Effects of Intravascular Photobiomodulation on Insomnia, Muscle Soreness, and Biochemistry Profiles: An Eight-Year Retrospective Cohort

Abstract

Background: Although cognitive-behavioral therapy is the first-line treatment for insomnia, pharmacotherapy is often prescribed to treat insomnia and related symptoms. In addition, muscle relaxants are commonly prescribed to alleviate muscle soreness when the pain is unbearable. However, pharmacotherapy can lead to numerous side effects. The non-drug strategy intravascular laser irradiation of blood (iPBM) has been advocated to improve pain, wound healing, blood circulation, and blood cell function to relieve insomnia and muscle soreness symptoms. Therefore, we assessed whether iPBM improves blood parameters and compared drug use before and after iPBM therapy. Methods: Consecutive patients who received iPBM therapy between January 2013 and August 2021 were reviewed. The associations between laboratory data, pharmacotherapies, and iPBM therapy were retrospectively analyzed. We compared patient characteristics, blood parameters, and drug use within the three months before the first treatment and the three months after the last treatment. We also compared the changes before and after treatment in patients who received ≥10 or 1–9 iPBM treatments. Result: We assessed 183 eligible patients who received iPBM treatment. Of them, 18 patients reported insomnia disturbance, and 128 patients reported pain in any part of their body. After the treatment, HGB and HCT significantly increased after treatment in both the ≥10 and 1–9 iPBM treatment groups (HGB p < 0.001 and p = 0.046; HCT p < 0.001 and p = 0.029, respectively). Pharmacotherapy analysis revealed no significant differences in drug use before and after treatment, though drug use tended to decrease after iPBM. Conclusions: iPBM therapy is an efficient, beneficial, and feasible treatment that increases HGB and HCT. While the results of this study do not support the suggestion that iPBM reduces drug use, further larger studies using symptom scales are needed to confirm the changes in insomnia and muscle soreness after iPBM treatment.

Intravascular laser irradiation of blood as novel migraine treatment: an observational study

“…Despite these benefits, ILIB has not been used to treat migraine. Our previous case report showed that ILIB could improve perfusion of the contralateral cerebellum during diaschisis after an ischemic stroke event [ 17 ], or traumatic brain injury [ 14 ], and improve sleep quality in patients with musculoskeletal pain [ 18 , 19 ]. In the current study, we demonstrated ILIB-associated improvements in pain, cognition, disability, insomnia, and rCBF in patients with migraine.…”

Multi-resonator Wireless Inductive Power Link for Wearables on the 2D Surface and Implants in 3D Space of the Human Body

“…Multi-Resonator Wireless Inductive Power Link for Wearables on the 2D Surface and Implants in 3D Space of the Human Body T Intravascular Photo-biomodulation (iPBM), or Intravascular Laser Irradiation of Blood Therapy (ILIB, using laser light through optical fibers inserted into veins). These are all proven low/non-invasive treatment methods with potential benefits such as wound healing, pain relief, anti-inflammatory responses, anti-edema effects, nerve regrowth, tissue repair, and regeneration [31]- [33]. They enhance blood circulation and optimize blood cell functionality, ensuring beneficial effects in reducing inflammation, enhancing antioxidants, and improving hemodynamic parameters.…”