Effects of intracoronary calcium chloride on regional oxygen balance and mechanical function in normal and stunned myocardium in dogs

Yoo, Kyung Yeon; Lee, J. U.; Kwak, Sang Hyun; Im, Woong Mo; Jeong, Chul; Chung, Seung Min; Yoon, Myung Ha; Jeong, Seong‐Jun; Park, J. T.

doi:10.1093/bja/88.1.78

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…In addition, volatile anesthetics have been shown to directly produce coronary vasodilation in vivo (27). However, it has been demonstrated that responses to inotropic drugs under halothane anesthesia do not differ from those under fentanyl-midazolam anesthesia in postischemic myocardium in dogs (28). Second, in the present study, inotropic drugs were administered before and after LAD occlusion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Inotropic Drugs on Mechanical Function and Oxygen Balance in Postischemic Canine Myocardium: Comparison of Dobutamine, Epinephrine, Amrinone, and Calcium Chloride

et al. 2005

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Brief ischemic episodes that induce myocardial and coronary endothelial dysfunction may alter the responses to inotropic drugs. To determine the effects of inotropic drugs in stunned myocardium, the coronary blood flow (CBF), myocardial oxygen consumption (MVO2), and regional mechanical function in response to intracoronary dobutamine, epinephrine, amrinone, and calcium chloride (CaCl2) were measured before (normal) and 30 min after a 15-min-period occlusion of the left anterior descending artery (stunned) in an open-chest canine model. Percent segment shortening (%SS) and post-systolic shortening (%PSS) were determined. Myocardial extraction of oxygen (EO2) and lactate (Elac) was calculated. The inotropic drugs increased %SS, CBF, and MVO2 in normal myocardium. Epinephrine and amrinone decreased, while dobutamine and CaCl2 did not affect EO2. The ischemia and reperfusion itself significantly reduced %SS and Elac, and increased %PSS. In stunned myocardium, the responses to inotropic drugs were not significantly altered, except that they progressively reduced %PSS and epinephrine did not affect EO2. These findings indicate that a brief episode of ischemia does not affect the mechanical and metabolic coronary flow responses to inotropic drugs, although it abolishes direct vasodilator responses to epinephrine.

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Section: Discussionmentioning

confidence: 99%

Effects of Inotropic Drugs on Mechanical Function and Oxygen Balance in Postischemic Canine Myocardium: Comparison of Dobutamine, Epinephrine, Amrinone, and Calcium Chloride

et al. 2005

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Quantification of regional myocardial blood flow in a canine model of stunned and infarcted myocardium: comparison of rubidium-82 positron emission tomography with microspheres

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deKemp

Beanlands

et al. 2010

Nuclear Medicine Communications

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Effects of Amrinone on Regional Myocardial Function and Oxygen Balance in Stunned Myocardium in Dogs

Yoo

Kim

Jeong

et al. 2002

Korean J Anesthesiol

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Effects of intracoronary calcium chloride on regional oxygen balance and mechanical function in normal and stunned myocardium in dogs

Abstract: These data suggest that calcium chloride improves regional systolic and diastolic function both in normal and stunned myocardium. Calcium chloride is unlikely to cause direct coronary vasoconstriction or to deteriorate regional mechanical function in postischaemic myocardium.

Cited by 5 publications

References 37 publications

Effects of Inotropic Drugs on Mechanical Function and Oxygen Balance in Postischemic Canine Myocardium: Comparison of Dobutamine, Epinephrine, Amrinone, and Calcium Chloride

Effects of Inotropic Drugs on Mechanical Function and Oxygen Balance in Postischemic Canine Myocardium: Comparison of Dobutamine, Epinephrine, Amrinone, and Calcium Chloride

Quantification of regional myocardial blood flow in a canine model of stunned and infarcted myocardium: comparison of rubidium-82 positron emission tomography with microspheres

Effects of Amrinone on Regional Myocardial Function and Oxygen Balance in Stunned Myocardium in Dogs

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