Effects of intranasal oxytocin on pain perception among human subjects: A systematic literature review and meta-analysis

Lopes, Samuel; Osório, Flávia de Lima

doi:10.1016/j.yhbeh.2022.105282

Cited by 8 publications

(1 citation statement)

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“…A recent meta-analysis examined the effects of intranasal oxytocin (OT IN ) on selfperception of pain across 15 studies [14]. Results indicated that while some individual studies reported significant differences in pain perception, the overall findings yielded no significant statistical effects of OT IN compared to placebo regarding subjective ratings of pain intensity or unpleasantness, pain threshold, or pain tolerance.…”

Section: Introduction 1oxytocin and Painmentioning

confidence: 99%

Intranasal Oxytocin and Pain Reduction: Testing a Social Cognitive Mediation Model

Long,

Scholl,

Wang

et al. 2023

Brain Sciences

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Oxytocin is well known for its role in relationships and social cognition and has more recently been implicated in pain relief and pain perception. Connections between prosocial feelings and pain relief are also well documented; however, the effects of exogenous oxytocin on social cognition and pain have not been explored. The current study tested whether intranasally delivered oxytocin affects pain perception through prosocial behaviors. Additionally, moderation of the effects of oxytocin by life history or genetic polymorphisms is examined. Young adults (n = 43; 65% female) were administered intranasal oxytocin (24 IU) or placebo in a crossover design on two visits separated by a one-week washout period. Pain was delivered via cold pressor. Baseline measures for decision-making and social cognition were collected, as well as pain sensitivity and medication history. Saliva samples were collected for analysis of genetic markers, and urine samples were collected to assess oxytocin saturation. Following oxytocin administration, participants reported increased prosocial cognition and decision-making. Pain perception appeared to be adaptive, with procedural order and expectation affecting perception. Finally, behavioral trust and cooperation responses were significantly predicted by genetic markers. Oxytocin may increase a patient’s trust and cooperation and reduce pain sensitivity while having fewer physiological side effects than current pharmaceutical options.

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Section: Introduction 1oxytocin and Painmentioning

confidence: 99%