Effects of Intrathecal Tuberculin and Streptomycin in Tuberculous Meningitis

Smith, Harriet J; Vollum, R. L.

doi:10.1016/s0140-6736(50)91232-3

Cited by 78 publications

(10 citation statements)

References 11 publications

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“…tuberculin reaction. 8,9 We previously described serial CSF changes in a group of 99 children on standard oral anti-tuberculosis therapy and found a rise in CSF protein concentrations during the 2nd week of therapy, identical to the changes described in the non-steroid group in the present study. 10 A possible explanation for this rise in CSF protein level during the early stages of TBM treatment was offered by Cho et al who found evidence of increased central nervous system synthesis of immunoglobulin G and of increased permeability of the blood/brain barrier in patients with TBM.…”

Section: Discussionsupporting

confidence: 87%

The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis

Schoeman

Elshof

Laubscher

et al. 2001

Annals of Tropical Paediatrics

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Three recent studies found that corticosteroids improve clinical outcome and mortality in tuberculous meningitis (TBM), although the exact mechanism of action of the drug remains speculative. A number of reports on the effect of corticosteroids on cerebrospinal fluid (CSF) findings in TBM have been published, often with conflicting results regarding serial cell counts and protein levels. As part of a controlled, randomized trial on the effect of oral prednisone on outcome in childhood TBM at our institution, CSF was collected and analysed weekly during the 1st month of treatment. We found no significant difference in serial CSF cell counts between the steroid and non-steroid groups in the study. However, the steroid group had significantly lower CSF protein and globulin levels after the 1st month of treatment, and a more steady rise in CSF glucose levels than the non-steroid group. Knowledge of the different CSF responses during the course of anti-tuberculosis therapy is important in clinical decision-making.

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Section: Discussionsupporting

confidence: 87%

The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis

Schoeman

Elshof

Laubscher

et al. 2001

Annals of Tropical Paediatrics

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“…Their median length was two pages (interquartile range 2-4). Only 21 articles (6%) exceeded six pages and, apart from the Collings report, the longest was 12 pages 14. Collings's article was 30 pages.…”

Section: Origins and Publication Of The Reportmentioning

confidence: 96%

Collings report on general practice in England in 1950: unrecognised, pioneering piece of British social research?

Petchey

1995

BMJ

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Collings's grim description of postwar general practice in England and his sombre analysis of its prospects created an immediate sensation. In addition to its value as a historical document, the report is also regarded as a turning point in the postwar history of British general practice. The study is also interesting for another reason, which has not been acknowledged: Collings merits recognition as a pioneer ofethnographic research at a time when it was largely unknown elsewhere in British social research.

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“…It was an epoch-making paper and, many years afterwards, the then President, Dr Norman Tattersall, who was in the chair at the Oxford meeting considered it to be “the most exciting moment in his professional life” 1. In September 1946 Dr Honor Smith described the successful use of streptomycin for the treatment of tuberculous meningitis in a patient and this was probably the first scientific description of its clinical use in Britain 8 – 10…”

mentioning

confidence: 99%

The future of lung research in the UK

Holgate

2007

Thorax

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Effects of Intrathecal Tuberculin and Streptomycin in Tuberculous Meningitis

Cited by 78 publications

References 11 publications

The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis

The effect of adjuvant steroid treatment on serial cerebrospinal fluid changes in tuberculous meningitis

Collings report on general practice in England in 1950: unrecognised, pioneering piece of British social research?

The future of lung research in the UK

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