BackgroundMaintenance hemodialysis (MHD) patients is the representative of the sedentary group and often suffer from physical inactivity. Exercise rehabilitation is not widely included in dialysis care despite demonstrated health benefits. This study aimed to evaluate the effectiveness of intradialytic group exercise in MHD patients.MethodsThis was a single center, single-group repeated-measures design study, which included MHD patients in the hemodialysis center in Taizhou, China. The 12-week, 3 times per week intradialytic group exercise programme was conducted around 30 min during the first 2 hours of each dialysis session. Anthropometric indicators, including Body Mass Index (BMI), Triceps Skinfold Thickness (TSF), Mid-upper Arm Circumference (MUAC), Mid-arm Muscle Circumference (MAMC) Handgrip Strength (HGS), and quality of life were measured at baseline, 4-week follow up and 12-week follow up. Laboratory indicators, including Hemoglobin level (Hb), Total Protein (TP) and Albumin (Alb) were measured at baseline and 12-week follow up. The repeated-measures analysis of variance and Friedman test were used to compare the parametric and non‐parametric data at three time points, respectively. Paired t test was used to compare the continuous parametric between two time points.ResultsNinety patients were enrolled at baseline and seventy-five patients finished the whole 12-week exercise programme. There were 7 patients dropped out for losing of motivation and sample churn rate for losing of motivation was 7.8% (7/90). Participants reported significant improvements in most of the outcomes, TSF (F (2, 148) = 28.908, p = 0.000), MUMC (F (2, 148) = 3.1821, p = 0.044), MAMC (F (2, 148) = 27.795, p = 0.000), HGS (F (2, 148) = 42.383, p = 0.000), TP (F (t = -2.417, p = 0.018), ALB (t -3.190, p = 0.002), Hb (t = -2.353, p = 0.021), and QOL (F (2, 148) = 10.48, p = 0.000).ConclusionsThe positive results from this research suggest that intradialytic group exercise programme including aerobic exercise and resistance exercise is a safe and suitable exercise way for maintenance hemodialysis patients. This exercise can help keep patients’ motivation and improve nutritional status and quality of life in maintenance hemodialysis patients.