Effects of intragastric administration of La&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt; nanoparticles on mouse testes

Lei, Yuan; Bai, Disi; Meng, Lingjun; Wang, Hong; Sun, Zhaoyu; An, Tianyang; Chen, Zhenfei; Deng, Xuenan; Zhang, Xiujun

doi:10.2131/jts.45.411

Cited by 10 publications

(4 citation statements)

References 46 publications

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“…Numerous studies have demonstrated that NPs such as graphene, 32 SiO 2 -NPs, 33 Ag-NPs, 23 ZnO-NPs, 24 and La 2 O 3 -NPs 34 can significantly decrease the occludin protein level and increase the paracellular permeability in various biological barriers. In many of these studies, NPs were exposed at high doses or for extended periods, resulting in severe global cytotoxicity.…”

Section: Nanoparticles Interact With the "Gatekeepers" To Regulate Pa...mentioning

confidence: 99%

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

Zhu

Liu

et al. 2022

ACS Nano

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Biological barriers are essential physiological protective systems and obstacles to drug delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either causing adverse health impacts on humans or producing therapeutic opportunities. This Review introduces the structural and functional influences of NPs on the key components that govern the paracellular route, mainly tight junctions, adherens junctions, and cytoskeletons. Furthermore, we evaluate their interaction mechanisms and address the influencing factors that determine the ability of NPs to open the paracellular route, which provides a better knowledge of how NPs can open the paracellular route in a safer and more controllable way. Finally, we summarize limitations in the research models and methodologies of the existing research in the field and provide future research direction. This Review demonstrates the in-depth causes for the reversible opening or destruction of the integrity of barriers generated by NPs; more importantly, it contributes insights into the design of NP-based medications to boost paracellular drug delivery efficiency.

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Section: Nanoparticles Interact With the "Gatekeepers" To Regulate Pa...mentioning

confidence: 99%

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

Zhu

Liu

et al. 2022

ACS Nano

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“…It has been shown that cerium oxide nanoparticles (CeO 2 NPs) increase the amount of Ce in mouse testes, causing pathological damage to testicular tissue and reduced sperm viability and survival [ 5 ]. Lanthanum oxide (La 2 O 3 ) nanoparticles (NPs) are distributed in mouse testes and cross the blood–testis barrier, causing apoptosis of mouse spermatogenic cells [ 6 , 16 ]. Nd 2 O 3 enters the body mainly in the form of dust or aerosols through the respiratory tract and then travels through the bloodstream to cause damage to various organs, of which the male reproductive organs are more sensitive than other organs.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that rare earth cerium oxide particles (CeO 2 NPs) can increase the content of Ce element in mouse testis, cause pathological damage to testicular tissue, and reduce sperm viability and survival rate [ 5 ]. Other studies also show that rare earth lanthanum oxide particles (La 2 O 3 NPs) penetrate the blood–testis barrier of mice and accumulate in testicular tissue to cause apoptosis of spermatogenic cells [ 6 ]. However, the underlying mechanisms of reproductive damage have not been explicitly elucidated.…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq Analysis of Testes from Mice Exposed to Neodymium Oxide

Wang,

Bu,

Yun

et al. 2023

Toxics

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(1) Objective: Rare earth neodymium oxide (Nd2O3) is refined and used extensively around the world, and the occupational and environmental safety of rare piles of the earth has attracted considerable attention. Nd2O3 enters the human body through the respiratory system, reaches various organs through blood circulation, and accumulates to produce toxic effects. At present, little is known about the reproductive toxicity of Nd2O3. Non-coding RNAs participate in a variety of physiological activities and are very important for spermatogenesis. However, it is unknown whether they are involved in Nd2O3-induced reproductive toxicity. Therefore, we conducted a pathological analysis, sperm quality testing, and RNA-seq on the testicular tissue of mice exposed to Nd2O3 to find the key genes and regulatory pathways of male reproductive damage and explore the early biomarkers and mechanisms of reproductive damage caused by Nd2O3. (2) Methods: After exposure of mice to Nd2O3, we carried out a pathological analysis and RNA-seq analysis for miRNAs/lncRNAs/circRNAs/mRNAs on the testicular tissue of mice, and the total RNAs were used to investigate miRNA/lncRNA/circRNA/mRNA expression profiles by strand-specific RNA sequencing at the transcriptome level to help uncover RNA-related mechanisms in Nd2O3-induced toxicity. (3) Results: Nd2O3 damaged testis and sperm morphology, significantly decreased the number of sperm, and deformed the sperm head and tail. RNA-seq analysis showed that the expression level of mRNA/miRNA/circRNA/lncRNA in the testicular tissue of mice exposed to Nd2O3 is abnormal. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis demonstrated that the functional enrichment of differentially expressed genes (DEGs) and their target genes was closely related to the related pathway of spermatogenesis. Furthermore, some miRNAs/lncRNAs/circRNAs that were greatly upregulated or inducibly expressed, implying their potential value as candidate markers for Nd2O3-induced reproductive toxicity, help us to further investigate the mechanisms of key genes, key signaling pathways, and inter-gene regulation for Nd2O3-induced reproductive toxicity. (4) Conclusions: This study provides the first database of a Nd2O3-induced transcriptome. This information is useful for the development of biomarkers of Nd2O3-induced reproductive injury and promotes understanding of the reproductive toxicity mechanism of Nd2O3.

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“…The increased malondialdehyde and 8-OHdG activity and decreased SOD activity indicate that oxidative DNA damage may occur early after La 2 O 3 NPs exposure. 15 Yuan et al 15 has reported oxidative stress-mediated inflammation in toxicity of La NPs on the testicular cells. Angiotensin II has a detrimental role in the pathogenesis of chronic liver disease through possessing pro-oxidant, fibro genic, and pro-inflammatory impact in the liver.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells

et al. 2022

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Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La2O3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La2O3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La2O3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La2O3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La2O3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La2O3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La2O3 NPs over 48 hrs. Thus, study warrants the application of La2O3 NPs in daily life and provides vital information about the toxicity of La2O3 NPs.

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Effects of intragastric administration of La<sub>2</sub>O<sub>3</sub> nanoparticles on mouse testes

Cited by 10 publications

References 46 publications

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects

RNA-Seq Analysis of Testes from Mice Exposed to Neodymium Oxide

Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells

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