2017
DOI: 10.7897/2230-8407.08014
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Effects of Intramuscular Diclofenac Use on Lipid Peroxidation and Skeletal Muscle Histology in Balb-C Mice

Abstract: Diclofenac is a nonsteroidal anti-inflammatory drug that is widely used for the treatment of musculoskeletal complaints, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute muscle pain conditions. There is considerable interest in the toxicity of diclofenac because of its clinical uses. In the present study, the sub-chronic administration of diclofenac (10 mg/kg body weight; 30 days) resulted in various changes in activity of SOD enzyme (a marker of oxidative stress) and lipid peroxidation l… Show more

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