Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats

Sugaya, Kimio; Nishijima, Saori; Miyazato, Minoru; Ashitomi, Katsuhiro; Hatano, Tadashi; Ogawa, Yoshihide

doi:10.1016/s0304-3940(02)00459-7

Cited by 94 publications

(84 citation statements)

References 9 publications

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“…In our previous study, intrathecal injection of tamsulosin or naftopidil (alpha-1a or -1d adrenergic receptor antagonists, respectively) at the lumbosacral level of the spinal cord prolonged the interval between isovolumetric bladder contractions in rats. 13 This effect of naftopidil has also been recognized in rats with chronic spinal cord injury (SCI). 14 Since there are noradrenergic projections to the spinal cord from the brainstem, 15 the effect of naftopidil in SCI rats suggests that circulating catecholamines may act on the lumbosacral cord to influence urinary frequency.…”

Section: Discussionmentioning

confidence: 96%

Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia

et al. 2003

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Aim : To clarify the influence of hypertension on lower urinary tract symptoms (LUTS) we examined the relationship between blood pressure, LUTS, and the effect of terazosin on LUTS in patients with benign prostatic hyperplasia (BPH). Methods : The subjects were patients who had LUTS and BPH. They were treated with terazosin (1 mg, twice-a-day) for 12 weeks. Calculation of the International Prostate Symptom Score (IPSS), measurement of blood pressure, and uroflowmetry were performed before and after 12 weeks of therapy. Patients were divided into a normotensive (NT) group and a hypertensive (HT) group at the time of first examination. Results : The IPSS for urinary frequency and nocturia in BPH-HT patients ( n = 21; mean age, 71 years) were significantly higher than those in the BPH-NT patients ( n = 21; mean age, 69 years) before the administration of terazosin. The total IPSS the BPH-HT patients was also significantly higher than that of the BPH-NT patients. There were no differences of uroflowmetric parameters between the two groups. After 12 weeks of therapy, systolic and diastolic blood pressure decreased in the BPH-HT patients, but not in the BPH-NT patients. However, the systolic pressure of the BPH-HT patients was still significantly higher than that of the BPH-NT patients. The score for each IPSS parameter decreased in both groups, but the difference of the score between the two groups increased. Conclusion : Hypertension may worsen LUTS and may decrease the improvement of symptoms by terazosin.

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Section: Discussionmentioning

confidence: 96%

Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia

et al. 2003

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“…Naturally, differences in efficacy attributable to pharmacological differences in affinity for adrenoceptor subtypes have been the subject of numerous investigations. 6,7 Because Naf is available only in Japan, studies comparing Naf and Tam have similarly been performed only in Japan and have included those of Ohoka et al 8 Torimoto et al 9 Nishino et al 10 and Hayashi et al 11 Most of these studies have found that Tam decreases voiding symptoms and that Naf decreases storage symptoms (particularly nocturia). However, only Ohoka et al 8 and Hayashi et al 11 have provided such information as inclusion criteria and actual values of clinical variables.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of tamsulosin hydrochloride and naftopidil in patients with urinary disturbances caused by benign prostatic hyperplasia: A comparative, randomized, two‐drug crossover study

et al. 2003

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Background : The aim of the study presented here was to stratify drug therapy for patients with benign prostatic hyperplasia (BPH) displaying various voiding symptoms. Methods : Two different a 1-adrenoceptor antagonists; tamsulosin hydrochloride (Tam) and naftopidil (Naf ), were administered to 96 patients with BPH for 8 weeks in a crossover study.Results : With the administration of both drugs, the International Prostate Symptom Score (I-PSS) significantly decreased and the maximum urinary flow significantly increased. Whereas Naf monotherapy decreased the I-PSS for storage symptoms, Tam monotherapy decreased the I-PSS for voiding symptoms. In both the Naf-to-Tam and Tam-to-Naf groups, crossover was effective when the initial drug was judged subjectively and objectively to have been ineffective. Compliance was acceptable with both drugs. Conclusion : Our results show that either Naf or Tam can be used to treat patients on the basis of objective and subjective assessment of voiding symptoms. Our findings should be helpful for patient guidance and treatment of BPH.

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“…It is also possible that an increase of plasma catecholamine levels is not only related to nocturnal polyuria but also to diminished nocturnal bladder capacity. Intrathecal injection of an adrenergic alpha-1 receptor antagonist inhibits isovolumetric bladder contraction without affecting the bladder contraction pressure in rats (20). This result suggests that an increase of plasma catecholamine levels may influence the ascending limb of the micturition reflex in the spinal cord and induce the urge to urinate at smaller bladder volumes, a phenomenon similar to the urinary urge associated with stress.…”

Section: Discussionmentioning

confidence: 84%

Effects of walking exercise on nocturia in the elderly

et al. 2007

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We investigated whether nocturia in the elderly was improved by walking exercise, which involved walking rapidly for 30 min or more in the evening or night for 8 weeks. A questionnaire related to micturition and exercise, blood pressure, body composition analysis, blood biochemistry tests, and urinalysis were performed before and after 8 weeks of exercise to investigate the effects of walking. Thirty men (71 years old on average) continued the walking exercise for long enough to undergo evaluation. The number of episodes of nocturia decreased significantly (p < 0.001) from 3.3 ± 0.7 to 1.9 ± 0.8 after 8 weeks of walking exercise. The daytime urinary frequency, blood pressure, body weight, body fat ratio, edema ratio, serum catecholamines, triglycerides, and total cholesterol were also decreased. After 8 weeks of exercise, 20 of the subjects (67%) stated that sleep was deeper than before exercise. Assessment of the overall improvement showed that excellent or good results were obtained in 18 patients (60%). The main factor related to the influence of walking exercise on nocturia was that sleep became deeper, which increased the arousal threshold bladder volume. Walking exercise may also have a preventive effect on lifestyle-related diseases.

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Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats

Cited by 94 publications

References 9 publications

Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia

Influence of hypertension on lower urinary tract symptoms in benign prostatic hyperplasia

Usefulness of tamsulosin hydrochloride and naftopidil in patients with urinary disturbances caused by benign prostatic hyperplasia: A comparative, randomized, two‐drug crossover study

Effects of walking exercise on nocturia in the elderly

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