1-32) and its sulfoxide, has been identified in extracts of the hypothalamus, the pituitary, and the thyroid obtained from human subjects at autopsy. CT concentrations were highest in a region encompassing the posterior hypothalamus, the median eminence, and the pituitary; intermediate in the substantia nigra, the anterior hypothalamus, the globus pallidus, and the inferior colliculus; and low in the caudate nucleus, the hippocampus, the amygdala, and the cerebral and cerebellar cortices. Specific CT binding measured with "MI-labeled salmon CT was high-

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Section: Discussionmentioning

confidence: 97%

Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.

Fischer¹,

Tobler²,

Kaufmann³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

174

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“…Pecile and co-workers in 1975 showed that icv injection of single doses of SCT increased the pain threshold of rabbits to electrical stimulation of the pulp of the upper incisors, manifested as licking [26]. The analgesia had a relatively rapid onset (approximately 20 min) and increased to a plateau at 90 min that persisted until the end of the 120 min experiment.…”

Section: The Analgesic Action Of Calcitonin In Animal Modelsmentioning

confidence: 98%

“…One study has shown that SCT may be more effective in patients with high bone turnover [26]. Despite being associated with a significant reduction in the risk of new vertebral fractures, SCT is associated with modest increases in lumbar bone mineral density (BMD) and modest decreases in bone turnover, suggesting that calcitonin may reduce vertebral fracture risk by other mechanisms such as improving bone quality [22].…”

Section: Introductionmentioning

confidence: 99%

The Analgesic Role of Calcitonin Following Osteoporotic Fracture

Silverman

Azria

2002

Osteoporosis International

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Osteoporosis is a systemic skeletal condition characterized by decreased bone strength with consequent increased susceptibility to bone fracture. Fragility fractures in osteoporosis are often painful and result in loss of quality of life and disability. Salmon calcitonin (SCT) is a natural hormone that may assist in the management of osteoporotic patients following fracture by reducing fracture risk and decreasing pain. SCT is an antiresorptive agent which has been shown to reduce the risk of vertebral fractures (by 36%) in postmenopausal women with osteoporosis and previous fractures, with a safety profile comparable to placebo over long-term use. Clinical evidence suggests that SCT (with either subcutaneous and intranasal delivery) is an analgesic for the acute pain following osteoporotic fracture. Pain relief with SCT occurs after 1 week or less of treatment. Associated with this pain relief, vertebral fracture patients receiving SCT have been observed to have earlier mobilization compared with those receiving a placebo. Both preclinical and clinical data suggest a central analgesic effect for SCT. The mechanism(s) by which SCT induces pain relief has (have) not been conclusively shown. Neither a direct receptor-mediated action nor an indirect endorphin-mediated effect can be ruled out.

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“…Calcitonin, discovered in 1961, has been established, synthesized, and developed for use in treating disease 6 . In 1983 it was demonstrated that calcitonin is an analgesic, 7 which is also effective in the epidural and subarachnoid spaces 8‐11 …”

Section: Introductionmentioning

confidence: 99%

Epidural Calcitonin: Does it Provide Better Postoperative Analgesia? An Analysis of the Haemodynamic, Endocrine, and Nociceptive Responses of Salmon Calcitonin and Opioids in Epidural Anesthesia for Hip Arthroplasty Surgery

Gabopoulou¹,

Vadalouca²,

Velmachou³

et al. 2002

Pain Practice

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Calcitonin is an endogenous regulator of calcium homeostasis, which acts principally on bone. At present, the principal indications for the therapeutic use of calcitonin are disorders involving hypercalcemia Paget's disease, acute pancreatitis, high-bone-turnover osteoporosis, pain associated with osteoporosis or bone metastases, and Sudeck's atrophy. The aim of this study was to compare the analgesic effects on postoperative pain of salmon calcitonin versus opioids administered epidurally. Our prospective study included 53 ASA I-II patients who were scheduled for total hip arthoplasty under epidural anaesthesia and who did not fulfill 1 or more of the exclusion criteria: a history of pituitary gland dysfunction; diabetes mellitus; obesity; contraindications to performing an epidural block and/or an allergy to calcitonin. These patients were randomly allocated into 3 groups (A, B, and C), each of which received postoperatively a different analgesic epidural mixture of 10 mL to control postoperative pain. Group A was given bupivacaine 0.5% (5 mL) + fentanyl 100 (2 mL) + NaCl 0.9% (3 mL). Group B was given bupivacaine 0.5% (5 mL) + salmon calcitonin 100IU (1 mL) + NaCl 0.9% (4 mL). Group C was given salmon calcitonin 100IU (1 mL) + NaCl 0.9% (9 mL). Perioperatively, 4 blood samples were taken from each patient at the following specific times: 1. Before the induction of anesthesia; 2. At the end of the operation and before the epidural administration of the analgesic mixture; 3. At the end of the first postoperative hour (1 hour after the administration of the analgesic mixture); and 4. At the end of the second postoperative hour (2 hours after the administration of the mixture). In each blood sample, glucose, cortisol, growth hormone, and prolactin plasma levels were determined in order to investigate the changes of these parameters as a result of the endocrine reaction to stress, and to pain relief. The analgesic solution was administered immediately after the second blood sample was taken. At the same time as the 4 blood samples were taken, haemodynamic parameters and pain scores were recorded. Epidural salmon calcitonin in combination with local anaesthetic produces an analgesic effect similar to fentanyl and with stable hemodynamic results. It also eliminates postoperative hyperglycaemia. The cortisol plasma level does not increase during the first postoperative hour, but increases significantly during the second postoperative hour. Growth hormone and prolactin plasma levels were stable in all patients in all 3 groups. This study shows that calcitonin is a suitable alternative for the treatment of acute postoperative pain.

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Effects of intracerebroventricular calcitonin in the conscious rabbit

Cited by 173 publications

References 2 publications

Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.

Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.

The Analgesic Role of Calcitonin Following Osteoporotic Fracture

Epidural Calcitonin: Does it Provide Better Postoperative Analgesia? An Analysis of the Haemodynamic, Endocrine, and Nociceptive Responses of Salmon Calcitonin and Opioids in Epidural Anesthesia for Hip Arthroplasty Surgery

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