Effects of intracervical prostaglandin E2 on fetal heart rate and uterine activity patterns in the presence of oligohydramnios

Larson, Janet D.; Rayburn, William F.; Turnbull, Gayla L.; Schwartz, William J.; Stanley, John R.; Christensen, H.Dix

doi:10.1016/0002-9378(95)91346-7

Cited by 12 publications

(10 citation statements)

References 5 publications

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“…The one case of neonatal acidosis that was recorded in each group was not a significant finding. Our results are in accordance with those of Larson et al [17].…”

Section: Discussionsupporting

confidence: 83%

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Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Stefos¹,

Mouzakioti²,

Sotiriadis³

et al. 2000

Gynecol Obstet Invest

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The effectiveness of intracervical prostaglandin E2 (PGE2) was studied in 96 primigravidas with unfavorable cervix and need for induction of labor. Group A consisted of 49 oligohydramnios and group B of 47 cases with normal amniotic fluid volume (controls). A single dose of 0.5 mg PGE2 gel was applied intracervically and several parameters were recorded during the next hours. The mean number of uterine contractions increased during the first 2 h in both groups, decreased during the next one and did not change significantly afterwards. The mean fetal heart rate (FHR) in group A decreased during the first 2 h and then increased, staying always within normal limits. The mean FHR in group B increased for 2 h, decreased during the next hour and did not change significantly afterwards. No significant differences were found between the two groups regarding mode of delivery, Apgar score and neonatal acidosis. Intracervical PGE2 appeared to effectively stimulate cervical ripening and labor induction in oligohydramnios, without causing side effects to the uterus and fetus.

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“…The one case of neonatal acidosis that was recorded in each group was not a significant finding. Our results are in accordance with those of Larson et al [17].…”

Section: Discussionsupporting

confidence: 83%

“…So, the intracervical use of PGE2 is safe, as previous studies have also revealed [9,13,[17][18][19]. In addition, the first 2 h after PGE2 application are considered to be the most important, because FHR decelerations with no longterm adverse effects are recorded during this time interval.…”

Section: Discussionmentioning

confidence: 88%

Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Stefos¹,

Mouzakioti²,

Sotiriadis³

et al. 2000

Gynecol Obstet Invest

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“…16,17 In agreement with our results, a recently published study comparing the use of a double-balloon catheter and PGE2 for induction of labor in term patients with oligohydramnios, did not find any differences in cesarean delivery rates or in change of Bishop scores. However, they found an increased number of newborns with umbilical cord arterial blood pHo 7.1 when PGE2 was used to induce labor.…”

Section: Discussionsupporting

confidence: 95%

Intra-vaginal prostaglandin E2 versus double-balloon catheter for labor induction in term oligohydramnios

et al. 2014

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“…Although there are studies testing the safety and efficacy of different prostaglandin preparations such as prostaglandin E 2 for labor induction in cases with oligohydramnios [12,13], currently there is no study in the literature focusing on the efficacy and safety of misoprostol for cervical ripening and labor induction in oligohydramniotic patients. Data on the effectiveness of misoprostol are promising [7].…”

Section: Discussionmentioning

confidence: 99%

Misoprostol for Cervical Ripening and Labor Induction in Pregnancies with Oligohydramnios

Dede¹,

Haberal²,

Dede³

et al. 2004

Gynecol Obstet Invest

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The efficacy and safety of misoprostol for cervical ripening and labor induction in patients with oligohydramnios was investigated. 57 pregnancies with oligohydramnios and 58 cases with a normal amniotic fluid volume (controls) were enrolled in this prospective trial. All patients received 50 µg of intravaginal misoprostol every 5 h. Primary outcomes were: cesarean section rate; induction to delivery time; oxytocin augmentation; uterine hyperstimulation; meconium passage; fetal heart rate (FHR) changes; fetal distress requiring delivery, and Apgar scores. There were no differences in the mean time to delivery, cesarean section rate, oxytocin augmentation or Apgar scores. The mean induction to delivery time in oligohydramnios and control groups were, 11 h 43 min and 11 h 18 min, respectively (p > 0.05). FHR changes were observed in 26.3% of oligohydramnios group and 32.7% of control group (p > 0.05). There was no statistically significant difference in the cesarean section rate and the uterine hyperstimulation between the 2 groups. These data suggest that misoprostol can be used as an effective agent for cervical ripening and labor induction in pregnancies with oligohydramnios without increasing the risk for perinatal outcome, compared to those with normal amniotic fluid volumes.

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Effects of intracervical prostaglandin E2 on fetal heart rate and uterine activity patterns in the presence of oligohydramnios

Cited by 12 publications

References 5 publications

Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Use of Prostaglandin E2 for Cervical Ripening in Pregnancies with Oligohydramnios

Intra-vaginal prostaglandin E2 versus double-balloon catheter for labor induction in term oligohydramnios

Misoprostol for Cervical Ripening and Labor Induction in Pregnancies with Oligohydramnios

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